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  • Azzouz M., Hottinger A., Paterna J. C., Zurn A. D., Aebischer P. and Bueler H. (2000) Increased motoneuron survival and improved neuromuscular function in transgenic ALS mice after intraspinal injection of an adeno-associated virus encoding bcl-2. Hum. Mol. Genet. 9, 803811.
  • Azzouz M., Ralph G. S., Storkebaum E., Walmsley L. E., Mitrophanous K. A., Kingsman S. M., Carmeliet P. and Mazarakis N. D. (2004) VEGF delivery with retrogradely transported lentivector prolongs survival in a mouse ALS model. Nature 429, 413417.
  • Bartholdi D., Rubin B. P. and Schwab M. E. (1997) VEGF mRNA induction correlates with changes in the vascular architecture upon spinal cord damage in the rat. Eur. J. Neurosci. 9, 25492560.
  • Beierle E. A., Strande L. F. and Chen M. K. (2002) VEGF upregulates BCL-2 expression and is associated with decreased apoptosis in neuroblastoma cells. J. Pediatr. Surg. 37, 467471.
  • Beierle E. A., Nagaram A., Dai W., Iyengar M. and Chen M. K. (2005) VEGF-mediated survivin expression in neuroblastoma cells. J. Surg. Res. 127, 2128.
  • Boillee S., Vande Velde C. and Cleveland D. W. (2006a) ALS: a disease of motor neurons and their nonneuronal neighbors. Neuron 52, 3959.
  • Boillee S., Yamanaka K., Lobsiger C. S., Copeland N. G., Jenkins N. A., Kassiotis G., Kollias G. and Cleveland D. W. (2006b) Onset and progression in inherited ALS determined by motor neurons and microglia. Science 312, 13891392.
  • Brockington A., Wharton S. B., Fernando M., Gelsthorpe C. H., Baxter L., Ince P. G., Lewis C. E. and Shaw P. J. (2006) Expression of vascular endothelial growth factor and its receptors in the central nervous system in amyotrophic lateral sclerosis. J. Neuropathol. Exp. Neurol. 65, 2636.
  • Choi D. W. (1994) Glutamate receptors and the induction of excitotoxic neuronal death. Prog. Brain Res. 100, 4751.
  • Clement A. M., Nguyen M. D., Roberts E. A. et al. (2003) Wild-type nonneuronal cells extend survival of SOD1 mutant motor neurons in ALS mice. Science 302, 113117.
  • Deveraux Q. L. and Reed T. C. (1999) IAP family proteins – suppressors of apoptosis. Gene Dev. 13, 239252.
  • Dewil M., Lambrechts D., Sciot R., Shaw P. J., Ince P. G., Robberecht W. and Van Den Bosch L. (2007) Vascular endothelial growth factor counteracts the loss of phospho-Akt preceding motor neurone degeneration in amyotrophic lateral sclerosis. Neuropathol. Appl. Neurobiol. 33, 499509.
  • Dolcet X., Egea J., Soler R. M., Martin-Zanca D. and Comella J. X. (1999) Activation of phosphatidylinositol 3-kinase, but not extracellular-regulated kinases is necessary to mediate brain-derived neurotrophic factor-induced motoneuron survival. J. Neurochem. 73, 521531.
  • Fu C. Y., Hong G. X. and Wang F. B. (2005) Expression of vascular endothelial growth factor and its fetal liver kinase-1 receptor in spinal cord and dorsal root ganglia after neurotomy of sciatic nerve in rats. Chin. J. Traumatol. 8(1), 1722.
  • Gupta K., Kshirsagar S., Li W., Gui L. Z., Ramakrishnan S., Gupta P., Law P. Y. and Hebbel R. P. (1999) VEGF prevents apoptosis of human microvascular endothelial cells via opposing effects on MAP/ERK and SAPK/JNK signaling. Exp. Cell Res. 247, 495504.
  • Howard S., Bottino C., Brooke S., Cheng E., Giffard R. G. and Sapolsky R. (2002) Neuroprotective effects of bcl-2 overexpression in hippocampal cultures: interactions with pathways of oxidative damage. J. Neurochem. 83, 914923.
  • Ijichi A., Sakuma S. and Tofilon P. J. (1995) Hypoxia-induced vascular endothelial growth factor expression in normal rat astrocyte cultures. Glia 14, 8793.
  • Islamov R. R., Chintalgattu V., Pak E. S., Katwa L. C. and Murashov A. K. (2004) Induction of VEGF and its Flt-1 receptor after sciatic nerve crush injury. Neuroreport 15, 21172121.
  • Jiang Y. Y., De Bruin A., Caldas H., Fangusaro J., Hayes J., Conway E. M., Robinson M. L. and Altura R. A. (2005) Essential role for survivin in early brain development. J. Neurosci. 25, 69626970.
  • Jin K. L., Mao X. O. and Greenberg D. A. (2000a) Vascular endothelial growth factor: direct neuroprotective effect in in vitro ischemia. Proc. Natl Acad. Sci. USA 97, 1024210247.
  • Jin K. L., Mao X. O. and Greenberg D. A. (2000b) Vascular endothelial growth factor rescues HN33 neural cells from death induced by serum withdrawal. J. Mol. Neurosci. 14, 197203.
  • Johnson E. A., Svetlov S. I., Pike B. R., Tolentino P. J., Shaw G., Wang K. K. W., Hayes R. L. and Pineda J. A. (2004) Cell-specific upregulation of survivin after experimental traumatic brain injury in rats. J. Neurotrauma 21, 11831195.
  • Kilic E., Kilic U., Wang Y. M., Bassetti C. L., Marti H. H. and Hermann D. M. (2006) The phosphatidylinositol-3 kinase/Akt pathway mediates VEGF’s neuroprotective activity and induces blood brain barrier permeability after focal cerebral ischemia. FASEB J. 20, 11851196.
  • Lambrechts D. and Carmeliet P. (2006) VEGF at the neurovascular interface: therapeutic implications for motor neuron disease. Biochim. Biophys. Acta 1762, 11091121.
  • Lambrechts D., Storkebaum E., Morimoto M. et al. (2003) VEGF is a modifier of amyotrophic lateral sclerosis in mice and humans and protects motoneurons against ischemic death. Nat. Genet. 34, 383394.
  • Lawrence M. S., Ho D. Y., Sun G. H., Steinberg G. K. and Sapolsky R. M. (1996) Overexpression of bcl-2 with herpes simplex virus vectors protects CNS neurons against neurological insults in vitro and in vivo. J. Neurosci. 16, 486496.
  • Li B. L., Xu W., Luo C., Gozal D. and Liu R. G. (2003) VEGF-induced activation of the PI3-K/Akt pathway reduces mutant SOD1-mediated motor neuron cell death. Mol. Brain Res. 111, 155164.
  • Llado J., Haenggeli C., Maragakis N. J., Snyder E. Y. and Rothstein J. D. (2004) Neural stem cells protect against glutamate-induced excitotoxicity and promote survival of injured motor neurons through the secretion of neurotrophic factors. Mol. Cell. Neurosci. 27, 322331.
  • Matsuzaki H., Tamatani M., Yamaguchi A., Namikawa K., Kiyama H., Vitek M. P., Mitsuda N. and Tohyama M. (2001) Vascular endothelial growth factor rescues hippocampal neurons from glutamate-induced toxicity: signal transduction cascades. FASEB J. 15, 12181220.
  • Mesri M., Morales-Ruiz M., Ackermann E. J., Bennett C. F., Pober J. S., Sessa W. C. and Altieri D. C. (2001) Suppression of vascular endothelial growth factor-mediated endothelial cell protection by survivin targeting. Am. J. Pathol. 158, 17571765.
  • Meyer M., Clauss M., Lepple-Wienhues A., Waltenberger J., Augustin H. G., Ziche M., Lanz C., Buttner M., Rziha H. J. and Dehio C. (1999) A novel vascular endothelial growth factor encoded by Orf virus, VEGF-E mediates angiogenesis via signalling through VEGFR-2 (KDR) but not VEGFR-1 (Flt-1) receptor tyrosine kinases. EMBO J. 18, 363374.
  • Namikawa K., Honma M., Abe K., Takeda M., Mansur K., Obata T., Miwa A., Okado H. and Kiyama H. (2000) Akt/protein kinase B prevents injury-induced motoneuron death and accelerates axonal regeneration. J. Neurosci. 20, 28752886.
  • Newbern J., Taylor A., Robinson M., Li L. and Milligan C. E. (2005) Decreases in phosphoinositide-3-kinase/Akt and extracellular signal-regulated kinase 1/2 signaling activate components of spinal motoneuron death. J. Neurochem. 94, 16521665.
  • Ogunshola O. O., Antic A., Donoghue M. J., Fan S. Y., Kim H., Stewart W. B., Madri J. A. and Ment L. R. (2002) Paracrine and autocrine functions of neuronal vascular endothelial growth factor (VEGF) in the central nervous system. J. Biol. Chem. 277, 1141011415.
  • Oosthuyse B., Moons L., Storkebaum E. et al. (2001) Deletion of the hypoxia-response element in the vascular endothelial growth factor promoter causes motor neuron degeneration. Nat. Genet. 28, 131138.
  • Pugazhenthi S., Nesterova A., Sable C., Heidenreich K. A., Boxer L. M., Heasley L. E. and Reusch J. E. B. (2000) Akt/protein kinase B up-regulates Bcl-2 expression through cAMP-response element-binding protein. J. Biol. Chem. 275, 1076110766.
  • Rosenstein J. M., Mani N., Khaibullina A. and Krum J. M. (2003) Neurotrophic effects of vascular endothelial growth factor on organotypic cortical explants and primary cortical neurons. J. Neurosci. 23, 1103611044.
  • Rothstein J. D., Jin L., Dykeshoberg M. and Kuncl R. W. (1993) Chronic inhibition of glutamate uptake produces a model of slow neurotoxicity. Proc. Natl Acad. Sci. USA 90, 65916595.
  • Rothstein J. D., Vankammen M., Levey A. I., Martin L. J. and Kuncl R. W. (1995) Selective loss of glial glutamate transporter (Glt-1) in amyotrophic lateral sclerosis. Ann. Neurol. 38, 7384.
  • Shiote M., Nagano I., Ilieva H., Murakami T., Narai H., Ohta Y., Nagata T., Shoji M. and Abe K. (2005) Reduction of a vascular endothelial growth factor receptor, fetal liver kinase-1 by antisense oligonucleotides induces motor neuron death in rat spinal cord exposed to hypoxia. Neuroscience 132, 175182.
  • Silverman W. F., Krum J. M., Mani N. and Rosenstein J. M. (1999) Vascular, glial and neuronal effects of vascular endothelial growth factor in mesencephalic explant cultures. Neuroscience 90, 15291541.
  • Skold M., Cullheim S., Hammarberg H., Piehl F., Suneson A., Lake S., Sjogren A., Walum E. and Risling M. (2000) Induction of VEGF and VEGF receptors in the spinal cord after mechanical spinal injury and prostaglandin administration. Eur. J. Neurosci. 12, 36753686.
  • Soler R. M., Dolcet X., Encinas M., Egea J., Bayascas J. R. and Comella J. X. (1999) Receptors of the glial cell line-derived neurotrophic factor family of neurotrophic factors signal cell survival through the phosphatidylinositol 3-kinase pathway in spinal cord motoneurons. J. Neurosci. 19, 91609169.
  • Sondell M., Sundler F. and Kanje M. (2000) Vascular endothelial growth factor is a neurotrophic factor which stimulates axonal outgrowth through the flk-1 receptor. Eur. J. Neurosci. 12, 42434254.
  • Storkebaum E., Lambrechts D. and Carmeliet P. (2004) VEGF: once regarded as a specific angiogenic factor, now implicated in neuroprotection. Bioessays 26, 943954.
  • Storkebaum E., Lambrechts D., Dewerchin M. et al. (2005) Treatment of motoneuron degeneration by intracerebroventricular delivery of VEGF in a rat model of ALS. Nat. Neurosci. 8, 8592.
  • Svensson B., Peters M., Konig H. G., Poppe M., Levkau B., Rothermundt M., Arolt T., Kogel D. and Prehn J. H. M. (2002) Vascular endothelial growth factor protects cultured rat hippocampal neurons against hypoxic injury via an antiexcitotoxic, caspase-independent mechanism. J. Cereb. Blood Flow Metab. 22, 11701175.
  • Tovar Y. R., Zepeda A. and Tapia R. (2007) Vascular endothelial growth factor induces protection against excitotoxicity in spinal motoneurons in vivo. J. Neurochem. 102, 228.
  • Tsao M. N., Li Y. Q., Lu G., Xu Y. and Wong C. S. (1999) Upregulation of vascular endothelial growth factor is associated with radiation-induced blood-spinal cord barrier breakdown. J. Neuropathol. Exp. Neurol. 58, 10511060.
  • Van Den Bosch L., Storkebaum E., Vleminckx V., Moons L., Vanopdenbosch L., Scheveneels W., Carmeliet P. and Robberecht W. (2004) Effects of vascular endothelial growth factor (VEGF) on motor neuron degeneration. Neurobiol. Dis. 17, 2128.
  • Wang Y., Mao X. O., Xie L., Banwait S., Marti S. S., Greenberg D. A. and Jin K. (2007) Vascular endothelial growth factor overexpression delays neurodegeneration and prolongs survival in amyotrophic lateral sclerosis mice. J. Neurosci. 27, 304307.
  • Zhong L. T., Kane D. J. and Bredesen D. E. (1993) Bcl-2 blocks glutamate toxicity in neural cell lines. Mol. Brain Res. 19, 353355.