BMP inhibition enhances axonal growth and functional recovery after spinal cord injury
Article first published online: 24 JAN 2008
© 2008 The Authors. Journal Compilation © 2008 International Society for Neurochemistry
Journal of Neurochemistry
Volume 105, Issue 4, pages 1471–1479, May 2008
How to Cite
Matsuura, I., Taniguchi, J., Hata, K., Saeki, N. and Yamashita, T. (2008), BMP inhibition enhances axonal growth and functional recovery after spinal cord injury. Journal of Neurochemistry, 105: 1471–1479. doi: 10.1111/j.1471-4159.2008.05251.x
- Issue published online: 24 JAN 2008
- Article first published online: 24 JAN 2008
- Received August 23, 2007; revised manuscript received December 15, 2007; accepted January 16, 2008.
- bone morphogenetic proteins;
- spinal cord
Bone morphogenetic proteins (BMPs) are multifunctional growth factors that belong to the transforming growth factor-β superfamily. BMPs regulate several crucial aspects of embryonic development and organogenesis. The reemergence of BMPs in the injured adult CNS suggests their involvement in the pathogenesis of the lesion. Here, we demonstrate that BMPs are potent inhibitors of axonal regeneration in the adult spinal cord. The expression of BMP-2/4 is elevated in oligodendrocytes and astrocytes around the injury site following spinal cord contusion. Intrathecal administration of noggin – a soluble BMP antagonist—leads to enhanced locomotor activity and reveals significant regrowth of the corticospinal tract after spinal cord contusion. Thus, BMPs play a role in inhibiting axonal regeneration and limiting functional recovery following injury to the CNS.