- Top of page
- AD amyloid neuropathology as a target for therapeutic dietary lifestyle factors
- Aβ neuropathology and mitochondrial energy metabolism in AD pathogenesis
- Metabolic syndrome as a risk factor for AD: the role of obesity
- The role of diabetogenic dietary lifestyles and altered IR signaling in AD: experimental approaches and therapeutic implications
- Calorie restriction as a potential preventative dietary lifestyle factor in AD
- Sirtuins at the crossroads of the promotion of longevity and the prevention of AD amyloid neuropathology following calorie restriction
- Dietary phytonutrients and food supplements: a role in the prevention of AD dementia?
- The potential beneficial role of fruit polyphenols in AD
- The benefits of moderate consumption of red wine in the prevention of AD
- The role of dietary homocysteine in AD
- Dietary lifestyles: recommendations for the prevention of metabolic syndrome and AD dementia
Since Alzheimer’s disease (AD) has no cure or preventive treatment, an urgent need exists to find a means of preventing, delaying the onset, or reversing the course of the disease. Clinical and epidemiological evidence suggests that lifestyle factors, especially nutrition, may be crucial in controlling AD. Unhealthy lifestyle choices lead to an increasing incidence of obesity, dyslipidemia and hypertension – components of the metabolic syndrome. These disorders can also be linked to AD. Recent research supports the hypothesis that calorie intake, among other non-genetic factors, can influence the risk of clinical dementia. In animal studies, high calorie intake in the form of saturated fat promoted AD-type amyloidosis, while calorie restriction via reduced carbohydrate intake prevented it. Pending further study, it is prudent to recommend to those at risk for AD – e.g. with a family history or features of metabolic syndrome, such as obesity, insulin insensitivity, etc. – to avoid foods and beverages with added sugars; to eat whole, unrefined foods with natural fats, especially fish, nuts and seeds, olives and olive oil; and to minimize foods that disrupt insulin and blood sugar balance.