SEARCH

SEARCH BY CITATION

References

  • Hardy J. and Selkoe D. J. (2002) The amyloid hypothesis of Alzheimer’s disease: progress and problems on the road to therapeutics. Science 297, 353356.
  • Hilbich C., Monning U., Grund C., Masters C. L. and Beyreuther K. (1993) Amyloid-like properties of peptides flanking the epitope of amyloid precursor protein-specific monoclonal antibody 22C11. J. Biol. Chem. 268, 2657126577.
  • Kim K. S., Wen G. Y., Bancher C., Chen C. M. J., Sapienza V. J., Hong H. and Wisniewski H. M. (1990) Detection and quantitation of amyloid B-peptide with 2 monoclonal antibodies. Neurosci. Res. Commun. 7, 113122.
  • Lichtenthaler S. F., Wang R., Grimm H., Uljon S. N., Masters C. L. and Beyreuther K. (1999) Mechanism of the cleavage specificity of Alzheimer’s disease gamma-secretase identified by phenylalanine-scanning mutagenesis of the transmembrane domain of the amyloid precursor protein. Proc. Natl Acad. Sci. USA 96, 30533058.
  • Pinnix I., Musunuru U., Tun H., Sridharan A., Golde T., Eckman C., Ziani-Cherif C., Onstead L. and Sambamurti K. (2001) A novel gamma-secretase assay based on detection of the putative C-terminal fragment-gamma of amyloid beta protein precursor. J. Biol. Chem. 276, 481487.
  • Qi-Takahara Y., Morishima-Kawashima M., Tanimura Y. et al. (2005) Longer forms of amyloid beta protein: implications for the mechanism of intramembrane cleavage by gamma-secretase. J. Neurosci. 25, 436445.
  • Sastre M., Steiner H., Fuchs K., Capell A., Multhaup G., Condron M. M., Teplow D. B. and Haass C. (2001) Presenilin-dependent gamma-secretase processing of beta-amyloid precursor protein at a site corresponding to the S3 cleavage of Notch. EMBO Rep. 2, 835841.
  • Schechter I. and Berger A. (1967) On the size of the active site in proteases. I. Papain. Biochem. Biophys. Res. Commun. 27, 157162.
  • Schroeter E. H., Ilagan M. X., Brunkan A. L. et al. (2003) A presenilin dimer at the core of the gamma-secretase enzyme: insights from parallel analysis of Notch 1 and APP proteolysis. Proc. Natl Acad. Sci. USA 100, 1307513080.
  • Thinakaran G., Teplow D. B., Siman R., Greenberg B. and Sisodia S. S. (1996) Metabolism of the “Swedish” amyloid precursor protein variant in neuro2a (N2a) cells. Evidence that cleavage at the “beta-secretase” site occurs in the Golgi apparatus. J. Biol. Chem. 271, 93909397.
  • Wang R., Sweeney D., Gandy S. E. and Sisodia S. S. (1996) The profile of soluble amyloid beta protein in cultured cell media. Detection and quantification of amyloid beta protein and variants by immunoprecipitation-mass spectrometry. J. Biol. Chem. 271, 3189431902.
  • Weidemann A., Konig G., Bunke D., Fischer P., Salbaum J. M., Masters C. L. and Beyreuther K. (1989) Identification, biogenesis, and localization of precursors of Alzheimer’s disease A4 amyloid protein. Cell 57, 115126.
  • Wolfe M. S., Xia W., Moore C. L., Leatherwood D. D., Ostaszewski B., Rahmati T., Donkor I. O. and Selkoe D. J. (1999) Peptidomimetic probes and molecular modeling suggest that Alzheimer’s gamma-secretase is an intramembrane-cleaving aspartyl protease. Biochemistry (Mosc.) 38, 47204727.
  • Xu X., Shi Y. C., Gao W., Mao G., Zhao G., Agrawal S., Chisolm G. M., Sui D. and Cui M. Z. (2002) The novel presenilin-1-associated protein is a proapoptotic mitochondrial protein. J. Biol. Chem. 277, 4891348922.
  • Zhao G., Mao G., Tan J., Dong Y., Cui M.-Z., Kim S.-H. and Xu X. (2004) Identification of a new presenilin-dependent ζ-cleavage site within the transmembrane domain of amyloid precursor protein. J. Biol. Chem. 279, 5064750650.
  • Zhao G., Cui M. Z., Mao G., Dong Y., Tan J., Sun L. and Xu X. (2005) γ-Cleavage is dependent on ζ-cleavage during the proteolytic processing of amyloid precursor protein within its transmembrane domain. J. Biol. Chem. 280, 3768937697.
  • Zhao G., Tan J., Mao G., Cui M. Z. and Xu X. (2007) The same gamma-secretase accounts for the multiple intramembrane cleavages of APP. J. Neurochem. 100, 12341246.