Muscarinic toxins: tools for the study of the pharmacological and functional properties of muscarinic receptors
Version of Record online: 23 APR 2009
© 2009 The Authors. Journal Compilation © 2009 International Society for Neurochemistry
Journal of Neurochemistry
Volume 109, Issue 5, pages 1193–1202, June 2009
How to Cite
Servent, D. and Fruchart-Gaillard, C. (2009), Muscarinic toxins: tools for the study of the pharmacological and functional properties of muscarinic receptors. Journal of Neurochemistry, 109: 1193–1202. doi: 10.1111/j.1471-4159.2009.06092.x
- Issue online: 12 MAY 2009
- Version of Record online: 23 APR 2009
- Received January 28, 2009; revised manuscript received March 4, 2009; accepted April 1, 2009.
- cholinergic function;
- mamba venom;
- muscarinic acetylcholine receptor;
- muscarinic toxins;
- snake neurotoxins.
Muscarinic receptors mediate metabotropic actions of acetylcholine in the CNS and PNS and autocrine functions of acetylcholine in non-neuronal systems. Because of the lack of highly selective muscarinic ligands, the precise location, functional role, and roles in various diseases of the five muscarinic receptor subtypes remain unclear. Muscarinic toxins isolated from the venom of Dendroaspis snakes have a natural high affinity and selectivity, associated with roles as competitive antagonists, allosteric modulators, and potential agonists. These toxins may therefore be invaluable tools for studying muscarinic receptors. We review data on the structural and pharmacological characterization of the muscarinic toxins, focusing on recent structure–function studies on toxin–receptor interactions. We discuss the potential benefits of using these toxins for investigating muscarinic function in vivo.