The amyloid hypothesis for Alzheimer’s disease: a critical reappraisal
Article first published online: 18 MAY 2009
© 2009 The Author. Journal Compilation © 2009 International Society for Neurochemistry
Journal of Neurochemistry
Volume 110, Issue 4, pages 1129–1134, August 2009
How to Cite
Hardy, J. (2009), The amyloid hypothesis for Alzheimer’s disease: a critical reappraisal. Journal of Neurochemistry, 110: 1129–1134. doi: 10.1111/j.1471-4159.2009.06181.x
- Issue published online: 21 JUL 2009
- Article first published online: 18 MAY 2009
- Received March 12, 2009; revised manuscript received May 4, 2009; accepted May 7, 2009.
- Alzheimer’s disease;
- congophilic angiopathy;
The amyloid hypothesis has been the basis for most work on the pathogenesis of Alzheimer’s disease. Recent clinical trials based on this hypothesis have been inconclusive. In this article I review the current status of the hypothesis and suggest that a major scientific need is to understand the normal function of amyloid-β precursor protein (APP) and think how this may relate to the cell death in the disease process.