- Top of page
- Predictions of the amyloid hypothesis: have they been met?
- What have the ‘amyloid’ clinical trials taught us so far?
- Are there alternatives to the amyloid hypothesis which account for the genetic data?
- How should we move forward?
The amyloid hypothesis has been the basis for most work on the pathogenesis of Alzheimer’s disease. Recent clinical trials based on this hypothesis have been inconclusive. In this article I review the current status of the hypothesis and suggest that a major scientific need is to understand the normal function of amyloid-β precursor protein (APP) and think how this may relate to the cell death in the disease process.