1471-4159/asset/olbannerleft.gif?v=1&s=4636ca86ad7e40d133e71d09a5d759010472e0c2)
1471-4159/asset/olbannerright.gif?v=1&s=38094197c2d87aeb3b86aa293b5858c5c15cca29)
You have full text access to this OnlineOpen article
Relationship between microglial activation and dopaminergic neuronal loss in the substantia nigra: a time course study in a 6-hydroxydopamine model of Parkinson’s disease
Article first published online: 22 JUN 2009
DOI: 10.1111/j.1471-4159.2009.06189.x
© 2009 The Authors. Journal Compilation © 2009 International Society for Neurochemistry
Additional Information
How to Cite
Marinova-Mutafchieva, L., Sadeghian, M., Broom, L., Davis, J. B., Medhurst, A. D. and Dexter, D. T. (2009), Relationship between microglial activation and dopaminergic neuronal loss in the substantia nigra: a time course study in a 6-hydroxydopamine model of Parkinson’s disease. Journal of Neurochemistry, 110: 966–975. doi: 10.1111/j.1471-4159.2009.06189.x
Publication History
- Issue published online: 13 JUL 2009
- Article first published online: 22 JUN 2009
- Received May 12, 2009 accepted May 18, 2009.
References
- , , , , , and (1994) Early response of brain resident microglia to kainic acid-induced hippocampal lesions. Brain Res. 635, 257–268.
- , , and (1996) Phenotypic diversity and kinetics of proliferating microglia and astrocytes following cortical stab wounds. Glia 16, 368–382.
- , , and (1994) Phagocytic activity of macrophages and microglial cells during the course of acute and chronic relapsing experimental autoimmune encephalomyelitis. J. Neurosci. Res. 38, 365–375.
- , and (1991) Partial lesion of the substantia nigra: relation between extent of lesion and rotational behaviour. Brain Res. 553, 275–283.
- , , et al. (2003) Microglial phagocytosis of dopamine neurons at early phases of apoptosis. Cell. Mol. Neurobiol. 23, 551–560.
- , , , , , , and (2006) Pathological dynamics of activated microglia following medial forebrain bundle transection. Glia 53, 92–102.
- , , , and (2005) Microglial inflammation in the parkinsonian substantia nigra: relationship to alpha-synuclein deposition. J. Neuroinflammation 2, 14.
- , , , , and (1994) Rat macrophage lysosomal membrane antigen recognized by monoclonal antibody ED1. Immunology 83, 140–147.
- , and (2006) Effects of anaesthetics on the loss of nigrostriatal dopaminergic neurons by 6-hydroxydopamine in rats. J Neural Transm. 113, 583–91.
- (1996) Neuropathology of Parkinson’s disease. J. Neuropathol. Exp. Neurol. 55, 259–272.
- and (1996) Cellular reactions at the lesion site after crushing of the rat optic nerve. Glia 16, 227–240.
- , , , , and (2002) Microglial activation-mediated delayed and progressive degeneration of rat nigral dopaminergic neurons: relevance to Parkinson’s disease. J. Neurochem. 81, 1285–1297.
- , and (2006) Innate immunity triggers oligodendrocyte progenitor reactivity and confines damages to brain injuries. FASEB J. 20, 750–752.
- , and (1988) Axotomy of the rat facial nerve leads to increased CR3 complement receptor expression by activated microglial cells. J. Neurosci. Res. 21, 18–24.
- , , , and (1998) Activated microglial cells migrate towards sites of excitotoxic neuronal injury inside organotypic hippocampal slice cultures. Eur. J. Neurosci. 10, 3284–3290.
- , , , and (2005) Inflammatory process as a determinant factor for the degeneration of substantia nigra dopaminergic neurons. J. Neural Transm. 112, 111–119.
- , and (2002) Phosphatidylserine-dependent ingestion of apoptotic cells promotes TGF-beta1 secretion and the resolution of inflammation. J. Clin. Invest. 109, 41–50.
- , , , and (2002) Involvement of inducible nitric oxide synthase in inflammation-induced dopaminergic neurodegeneration. Neuroscience 110, 49–58.
- and (1992) Activation and re-expression of surface antigen in microglia following an epidural application of kainic acid in the rat brain. J. Anat. 180, 333–342.
- , , , , and (2000) Regional difference in susceptibility to lipopolysaccharide-induced neurotoxicity in the rat brain: role of microglia. J. Neurosci. 20, 6309–6316.
- , and (2000) Inflammatory regulators in Parkinson’s disease: iNOS, lipocortin-1, and cyclooxygenases-1 and -2. Mol. Cell. Neurosci. 16, 724–739.
- (1996) Microglia: a sensor for pathological events in the CNS. Trends Neurosci. 19, 312–318.
- , , , and (1999) MHC class II positive microglia and lymphocytic infiltration are present in the substantia nigra and striatum in mouse model of Parkinson’s disease. Acta Neurobiol. Exp. (Wars) 59, 1–8.
- , , , , and (1999) Evidence of active nerve cell degeneration in the substantia nigra of humans years after 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine exposure. Ann. Neurol. 46, 598–605.
- , and (2003) Parkinson’s disease and exposure to infectious agents and pesticides and the occurrence of brain injuries: role of neuroinflammation. Environ. Health Perspect. 111, 1065–1073.
- and (2004) Neurons and astrocytes respond to prion infection by inducing microglia recruitment. J. Neurosci. 24, 620–627.
- , and (1988) Expression of the histocompatibility glycoprotein HLA-DR in neurological disease. Acta Neuropathol. (Berl) 76, 550–557.
- , and (2005) Inflammation, the complement system and the diseases of aging. Neurobiol. Aging 26 (Suppl. 1), 94–97.
- , , and (2000) The absence of reactive astrocytosis is indicative of a unique inflammatory process in Parkinson’s disease. Neuroscience 95, 425–432.
- , , , , , and (1999) Estrogen and microglia: A regulatory system that affects the brain. J. Neurobiol. 40, 484–496.
- , , , , and (2006) Microglia provide neuroprotection after ischemia. FASEB J. 20, 714–716.
- and (1986) The Rat Brain in Stereotaxic Coordinates. Academic Press, San Diego.
- and (2002) Reciprocal interactions between microglia and neurons: from survival to neuropathology. Rev. Neurosci. 13, 221–242.
- , , , , , , and (2007) Systemic LPS causes chronic neuroinflammation and progressive neurodegeneration. Glia 55, 453–462.
- (2003) “Recruitment signals” from apoptotic cells: invitation to a quiet meal. Cell 113, 817–820.
- , and (1991) Persistence of fluoro-gold following degeneration of labeled motoneurons is due to phagocytosis by microglia and macrophages. Neuroscience 44, 765–776.
- , , , , , , and (2007) Bone-marrow-derived cell differentiation into microglia: a study in a progressive mouse model of Parkinson’s disease. Neurobiol. Dis. 28, 316–25.
- , , , , and (2007) Mechanism of 6-hydroxydopamine neurotoxicity: role of NADPH oxidase and microglial activation in 6-hydroxydopamine-induced degeneration of dopaminergic neurons. J. Neurochem. 103, 145–156.
- and (2000) Corpse clearance defines the meaning of cell death. Nature 407, 784–788.
- , , , and (1999) Microglial motility in the rat facial nucleus following peripheral axotomy. J. Neurocytol. 28, 439–453.
- , , and (2001) IL-16 is differentially expressed in the developing human fetal brain by microglial cells in zones of neuropoesis. Int. J. Dev. Neurosci. 19, 93–100.
- and (2006) Neuroprotective properties of the innate immune system and bone marrow stem cells in Alzheimer’s disease. Mol. Psychiatry 11, 327–335.
- , , , , and (2006) Deficiency of TNF receptors suppresses microglial activation and alters the susceptibility of brain regions to MPTP-induced neurotoxicity: role of TNF-alpha. FASEB J. 20, 670–682.
- , and (2001) Dynamics of microglial activation: a confocal time-lapse analysis in hippocampal slices. Glia 33, 256–266.
- and (1988) Response of endogenous glial cells to motor neuron degeneration induced by toxic ricin. J. Comp. Neurol. 268, 248–263.
- , , , , , , , and (2003) Age-related microglial activation in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced dopaminergic neurodegeneration in C57BL/6 mice. Brain Res. 964, 288–294.
- and (1997) In situ detection of apoptotic nuclei in the substantia nigra compacta of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-treated mice using terminal deoxynucleotidyl transferase labelling and acridine orange staining. Neuroscience 77, 1037–1048.
- , , , , and (2005) Neuroprotective effects of metabotropic glutamate receptor ligands in a 6-hydroxydopamine rodent model of Parkinson’s disease. Eur. J. Neurosci. 22, 1799–806.