You have free access to this content
Acrolein scavenging: a potential novel mechanism of attenuating oxidative stress following spinal cord injury
Article first published online: 23 SEP 2009
DOI: 10.1111/j.1471-4159.2009.06395.x
© 2009 The Authors. Journal Compilation © 2009 International Society for Neurochemistry
Additional Information
How to Cite
Hamann, K. and Shi, R. (2009), Acrolein scavenging: a potential novel mechanism of attenuating oxidative stress following spinal cord injury. Journal of Neurochemistry, 111: 1348–1356. doi: 10.1111/j.1471-4159.2009.06395.x
Publication History
- Issue published online: 20 NOV 2009
- Article first published online: 23 SEP 2009
- Received April 6, 2009; revised manuscript received July 28, 2009; accepted September 14, 2009.
References
- and (1993) Acrolein-induced oxygen radical formation. Free Radic. Biol. Med. 15, 187–193.
- and (2006) Pharmacological Approaches To Repair the Injured Spinal Cord. J. Neurotrauma 23, 318–334.
- (2002) Steroids for acute spinal cord injury. Cochrane Database Syst. Rev. CD001046.
- and (2002) Neurological and functional status 1 year after acute spinal cord injury: estimates of functional recovery in National Acute Spinal Cord Injury Study II from results modeled in National Acute Spinal Cord Injury Study III. J. Neurosurg. 96, 259–266.
- , , et al. (1997) Administration of methylprednisolone for 24 or 48 hours or tirilazad mesylate for 48 hours in the treatment of acute spinal cord injury. Results of the Third National Acute Spinal Cord Injury Randomized Controlled Trial. National Acute Spinal Cord Injury Study. JAMA 277, 1597–1604.
- , , et al. (1998) Methylprednisolone or tirilazad mesylate administration after acute spinal cord injury: 1-year follow up. Results of the Third National Acute Spinal Cord Injury randomized controlled trial. J. Neurosurg. 89, 699–706.
- and (1989) Central nervous system trauma and stroke I. Biochemical considerations for oxygen radical formation and lipid peroxidation. Free Radic. Biol. Med. 6, 289–301.
- (2008) Potentialities and pitfalls accompanying chemico-pharmacological strategies against endogenous electrophiles and carbonyl stress. Chem. Res. Toxicol. 21, 779–786.
- and (2006) Hydralazine inhibits rapid acrolein-induced protein oligomerization: role of aldehyde scavenging and adduct trapping in cross-link blocking and cytoprotection. Mol. Pharmacol. 69, 1056–1065.
- , and (2000) The antihypertensive hydralazine is an efficient scavenger of acrolein. Redox. Rep. 5, 47–49.
- , , , and (2002) Aldehyde-sequestering drugs: tools for studying protein damage by lipid peroxidation products. Toxicology 181–182, 229–236.
- , , , and (2004) Protein adduct-trapping by hydrazinophthalazine drugs: mechanisms of cytoprotection against acrolein-mediated toxicity. Mol. Pharmacol. 65, 655–664.
- , and (2009) Protein modification by acrolein: formation and stability of cysteine adducts. Chem. Res. Toxicol. 22, 708–716.
- , and (1999) Protein-bound acrolein: a novel marker of oxidative stress in Alzheimer’s disease. J. Neurochem. 72, 751–756.
- , , , and (1992) Acrolein initiates rat urinary bladder carcinogenesis. Cancer Res. 52, 3577–3581.
- , and (1980) Glutathione and ascorbate during ischemia and postischemic reperfusion in rat brain. J. Neurochem. 35, 1242–1245.
- , , , and (1995) Dietary antioxidants and cigarette smoke-induced biomolecular damage: a complex interaction. Am. J. Clin. Nutr. 62, 1490S–1500S.
- , and (1991) Chemistry and biochemistry of 4-hydroxynonenal, malonaldehyde and related aldehydes. Free Radic. Biol. Med. 11, 81–128.
- and (2005) Current status of clinical trials for acute spinal cord injury. Injury 36(Suppl 2), B113–B122.
- , , and (2006) Acrolein is a major cigarette-related lung cancer agent: Preferential binding at p53 mutational hotspots and inhibition of DNA repair. Proc. Natl Acad. Sci. USA 103, 15404–15409.
- , , , , and (1991) Aldehydes: occurrence, carcinogenic potential, mechanism of action and risk assessment. Mutat. Res. 259, 363–385.
- , , , , and (1995) Failure of methylprednisolone to improve the outcome of spinal cord injuries. American Surgeon 61, 659–663.
- and (1995) Fate and effects of acrolein. Rev. Environ. Contam. Toxicol. 144, 95–146.
- (1989) Free radicals and CNS injury. Crit. Care Clin. 5, 793–805.
- (1991) Inhibition of lipid peroxidation in CNS trauma. J. Neurotrauma 8, S31–S40; discussion S41.
- (1996) Lipid peroxidation. Adv. Neurol. 71, 247–257; discussion 247–258.
- and (1993) Free radicals in CNS injury. Res. Publ. Assoc. Res. Nerv. Ment. Dis. 71, 81–105.
- and (2004) Neuroprotection and acute spinal cord injury: a reappraisal. NeuroRx 1, 80–100.
- and (1999) Free Radicals in Biology and Medicine. Oxford University Press, Oxford.
- , , , , and (2008a) Critical role of acrolein in secondary injury following ex vivo spinal cord trauma. J. Neurochem. 107, 712–721.
- , , , and (2008b) Hydralazine inhibits compression and acrolein-mediated injuries in ex vivo spinal cord. J. Neurochem. 104, 709–718.
- , , , and (1999) Acrolein causes inhibitor κB-independent decreases in nuclear factor kappa B activation in human lung adenocarcinoma (A549) cells. J. Biol. Chem. 247, 9200–9206.
- and (1998) Review of oxidative stress in brain and spinal cord injury: suggestions for pharmacological and nutritional management strategies. J. Spinal Cord Med. 21, 309–334.
- , and (2004a) Reactivity of hydrazinophthalazine drugs with the lipid peroxidation products acrolein and crotonaldehyde. Org. Biomol. Chem. 2, 2578–2584.
- , and (2004b) Strong protein adduct trapping accompanies abolition of acrolein-mediated hepatotoxicity by hydralazine in mice. J. Pharmacol. Exp. Ther. 310, 1003–1010.
- and (2000) The molecular effects of acrolein. Toxicol. Sci. 57, 6–15.
- , and (2004) Robbins & Cotran Pathologic Basis of Disease. Elsevier, Philadelphia.
- , and (2003) Induction of phase 2 enzymes by serum oxidized polyamines through activation of Nrf2: effect of the polyamine metabolite acrolein. Biochem. Biophys. Res. Commun. 305, 662–670.
- , , and (2007) Pitfalls in treatment of acute cervical spinal cord injury using high-dose methylprednisolone: a retrospect audit of 111 patients. Surg. Neurol. 68, S37–S41.
- , and (2006a) Hydralazine rescues PC12 cells from acrolein-mediated death. J. Neurosci. Res. 84, 219–227.
- , , and (2006b) Acrolein-mediated mechanisms of neuronal death. J. Neurosci. Res. 84, 209–218.
- , and (2005) Glutathione and ascorbic acid enhance recovery of Guinea pig spinal cord white matter following ischemia and acrolein exposure. Pathobiology 72, 171–178.
- , and (2001) Acrolein is increased in Alzheimer’s disease brain and is toxic to primary hippocampal cultures. Neurobiol. Aging 22, 187–194.
- , , , and (2002) Effect of glutathione augmentation on lipid peroxidation after spinal cord injury. J. Neurotrauma 19, 763–775.
- and (2004) Acrolein induces axolemmal disruption, oxidative stress, and mitochondrial impairment in spinal cord tissue. Neurochem. Int. 44, 475–486.
- and (2005) Acrolein induces oxidative stress in brain mitochondria. Neurochem. Int. 46, 243–252.
- , and (2005a) Acrolein-induced cell death in PC12 cells: role of mitochondria-mediated oxidative stress. Neurochem. Int. 47, 449–457.
- , and (2005b) Accumulation of acrolein-protein adducts after traumatic spinal cord injury. Neurochem. Res. 30, 291–295.
- , , , , and (2001) Early complications of high-dose methylprednisolone sodium succinate treatment in the follow-up of acute cervical spinal cord injury. Spine 26, 426–430.
- and (1989) Metabolism of the Glutathione-Acrolein Adduct, S-(2-AldehydoEthyl)glutathione, by Rat Liver Alcohol and Aldehyde Dehydrogenase. J. Pharmacol. Exp. Ther. 251, 193–198.
- , and (2005) Aldehyde sources, metabolism, molecular toxicity mechanisms, and possible effects on human health. Crit. Rev. Toxicol. 35, 609–662.
- , , , , , and (1981) DNA-damaging activity in vivo and bacterial mutagenicity of sixteen hydrazine derivatives as related quantitatively to their carcinogenicity. Cancer Res. 41, 1469–1482.
- and (2001) Acrolein inhibits respiration in isolated brain mitochondria. Biochim. Biophys. Acta 1535, 145–152.
- , , , and (2001) Glutathione elevation and its protective role in acrolein-induced protein damage in synaptosomal membranes: relevance to brain lipid peroxidation in neurodegenerative disease. Neurochem. Int. 39, 141–149.
- (1981) Hydralazine and related compounds: chemistry, metabolism, and mode of action. Med. Res. Rev. 1, 73–96.
- , and (1994) Hydrazine-mediated DNA damage: role of hemoprotein, electron transport, and organic free radicals. Toxicol. Appl. Pharmacol. 125, 123–132.
- , , , , , and (2003) Increase in putrescine, amine oxidase, and acrolein in plasma of renal failure patients. Biochem. Biophys. Res. Commun. 305, 143–149.
- (2000) Oxidation of polyamines and brain injury. Neurochem. Res. 25, 471–490.
- , , , , , and (2007) In parkinsonian substantia nigra, alpha-synuclein is modified by acrolein, a lipid-peroxidation product, and accumulates in the dopamine neurons with inhibition of proeasome activity. J. Neural. Transm. 114, 1559–1567.
- (2004) The dynamics of axolemmal disruption in guinea pig spinal cord following compression. J. Neurocytol. 33, 203–211.
- and (1996) Compression injury of mammalian spinal cord in vitro and the dynamics of action potential conduction failure. J. Neurophysiol. 76, 1572–1580.
- and (2006) The role of acrolein in spinal cord injury. Appl. Neurol. 2, 22–27.
- and (2006) Conduction deficits and membrane disruption of spinal cord axons as a function of magnitude and rate of strain. J. Neurophysiol. 95, 3384–3390.
- , , and (2000) Control of membrane sealing in injured mammalian spinal cord axons. J. Neurophysiol. 84, 1763–1769.
- , and (2002) Acrolein inflicts axonal membrane disruption and conduction loss in isolated guinea pig spinal cord. Neuroscience 115, 337–340.
- , and (1991) Na+-Ca2+ exchange mediates Ca2+ influx during anoxia in mammalian central nervous system white matter. Ann. Neurol. 30, 375–380.
- , , , and (2008) Early complications of high-dose methylprednisolone in acute spinal cord injury patients. Injury 39, 748–752.
- (2006) Review of treatment trials in human spinal cord injury: issues, difficulties, and recommendations. Neurosurgery 59, 957–982.
- and (2008) Genome-wide transcriptional responses to acrolein. Chem. Res. Toxicol. 21, 2245–2256.
- (1999) Current status of acrolein as a lipid peroxidation product. Trends Cardiovasc. Med. 9, 109–113.
- , , , , and (1998a) Acrolein is a product of lipid peroxidation reaction. Formation of free acrolein and its conjugate with lysine residues in oxidized low density lipoproteins. J. Biol. Chem. 273, 16058–16066.
- , , et al. (1998b) Protein-bound acrolein: potential markers for oxidative stress. Proc. Natl Acad. Sci. USA 95, 4882–4887.
- , , , , , and (2005) Inhibition of NFκB activation and IL-8 expression in human bronchial epithelial cells by acrolein. Antioxid. Redox Signal. 7, 25–31.
- and (1991) Hydralazine stimulates production of oxygen free radicals in Eagle’s medium and cultured fibroblasts. Free Radic. Biol. Med. 11, 149–155.
- , , and (1980) Genotoxicity of the antihypertensive drugs hydralazine and dihydralazine. Science 210, 329–330.
- (1989) Biological interactions of alpha,beta-unsaturated aldehydes. Free Radic. Biol. Med. 7, 333–349.
- , , , , and (2006) Aldehyde load in ischemia-reperfusion brain injury: neuroprotection by neutralization of reactive aldehydes with phenelzine. Brain Res. 1122, 184–190.
- , and (2007) Role of peroxynitrite in secondary oxidative damage after spinal cord injury. J. Neurochem. 100, 639–649.
- (1993) Secondary injury mechanisms in acute spinal cord injury. J. Emergency Med. 11, 13–22.

1471-4159/asset/olbannerleft.gif?v=1&s=4636ca86ad7e40d133e71d09a5d759010472e0c2)
1471-4159/asset/olbannerright.gif?v=1&s=38094197c2d87aeb3b86aa293b5858c5c15cca29)
