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  • Agani F. H., Pichiule P., Chavez J. C. and LaManna J. C. (2000) The role of mitochondria in the regulation of hypoxia-inducible factor 1 expression during hypoxia. J. Biol. Chem. 275, 3586335867.
  • Atwood C. S., Scarpa R. C., Huang X., Moir R. D., Jones W. D., Fairlie D. P., Tanzi R. E. and Bush A. I. (2000) Characterization of copper interactions with Alzheimer amyloid beta peptides: identification of an attomolar-affinity copper binding site on amyloid beta1-42. J. Neurochem. 75, 12191233. Available at: http://www.strokecenter.org/patients/stats.htm.
  • Baranova O., Miranda L. F., Pichiule P., Dragatsis I., Johnson R. S. and Chavez J. C. (2007) Neuron-specific inactivation of the hypoxia inducible factor 1alpha increases brain injury in a mouse model of transient focal cerebral ischemia. J. Neurosci. 27, 63206332.
  • Beal M. F. (2003) Mitochondria, oxidative damage, and inflammation in Parkinson's disease. Ann. N.Y. Acad. Sci. 991, 120131.
  • Beal M. F., Brouillet E., Jenkins B. G. et al. (1993) Neurochemical and histologic characterization of striatal excitotoxic lesions produced by the mitochondrial toxin 3-nitropropionic acid. J. Neurosci. 13, 41814192.
  • Bell E. L., Klimova T. A., Eisenbart J., Moraes C. T., Murphy M. P., Budinger G. R. and Chandel N. S. (2007) The Qo site of the mitochondrial complex III is required for the transduction of hypoxic signaling via reactive oxygen species production. J. Cell Biol. 177, 10291036.
  • Ben-Shachar D., Eshel G., Finberg J. P. and Youdim M. B. (1991) The iron chelator desferrioxamine (Desferal) retards 6-hydroxydopamine-induced degeneration of nigrostriatal dopamine neurons. J. Neurochem. 56, 14411444.
  • Bergeron M., Yu A. Y., Solway K. E., Semenza G. L. and Sharp F. R. (1999) Induction of hypoxia-inducible factor-1 (HIF-1) and its target genes following focal ischaemia in rat brain. Eur. J. Neurosci. 11, 41594170.
  • Bergeron M., Gidday J. M., Yu A. Y., Semenza G. L., Ferriero D. M. and Sharp F. R. (2000) Role of hypoxia-inducible factor-1 in hypoxia-induced ischemic tolerance in neonatal rat brain. Ann. Neurol. 48, 285296.
  • Bernaudin M., Marti H. H., Roussel S., Divoux D., Nouvelot A., MacKenzie E. T. and Petit E. (1999) A potential role for erythropoietin in focal permanent cerebral ischemia in mice. J. Cereb. Blood Flow Metab. 19, 643651.
  • Bhattacharya S., Michels C. L., Leung M. K., Arany Z. P., Kung A. L. and Livingston D. M. (1999) Functional role of p35srj, a novel p300/CBP binding protein, during transactivation by HIF-1. Genes Dev. 13, 6475.
  • Bishop G. M., Robinson S. R., Liu Q., Perry G., Atwood C. S. and Smith M. A. (2002) Iron: a pathological mediator of Alzheimer disease? Dev. Neurosci. 24, 184187.
  • Bruick R. K. (2000) Expression of the gene encoding the proapoptotic Nip3 protein is induced by hypoxia. Proc. Natl Acad. Sci. USA 97, 90829087.
  • Brunelle J. K., Bell E. L., Quesada N. M., Vercauteren K., Tiranti V., Zeviani M., Scarpulla R. C. and Chandel N. S. (2005) Oxygen sensing requires mitochondrial ROS but not oxidative phosphorylation. Cell Metab. 1, 409414.
  • Cardoso S. M., Moreira P. I., Agostinho P., Pereira C. and Oliveira C. R. (2005) Neurodegenerative pathways in Parkinson’s disease: therapeutic strategies. Curr. Drug Targets CNS Neurol. Disord. 4, 405419.
  • Carrero P., Okamoto K., Coumailleau P., O’Brien S., Tanaka H. and Poellinger L. (2000) Redox-regulated recruitment of the transcriptional coactivators CREB-binding protein and SRC-1 to hypoxia-inducible factor 1alpha. Mol. Cell. Biol. 20, 402415.
  • Chandel N. S., Maltepe E., Goldwasser E., Mathieu C. E., Simon M. C. and Schumacker P. T. (1998) Mitochondrial reactive oxygen species trigger hypoxia-induced transcription. Proc. Natl Acad. Sci. USA 95, 1171511720.
  • Chandel N. S., McClintock D. S., Feliciano C. E., Wood T. M., Melendez J. A., Rodriguez A. M. and Schumacker P. T. (2000) Reactive oxygen species generated at mitochondrial complex III stabilize hypoxia-inducible factor-1alpha during hypoxia: a mechanism of O2 sensing. J. Biol. Chem. 275, 2513025138.
  • Chang S., Jiang X., Zhao C., Lee C. and Ferriero D. M. (2008) Exogenous low dose hydrogen peroxide increases hypoxia-inducible factor-1alpha protein expression and induces preconditioning protection against ischemia in primary cortical neurons. Neurosci. Lett. 441, 134138.
  • Chavez J. C., Agani F., Pichiule P. and LaManna J. C. (2000) Expression of hypoxia-inducible factor-1ain the brain of rats during chronic hypoxia. J. Appl. Physiol. 89, 19371942.
  • Cherny R. A., Atwood C. S., Xilinas M. E. et al. (2001) Treatment with a copper-zinc chelator markedly and rapidly inhibits beta-amyloid accumulation in Alzheimer’s disease transgenic mice. Neuron 30, 665676.
  • Crapper McLachlan D. R., Dalton A. J., Kruck T. P., Bell M. Y., Smith W. L., Kalow W. and Andrews D. F. (1991) Intramuscular desferrioxamine in patients with Alzheimer’s disease. Lancet 337, 13041308.
  • DeHaan C., Habibi-Nazhad B., Yan E., Salloum N., Parliament M. and Allalunis-Turner J. (2004) Mutation in mitochondrial complex I ND6 subunit is associated with defective response to hypoxia in human glioma cells. Mol. Cancer 3, 19.
  • Demougeot C., Bobillier-Chaumont S., Mossiat C., Marie C. and Berthelot A. (2004a) Effect of diets with different magnesium content in ischemic stroke rats. Neurosci. Lett. 362, 1720.
  • Demougeot C., Van Hoecke M., Bertrand N., Prigent-Tessier A., Mossiat C., Beley A. and Marie C. (2004b) Cytoprotective efficacy and mechanisms of the liposoluble iron chelator 2,2′-dipyridyl in the rat photothrombotic ischemic stroke model. J. Pharmacol. Exp. Ther. 311, 10801087.
  • Ebert B. L., Firth J. D. and Ratcliffe P. J. (1995) Hypoxia and mitochondrial inhibitors regulate expression of glucose transporter-1 via distinct Cis-acting sequences. J. Biol. Chem. 270, 2908329089.
  • Ehrenreich H., Hasselblatt M., Dembowski C. et al. (2002) Erythropoietin therapy for acute stroke is both safe and beneficial. Mol. Med. 8, 495505.
  • Feldser D., Agani F., Iyer N. V., Pak B., Ferreira G. and Semenza G. L. (1999) Reciprocal positive regulation of hypoxia-inducible factor 1a and insulin-like growth factor 2. Cancer Res. 59, 39153918.
  • Forsythe J. A., Jiang B. H., Iyer N. V., Agani F., Leung S. W., Koos R. D. and Semenza G. L. (1996) Activation of vascular endothelial growth factor gene transcription by hypoxia-inducible factor 1. Mol. Cell. Biol. 16, 46044613.
  • Freeman R. S. and Barone M. C. (2005) Targeting hypoxia-inducible factor (HIF) as a therapeutic strategy for CNS disorders. Curr. Drug Targets CNS Neurol. Disord. 4, 8592.
  • Freret T., Valable S., Chazalviel L., Saulnier R., Mackenzie E. T., Petit E., Bernaudin M., Boulouard M. and Schumann-Bard P. (2006) Delayed administration of deferoxamine reduces brain damage and promotes functional recovery after transient focal cerebral ischemia in the rat. Eur. J. Neurosci. 23, 17571765.
  • Furuichi T., Liu W., Shi H., Miyake M. and Liu K. J. (2005) Generation of hydrogen peroxide during brief oxygen-glucose deprivation induces preconditioning neuronal protection in primary cultured neurons. J. Neurosci. Res. 79, 816824.
  • Gerber H. P., Condorelli F., Park J. and Ferrara N. (1997) Differential transcriptional regulation of the two vascular endothelial growth factor receptor genes. Flt-1, but not Flk-1/KDR, is up-regulated by hypoxia. J. Biol. Chem. 272, 2365923667.
  • Graven K. K., Yu Q., Pan D., Roncarati J. S. and Farber H. W. (1999) Identification of an oxygen responsive enhancer element in the glyceraldehyde-3-phosphate dehydrogenase gene. Biochim. Biophys. Acta 1447, 208218.
  • Greenfield J. P., Gross R. S., Gouras G. K. and Xu H. (2000) Cellular and molecular basis of beta-amyloid precursor protein metabolism. Front. Biosci. 5, 7283.
  • Guo S., Miyake M., Liu K. J. and Shi H. (2009) Specific inhibition of hypoxia inducible factor 1 exaggerates cell injury induced by in vitro ischemia through deteriorating cellular redox environment. J. Neurochem. 108, 13091321.
  • Guzy R. D., Hoyos B., Robin E., Chen H., Liu L., Mansfield K. D., Simon M. C., Hammerling U. and Schumacker P. T. (2005) Mitochondrial complex III is required for hypoxia-induced ROS production and cellular oxygen sensing. Cell Metab. 1, 401408.
  • Hamrick S. E., McQuillen P. S., Jiang X., Mu D., Madan A. and Ferriero D. M. (2005) A role for hypoxia-inducible factor-1alpha in desferoxamine neuroprotection. Neurosci. Lett. 379, 96100.
  • Hanson L., Roeytenberg A., Martinez P. M. et al. (2009) Intranasal deferoxamine provides increased brain exposure and significant protection in rat ischemic stroke. J. Pharmacol. Exp. Ther. 330, 679686.
  • Hewitson K. S., McNeill L. A., Riordan M. V. et al. (2002) Hypoxia-inducible factor (HIF) asparagine hydroxylase is identical to factor inhibiting HIF (FIH) and is related to the cupin structural family. J. Biol. Chem. 277, 2635126355.
  • Hoyer S. (2004) Causes and consequences of disturbances of cerebral glucose metabolism in sporadic Alzheimer disease: therapeutic implications. Adv. Exp. Med. Biol. 541, 135152.
  • Huang L. E., Arany Z., Livingston D. M. and Bunn H. F. (1996) Activation of hypoxia-inducible transcription factor depends primarily upon redox-sensitive stabilization of its a subunit. J. Biol. Chem. 271, 3225332259.
  • Huang L. E., Gu J., Schau M. and Bunn H. F. (1998) Regulation of hypoxia-inducible factor 1a is mediated by an O2-dependent degradation domain via the ubiquitin–proteasome pathway. Proc. Natl Acad. Sci. USA 95, 79877992.
  • Ivan M., Kondo K., Yang H. et al. (2001) HIFalpha targeted for VHL-mediated destruction by proline hydroxylation: implications for O2 sensing. Science 292, 464468.
  • Jaakkola P., Mole D. R., Tian Y. M. et al. (2001) Targeting of HIF-alpha to the von Hippel-Lindau ubiquitylation complex by O2-regulated prolyl hydroxylation. Science 292, 468472.
  • Jiang B. H., Semenza G. L., Bauer C. and Marti H. H. (1996) Hypoxia-inducible factor 1 levels vary exponentially over a physiologically. Am. J. Physiol. 271, 11721180.
  • Jin K. L., Mao X. O. and Greenberg D. A. (2000) Vascular endothelial growth factor: direct neuroprotective effect in in vitro ischemia. Proc. Natl Acad. Sci. USA 97, 1024210247.
  • Kaluz S., Kaluzová M., Chrastina A., Olive P. L., Pastoreková S., Pastorek J., Lerman M. I. and Stanbridge E. J. (2002) Lowered oxygen tension induces expression of the hypoxia marker MN/carbonic anhydrase IX in the absence of hypoxia-inducible factor 1astabilization: a role for phosphatidylinositol 3′-kinase. Cancer Res. 62, 44694477.
  • Kaur D., Yantiri F., Rajagopalan S. et al. (2003) Genetic or pharmacological iron chelation prevents MPTP-induced neurotoxicity in vivo: a novel therapy for Parkinson’s disease. Neuron 37, 899909.
  • Klimova T. and Chandel N. S. (2008) Mitochondrial complex III regulates hypoxic activation of HIF. Cell Death Differ. 15, 660666.
  • Koivunen P., Hirsila M., Gunzler V., Kivirikko K. I. and Myllyharju J. (2004) Catalytic properties of the asparaginyl hydroxylase (FIH) in the oxygen sensing pathway are distinct from those of its prolyl 4-hydroxylases. J. Biol. Chem. 279, 98999904.
  • Kung A. L., Wang S., Klco J. M., Kaelin W. G. and Livingston D. M. (2000) Suppression of tumor growth through disruption of hypoxia-inducible transcription. Nat. Med. 6, 13351340.
  • Kuroki M., Voest E. E., Amano S. et al. (1996) Reactive oxygen intermediates increase vascular endothelial growth factor expression in vitro and in vivo. J. Clin. Invest. 98, 16671675.
  • Lan J. and Jiang D. H. (1997) Desferrioxamine and vitamin E protect against iron and MPTP-induced neurodegeneration in mice. J. Neural Transm. 104, 469481.
  • Lando D., Peet D. J., Gorman J. J., Whelan D. A., Whitelaw M. L. and Bruick R. K. (2002) FIH-1 is an asparaginyl hydroxylase enzyme that regulates the transcriptional activity of hypoxia-inducible factor. Genes Dev. 16, 14661471.
  • Larsson E., Nanobashvili A., Kokaia Z. and Lindvall O. (1999) Evidence for neuroprotective effects of endogenous brain-derived neurotrophic factor after global forebrain ischemia in rats. J. Cereb. Blood Flow Metab. 19, 12201228.
  • Lee P. J., Jiang B. H., Chin B. Y., Iyer N. V., Alam J., Semenza G. L. and Choi A. M. (1997) Hypoxia-inducible factor-1 mediates transcriptional activation of the heme oxygenase-1 gene in response to hypoxia. J. Biol. Chem. 272, 53755381.
  • Lee C., Kim S. J., Jeong D. G., Lee S. M. and Ryu S. E. (2003) Structure of human FIH-1 reveals a unique active site pocket and interaction sites for HIF-1 and von Hippel-Lindau. J. Biol. Chem. 278, 75587563.
  • Lee D. W., Rajagopalan S., Siddiq A., Gwiazda R., Yang L., Beal M. F., Ratan R. R. and Andersen J. K.. (2009) Inhibition of prolyl hydroxylase protects against MPTP-induced neurotoxicity: model for the potential involvement of the hypoxia-inducible factor pathway in Parkinson’s disease. J. Biol. Chem. 284, 2906529076.
  • Li J., Zhang X., Sejas D. P., Bagby G. C. and Pang Q. (2004) Hypoxia-induced nucleophosmin protects cell death through inhibition of p53. J. Biol. Chem. 279, 4127541279.
  • Li X., Lu F., Wang J. Z. and Gong C. X. (2006) Concurrent alterations of O-GlcNAcylation and phosphorylation of tau in mouse brains during fasting. Eur. J. Neurosci. 23, 20782086.
  • Li Y. X., Ding S. J., Xiao L., Guo W. and Zhan Q. (2008) Desferoxamine preconditioning protects against cerebral ischemia in rats by inducing expressions of hypoxia inducible factor 1 alpha and erythropoietin. Neurosci. Bull. 24, 8995.
  • Li Y., Lim S., Hoffman D., Aspenstrom P., Federoff H. J. and Rempe D. A. (2009) HUMMR, a hypoxia- and HIF-1alpha-inducible protein, alters mitochondrial distribution and transport. J. Cell Biol. 185, 10651081.
  • De Lima M. N., Dias C. P., Torres J. P. et al. (2008) Reversion of age-related recognition memory impairment by iron chelation in rats. Neurobiol. Aging 29, 10521059.
  • Lin M. T. and Beal M. F. (2006) Mitochondrial dysfunction and oxidative stress in neurodegenerative diseases. Nature 443, 787795.
  • Liu F., Iqbal K., Grundke-Iqbal I., Hart G. W. and Gong C. X. (2004) O-GlcNAcylation regulates phosphorylation of tau: a mechanism involved in Alzheimer’s disease. Proc. Natl Acad. Sci. USA 101, 1080410809.
  • Liu J., Narasimhan P., Yu F. and Chan P. H. (2005) Neuroprotection by hypoxic preconditioning involves oxidative stress-mediated expression of hypoxia-inducible factor and erythropoietin. Stroke 36, 12641269.
  • Liu Y., Liu F., Iqbal K., Grundke-Iqbal I. and Gong C. X. (2008) Decreased glucose transporters correlate to abnormal hyperphosphorylation of tau in Alzheimer disease. FEBS Lett. 582, 359364.
  • Lo E. H., Dalkara T. and Moskowitz M. A. (2003) Mechanisms, challenges and opportunities in stroke. Nat. Rev. Neurosci. 4, 399415.
  • Mahon P. C., Hirota K. and Semenza G. L. (2001) FIH-1: a novel protein that interacts with HIF-1alpha and VHL to mediate repression of HIF-1 transcriptional activity. Genes Dev. 15, 26752686.
  • Mansfield K. D., Guzy R. D., Pan Y., Young R. M., Cash T. P., Schumacker P. T. and Simon M. C. (2005) Mitochondrial dysfunction resulting from loss of cytochrome c impairs cellular oxygen sensing and hypoxic HIF-α activation. Cell Metab. 1, 393399.
  • Marti H. J., Bernaudin M., Bellail A., Schoch H., Euler M., Petit E. and Risau W. (2000) Hypoxia-induced vascular endothelial growth factor expression precedes neovascularization after cerebral ischemia. Am. J. Pathol. 156, 965976.
  • Maxwell P. H., Wiesener M. S., Chang G. W. et al. (1999) The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis. Nature 399, 271275.
  • McNeill L. A., Hewitson K. S., Claridge T. D., Seibel J. F., Horsfall L. E. and Schofield C. J. (2002) Hypoxia-inducible factor asparaginyl hydroxylase (FIH-1) catalyses hydroxylation at the beta-carbon of asparagine-803. Biochem. J. 367, 571575.
  • Migliore L. and Coppedè F. (2009) Environmental-induced oxidative stress in neurodegenerative disorders and aging. Mutat. Res. 674, 7384.
  • Mole D. R., Maxwell P. H., Pugh C. W. and Ratcliffe P. J. (2001) Regulation of HIF by the von Hippel-Lindau tumour suppressor: implications for cellular oxygen sensing. IUBMB Life 52, 4347.
  • Moreira P. I., Cardoso S. M., Santos M. S. and Oliveira C. R. (2006a) The key role of mitochondria in Alzheimer’s disease. J. Alzheimers Dis. 9, 101110.
  • Moreira P. I., Honda K., Zhu X., Nunomura A., Casadesus G., Smith M. A. and Perry G. (2006b) Brain and brawn: parallels in oxidative strength. Neurology 66, 97101.
  • Moreira P. I., Zhu X., Lee H. G., Honda K., Smith M. A. and Perry G. (2006c) The (un)balance between metabolic and oxidative abnormalities and cellular compensatory responses in Alzheimer disease. Mech. Ageing Dev. 127, 501506.
  • Moreira P. I., Santos M. S. and Oliveira C. R. (2007) Alzheimer’s disease: a lesson from mitochondrial dysfunction. Antioxid. Redox Signal. 9, 16211630.
  • Moreira P. I., Duarte A. I., Santos M. S., Rego A. C. and Oliveira C. R. (2009) An integrative view of the role of oxidative stress, mitochondria and insulin in Alzheimer’s disease. J. Alzheimers Dis. 16, 741761.
  • Mu D., Chang Y. S., Vexler Z. S. and Ferriero D. M. (2005) Hypoxia-inducible factor 1alpha and erythropoietin upregulation with deferoxamine salvage after neonatal stroke. Exp. Neurol. 195, 407415.
  • Mukhopadhyay C. K., Mazumder B. and Fox P. L. (2000) Role of hypoxia-inducible factor-1 in transcriptional activation of ceruloplasmin by iron deficiency. J. Biol. Chem. 275, 2104821054.
  • Zur Nedden S., Tomaselli B. and Baier-Bitterlich G. (2008) HIF-1 alpha is an essential effector for purine nucleoside-mediated neuroprotection against hypoxia in PC12 cells and primary cerebellar granule neurons. J. Neurochem. 105, 19011914.
  • Nguyen T., Hamby A. and Massa S. M. (2005) Clioquinol down-regulates mutant huntingtin expression in vitro and mitigates pathology in a Huntington’s disease mouse model. Proc. Natl Acad. Sci. USA 102, 1184011845.
  • Nunomura A., Moreira P. I., Lee H. G., Zhu X., Castellani R. J., Smith M. A. and Perry G. (2007) Neuronal death and survival under oxidative stress in Alzheimer and Parkinson diseases. CNS Neurol. Disord. Drug Targets 6, 411423.
  • O’Rourke J. F., Pugh C. W., Bartlett S. M. and Ratcliffe P. J. (1996) Identification of hypoxically inducible mRNAs in HeLa cells using differential-display PCR. Role of hypoxia-inducible factor-1. Eur. J. Biochem. 241, 403410.
  • Palmer C., Roberts R. L. and Bero C. (1994) Deferoxamine posttreatment reduces ischemic brain injury in neonatal rats. Stroke 25, 10391045.
  • Palmer L. A., Semenza G. L., Stoler M. H. and Johns R. A. (1998) Hypoxia induces type II NOS gene expression in pulmonary artery endothelial cells via HIF-1. Am. J. Physiol. 274, 212219.
  • Panov A. V., Gutekunst C. A., Leavitt B. R., Hayden M. R., Burke J. R., Strittmatter W. J. and Greenamyre J. T. (2002) Early mitochondrial calcium defects in Huntington’s disease are a direct effect of polyglutamines. Nat. Neurosci. 5, 731736.
  • Pialoux V., Mounier R., Brown A. D., Steinback C. D., Rawling J. M. and Poulin M. J. (2009) Relationship between oxidative stress and HIF-1 alpha mRNA during sustained hypoxia in humans. Free Radic. Biol. Med. 46, 321326.
  • Piret J. P., Lecocq C., Toffoli S., Ninane N., Raes M. and Michiels C. (2004) Hypoxia and CoCl2 protect HepG2 cells against serum deprivation- and t-BHP-induced apoptosis: a possible anti-apoptotic role for HIF-1. Exp. Cell Res. 295, 340349.
  • Prass K., Ruscher K., Karsch M., Isaev N., Megow D., Priller J., Scharff A., Dirnagl U. and Meisel A. (2002) Desferrioxamine induces delayed tolerance against cerebral ischemia in vivo and in vitro. J. Cereb. Blood Flow Metab. 22, 520525.
  • Przedborski S., Vial M. and Jackson-Lewis V. (2003) Neurodegeneration: what is it and where are we? J. Clin. Invest. 111, 310.
  • Pugh C. W., O’Rourke J. F., Nagao M., Gleadle J. M. and Ratcliffe P. J. (1997) Activation of hypoxia-inducible factor-1; definition of regulatory domains within the alpha subunit. J. Biol. Chem. 272, 1120511214.
  • Rami A., Bechmann I. and Stehle J. H. (2008) Exploiting endogenous anti-apoptotic proteins for novel therapeutic strategies in cerebral ischemia. Prog. Neurobiol. 85, 273296.
  • Ravati A., Ahlemeyer B., Becker A. and Krieglstein J. (2000) Preconditioning-induced neuroprotection is mediated by reactive oxygen species. Brain Res. 866, 2332.
  • Ritchie C. W., Bush A. I., Mackinnon A. et al. (2003) Metal-protein attenuation with iodochlorhydroxyquin (clioquinol) targeting Abeta amyloid deposition and toxicity in Alzheimer disease: a pilot phase 2 clinical trial. Arch. Neurol. 60, 16851691.
  • Ross C. A., Becher M. W., Colomer V., Engelender S., Wood J. D. and Sharp A. H. (1997) Huntington’s disease and dentatorubral-pallidoluysian atrophy: proteins, pathogenesis and pathology. Brain Pathol. 7, 10031016.
  • Rottkamp C. A., Raina A. K., Zhu X., Gaier E., Bush A. I., Atwood C. S., Chevion M., Perry G. and Smith M. A. (2001) Redox-active iron mediates amyloid-beta toxicity. Free Radic. Biol. Med. 30, 447450.
  • Ruscher K., Isaev N., Trendelenburg G., Weih M., Iurato L., Meisel A. and Dirnagl U. (1998) Induction of hypoxia inducible factor 1 by oxygen glucose deprivation is attenuated by hypoxic preconditioning in rat cultured neurons. Neurosci. Lett. 254, 117120.
  • Sadamoto Y., Igase K., Sakanaka M., Sato K., Otsuka H., Sakaki S., Masuda S. and Sasaki R. (1998) Erythropoietin prevents place navigation disability and cortical infarction in rats with permanent occlusion of the middle cerebral artery. Biochem. Biophys. Res. Commun. 253, 2632.
  • Safran M. and Kaelin W. G. Jr. (2003) HIF hydroxylation and the mammalian oxygen-sensing pathway. J. Clin. Investig. 111, 779783.
  • Sakanaka M., Wen T. C., Matsuda S., Masuda S., Morishita E., Nagao M. and Sasaki R. (1998) In vivo evidence that erythropoietin protects neurons from ischemic damage. Proc. Natl Acad. Sci. USA 95, 46354640.
  • Salceda S. and Caro J. (1997) Hypoxia-inducible factor 1α (HIF-1α) protein is rapidly degraded by the ubiquitin-proteasome system under normoxic conditions. J. Biol. Chem. 272, 2264222647.
  • Sanjuán-Pla A., Cervera A. M., Apostolova N., Garcia-Bou R., Victor V. M., Murphy M. P. and McCreath K. J. (2005) A targeted antioxidant reveals the importance of mitochondrial reactive oxygen species in the hypoxic signaling of HIF-1alpha. FEBS Lett. 579, 26692674.
  • Sasabe E., Tatemoto Y., Li D., Yamamoto T. and Osaki T. (2005) Mechanism of HIF-1alpha-dependent suppression of hypoxia-induced apoptosis in squamous cell carcinoma cells. Cancer Sci. 96, 394402.
  • Sayre L. M., Moreira P. I., Smith M. A. and Perry G. (2005) Metal ions and oxidative protein modification in neurological disease. Ann. Ist. Super. Sanita. 41, 143164.
  • Schabitz W. R., Schwab S., Spranger M. and Hacke W. (1997) Intraventricular brain-derived neurotrophic factor reduces infarct size after focal cerebral ischemia in rats. J. Cereb. Blood Flow Metab. 17, 500506.
  • Schabitz W. R., Sommer C., Zoder W., Kiessling M., Schwaninger M. and Schwab S. (2000) Intravenous brain-derived neurotrophic factor reduces infarct size and counterregulates Bax and Bcl-2 expression after temporary focal cerebral ischemia. Stroke 31, 22122217.
  • Scheepers A., Joost H. G. and Schurmann A. (2004) The glucose transporter families SGLT and GLUT: molecular basis of normal and aberrant function. J. Parenter. Enteral Nutr. 28, 364371.
  • Schubert D., Soucek T. and Blouw B. (2009) The induction of HIF-1 reduces astrocyte activation by amyloid beta peptide. Eur. J. Neurosci. 29, 13231334.
  • Selkoe D. J. (2001) Alzheimer’s disease results from the cerebral accumulation and cytotoxicity of amyloid beta-protein. J. Alzheimers Dis. 3, 7580.
  • Semenza G. L. (1999) Regulation of mammalian O2 homeostasis by hypoxia-inducible factor 1. Annu. Rev. Cell Dev. Biol. 15, 551578.
  • Semenza G. L. (2000a) HIF-1: mediator of physiological and pathophysiological responses to hypoxia. J. Appl. Physiol. 88, 14741480.
  • Semenza G. L. (2000b) Surviving ischemia: adaptive responses mediated by hypoxia-inducible factor 1. J. Clin. Invest. 106, 809812.
  • Semenza G. L. (2002) Signal transduction to hypoxia-inducible factor 1. Biochem. Pharmacol. 64, 993998.
  • Semenza G. L., Roth P. H., Fang H. M. and Wang G. L. (1994) Transcriptional regulation of genes encoding glycolytic enzymes by hypoxia-inducible factor 1. J. Biol. Chem. 269, 2375723763.
  • Sharp F. R. and Bernaudin M. (2004) HIF1 and oxygen sensing in the brain. Nat. Rev. Neurosci. 5, 437448.
  • Sharp F. R., Bergeron M. and Bernaudin M. (2001) Hypoxia-inducible factor in brain. Adv. Exp. Med. Biol. 502, 273291.
  • Sharp F. R., Ran R., Lu A., Tang Y., Strauss K. I., Glass T., Ardizzone T. and Bernaudin M. (2004) Hypoxic preconditioning protects against ischemic brain injury. NeuroRx 1, 2635.
  • Shi Q., Zhang P., Zhang J., Chen X., Lu H., Tian Y., Parker T. L. and Liu Y.. (2009) Adenovirus-mediated brain-derived neurotrophic factor expression regulated by hypoxia response element protects brain from injury of transient middle cerebral artery occlusion in mice. Neurosci. Lett. 465, 220225.
  • Siddiq A., Ayoub I. A., Chavez J. C. et al. (2005) Hypoxia-inducible factor prolyl 4-hydroxylase inhibition. A target for neuroprotection in the central nervous system. J. Biol. Chem. 280, 4173241743.
  • Siddiq A., Aminova L. R. and Ratan R. R. (2008) Prolyl 4-hydroxylase activity-responsive transcription factors: from hydroxylation to gene expression and neuroprotection. Front. Biosci. 13, 28752887.
  • Sirén A. L., Fratelli M., Brines M. et al. (2001) Erythropoietin prevents neuronal apoptosis after cerebral ischemia and metabolic stress. Proc. Natl Acad. Sci. USA 98, 40444049.
  • Sofic E., Riederer P., Heinsen H., Beckmann H., Reynolds G. P., Hebenstreit G. and Youdim M. B. (1988) Increased iron (III) and total iron content in post mortem substantia nigra of parkinsonian brain. J. Neural Transm. 74, 199205.
  • Soucek T., Cumming R., Dargusch R., Maher P. and Schubert D. (2003) The regulation of glucose metabolism by HIF-1 mediates a neuroprotective response to amyloid beta peptide. Neuron 39, 4356.
  • Sowter H. M., Ratcliffe P. J., Watson P., Greenberg A. H. and Harris A. L. (2001) HIF-1-dependent regulation of hypoxic induction of the cell death factors BNIP3 and NIX in human tumors. Cancer Res. 61, 66696673.
  • Srinivas V., Leshchinsky I., Sang N., King M. P., Minchenko A. and Caro J. (2001) Oxygen sensing and HIF-1 activation does not require an active mitochondrial respiratory chain electron-transfer pathway. J. Biol. Chem. 276, 2199521998.
  • Tabrizi S. J., Workman J., Hart P. E., Mangiarini L., Mahal A., Bates G., Cooper J. M. and Schapira A. H. (2000) Mitochondrial dysfunction and free radical damage in the Huntington R6/2 transgenic mouse. Ann. Neurol. 47, 8086.
  • Tacchini L., Bianchi L., Bernelli-Zazzera A. and Cairo G. (1999) Transferrin receptor induction by hypoxia. HIF-1-mediated transcriptional activation and cell-specific post-transcriptional regulation. J. Biol. Chem. 274, 2414224146.
  • Takahashi Y., Takahashi S., Shiga Y., Yoshimi T. and Miura T. (2000) Hypoxic induction of prolyl 4-hydroxylase a(I) in cultured cells. J. Biol. Chem. 275, 1413914146.
  • Tazuke S. I., Mazure N. M., Sugawara J. et al. (1998) Hypoxia stimulates insulin-like growth factor binding protein 1 (IGFBP-1) gene expression in HepG2 cells: a possible model for IGFBP-1 expression in fetal hypoxia. Proc. Natl Acad. Sci. USA 95, 1018810193.
  • Tupitsyna T. V., Slominskiĭ P. A., Shadrina M. I., Shetova I. M., Skvortsova V. I. and Limborskaia S. A. (2006) Association of the IVS9-675C>A polymorphism of the HIF-1alpha gene with acute ischemic stroke in the Moscow population. Genetika 42, 858861.
  • Vaux E. C., Metzen E., Yeates K. M. and Ratcliffe P. J. (2001) Regulation of hypoxia-inducible factor is preserved in the absence of a functioning mitochondrial respiratory chain. Blood 98, 296302.
  • Wang G. L. and Semenza G. L. (1993) Characterization of hypoxia-inducible factor 1 and regulation of DNA binding activity by hypoxia. J. Biol. Chem. 268, 2151321518.
  • Wang G. L., Jiang B. H., Rue E. A. and Semenza G. L. (1995) Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension. Proc. Natl Acad. Sci. USA 92, 55105514.
  • Yang Y. T., Ju T. C. and Yang D. I. (2005) Induction of hypoxia inducible factor-1 attenuates metabolic insults induced by 3-nitropropionic acid in rat C6 glioma cells. J. Neurochem. 93, 513525.
  • Youdim M. B., Ben-Shacher D. and Reiderer P. (1993) The possible role of iron in the etiopathology of Parkinson’s disease. Mov. Disord. 8, 112.
  • Zaman K., Ryu H., Hall D. et al. (1999) Protection from oxidative stress-induced apoptosis in cortical neuronal cultures by iron chelators is associated with enhanced DNA binding of hypoxia-inducible factor-1 and ATF-1/CREB and increased expression of glycolytic enzymes, p21 (waf1/cip1), and erythropoietin. J. Neurosci. 19, 98219830.
  • Zecca L., Youdim M. B., Riederer P., Connor J. R. and Crichton R. R. (2004) Iron, brain ageing and neurodegenerative disorders. Nat. Rev. Neurosci. 5, 863873.
  • Zhang D. X. and Gutterman D. D. (2007) Mitochondrial reactive oxygen species-mediated signaling in endothelial cells. Am. J. Physiol. Heart Circ. Physiol. 292, 20232031.
  • Zhou D., Matchett G. A., Jadhav V., Dach N. and Zhang J. H. (2008) The effect of 2-methoxyestradiol, a HIF-1alpha inhibitor, in global cerebral ischemia in rats. Neurol. Res. 30, 268271.
  • Zipp F. and Aktas O. (2006) The brain as a target of inflammation: common pathways link inflammatory and neurodegenerative diseases. Trends Neurosci. 29, 518527.