Energy substrate availability as a determinant of neuronal resting potential, GABA signaling and spontaneous network activity in the neonatal cortex in vitro
Article first published online: 24 NOV 2009
© 2009 The Authors. Journal Compilation © 2009 International Society for Neurochemistry
Journal of Neurochemistry
Volume 112, Issue 4, pages 900–912, February 2010
How to Cite
Holmgren, C. D., Mukhtarov, M., Malkov, A. E., Popova, I. Y., Bregestovski, P. and Zilberter, Y. (2010), Energy substrate availability as a determinant of neuronal resting potential, GABA signaling and spontaneous network activity in the neonatal cortex in vitro. Journal of Neurochemistry, 112: 900–912. doi: 10.1111/j.1471-4159.2009.06506.x
- Issue published online: 20 JAN 2010
- Article first published online: 24 NOV 2009
- Received August 18, 2009; revised manuscript received November 11, 2009; accepted November 14, 2009.
Figure S1. eACSF induces outward baseline current. Baseline outward current was induced following exchange of ACSF for eACSF. Gramicidin perforated patch recordings in the same experiment as shown in Fig. 3a. The current trace is filtered at 0.2 Hz low-pass.
Figure S2. Oscillatory network activity induced by increased [K+]O in eACSF. Field recordings in CA3 (P4, mouse). GDPs disappeared following exchange of ACSF with eACSF. However, an increase in [K+]O to 5 mM in eACSF caused the re-appearance of GDP-like network oscillations. The voltage trace was filtered at 0.5 Hz high-pass and 20 Hz low-pass.
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