SEARCH

SEARCH BY CITATION

References

  • Arakane F., King S. R., Du Y., Kallen C. B., Walsh L. P., Watari H., Stocco D. M. and Strauss J. F. III (1997) Phosphorylation of steroidogenic acute regulatory protein (StAR) modulates its steroidogenic activity. J. Biol. Chem. 272, 3265632662.
  • Artemenko I., Zhao D., Hales D. B., Hales K. H. and Jefcoate C. R. (2001) Mitochondrial processing of newly synthesized steroidogenic acute regulatory Protein (StAR), but not total StAR, mediates cholesterol transfer to cytochrome P450 side chain cleavage enzyme in adrenal cells. J. Biol. Chem. 276, 4658346596.
  • Barbaccia M. L., Affricano D., Trabucchi M., Purdy R. H., Colombo G., Agabio R. and Gessa G. L. (1999) Ethanol markedly increases “GABAergic’’ neurosteroids in alcohol-preferring rats. Eur. J. Pharmacol. 384, R1R2.
  • Bose H. S., Whittal R. M., Huang M., Baldwin M. A. and Miller W. L. (2000) N-218 MLN64, a protein with StAR-like steroidogenic activity, is folded and cleaved similarly to StAR. Biochemistry 39, 1172211731.
  • Brownie A. C., Alfano J., Jefcoate C. R., Orme-Johnson W., Beinert H. and Simpson E. R. (1973) Effect of ACTH on adrenal mitochondrial cytochrome P-450 in rat. Ann. N. Y. Acad. Sci. 212, 344360.
  • Caron K. M., Soo S. C., Wetsel W. C., Stocco D. M., Clark B. J. and Parker K. L. (1997) Targeted disruption of the mouse gene encoding steroidogenic acute regulatory protein provides insights into congenital lipoid adrenal hyperplasia. Proc. Natl. Acad. Sci. USA 94, 1154011545.
  • Cole M. A., Kim P. J., Kalman B. A. and Spencer R. L. (2000) Dexamethasone suppression of corticosteroid secretion: evaluation of the site of action by receptor measures and functional studies. Psychoneuroendocrinology 25, 151167.
  • Concas A., Sogliano C., Porcu P., Marra C., Brundu A. and Biggio G. (2006) Neurosteroids in nicotine and morphine dependence. Psychopharmacology (Berl) 186, 281292.
  • Gililland K. R. and Finn D. A. (2007) The impact of gonadectomy and adrenalectomy on acute withdrawal severity in male and female C57BL/6J and DBA/2J mice following a single high dose of ethanol. Alcohol. Clin. Exp. Res. 31, 18461857.
  • Griffin L. D. and Mellon S. H. (2001) Biosynthesis of the neurosteroid 3 alpha-hydroxy-4-pregnen-20-one (3 alpha hp), a specific inhibitor of FSH release. Endocrinology 142, 46174622.
  • Hirani K., Sharma A. N., Jain N. S., Ugale R. R. and Chopde C. T. (2005) Evaluation of GABAergic neuroactive steroid 3α-hydroxy-5α-pregnane-20-one as a neurobiological substrate for the anti-anxiety effect of ethanol in rats. Psychopharmacology 180, 267278.
  • Holdstock L., Penland S. N., Morrow A. L. and De Wit H. (2006) Moderate doses of ethanol fail to increase plasma levels of neurosteroid 3α-hydroxy-5α-pregnan-20-one-like immunoreactivity in healthy men and women. Psychopharmacology 186, 442450.
  • Janis G. C., Devaud L. L., Mitsuyama H. and Morrow A. L. (1998) Effects of chronic ethanol consumption and withdrawal on the neuroactive steroid 3α-hydroxy-5α-pregnan-20-one in male and female rats. Alcohol. Clin. Exp. Res. 22, 20552061.
  • Jefcoate C. R. (2002) High-flux mitochondrial cholesterol trafficking, a specialized function of adrenal cortex. J. Clin. Invest. 110, 881890.
  • Jenkins J. S. and Connolly J. (1968) Adrenocortical response to ethanol in man. Br. Med. J. 2, 804805.
  • Jo Y., King S. R., Khan S. A. and Stocco D. M. (2005) Involvement of protein kinase C and cyclic adenosine 3′,5′-monophosphate-dependent kinase in steroidogenic acute regulatory protein expression and steroid biosynthesis in Leydig cells. Biol. Reprod. 73, 244255.
  • Khisti R. T., VanDoren M. J., O’Buckley T. K. and Morrow A. L. (2003) Neuroactive steroid 3α-hydroxy-5α-pregnan-20-one modulates ethanol-induced loss of righting reflex in rats. Brain Res. 980, 255265.
  • Khisti R. T., Boyd K. N., Kumar S. and Morrow A. L. (2005) Systemic ethanol administration elevates deoxycorticosterone levels and chronic ethanol exposure attenuates this response. Brain Res. 1049, 104111.
  • Kim Y., Ariyoshi N., Artemenko I., Elliot M. E., Bhattacharyya K. K. and Jefcoate C. R. (1997) Control of cholesterol access to cytochrome P450scc in rat adrenal cells mediated by regulation of the steroidogenic acute regulatory protein. Steroids 62, 1020.
  • Kraulis I., Foldes G., Traikov H., Dubrovsky B. and Birmingham M. K. (1975) Distribution, metabolism and biological activity of deoxycorticosterone in the central nervous system. Brain Res. 88, 114.
  • Kumar S., Sieghart W. and Morrow A. L. (2002) Association of protein kinase C with GABAA receptors containing α1 and α4 subunits in the cerebral cortex: selective effects of chronic ethanol consumption. J. Neurochem. 82, 110117.
  • Lacapere J. J. and Papadopoulos V. (2003) Peripheral-type benzodiazepine receptor: structure and function of a cholesterol-binding protein in steroid and bile acid biosynthesis. Steroids 68, 569585.
  • Lee S., Selvage D., Hansen K. and Rivier C. (2004) Site of action of acute alcohol administration in stimulating the rat hypothalamic-pituitary-adrenal axis: comparison between the effect of systemic and intracerebroventricular injection of this drug on pituitary and hypothalamic responses. Endocrinology 145, 44704479.
  • Li X., Bertics P. J. and Karavolas H. J. (1997) Regional distribution of cytosolic and particulate 5alpha-dihydroprogesterone 3alpha-hydroxysteroid oxidoreductases in female rat brain. J. Steroid Biochem. Mol. Biol. 60, 311318.
  • Lin D., Sugawara T., Strauss J. F. III, Clark B. J., Stocco D. M., Saenger P., Rogol A. and Miller W. L. (1995) Role of steroidogenic acute regulatory protein in adrenal and gonadal steroidogenesis. Science 267, 18281831.
  • Marx C. E., VanDoren M. J., Duncan G. E., Lieberman J. A. and Morrow A. L. (2003) Olanzapine and clozapine increase the GABAergic neuroactive steroid allopregnanolone in rodents. Neuropsychopharmacology 28, 113.
  • Matthews D. B., Morrow A. L., Tokunaga S. and McDaniel J. R. (2002) Acute ethanol administration and acute allopregnanolone administration impair spatial memory in the Morris water task. Alcohol. Clin. Exp. Res. 26, 17471751.
  • Mellon S. H. and Deschepper C. F. (1993) Neurosteroid biosynthesis: genes for adrenal steroidogenic enzymes are expressed in the brain. Brain Res. 629, 283292.
  • Miller W. L. (1988) Molecular biology of steroid hormone synthesis. Endoc. Rev. 9, 295318.
  • Miller W. L. (1997) Congenital lipoid adrenal hyperplasia: the human gene knockout for the steroidogenic acute regulatory protein. J. Mol. Endocrinol. 19, 227240.
  • Miller W. L. (2007a) Mechanism of StAR’s regulation of mitochondrial cholesterol import. Mol. Cell. Endocrinol. 265–266, 4650.
  • Miller W. L. (2007b) StAR search – what we know about how the steroidogenic acute regulatory protein mediates mitochondrial cholesterol transport. Mol. Endocrinol. 21, 589601.
  • Miller W. L. (2007c) Steroidogenic acute regulatory protein (StAR), a novel mitochondrial cholesterol transporter. Biochim. Biophys. Acta 1771, 663676.
  • Morrow A. L. (2007) Recent developments in the significance and therapeutic relevance of neuroactive steroids – introduction to the special issue. Pharmacol. Ther. 116, 16.
  • Morrow A. L., Pace J. R., Purdy R. H. and Paul S. M. (1990) Characterization of steroid interactions with γ-aminobutyric acid receptor-gated chloride ion channels: evidence for multiple steroid recognition sites. Mol. Pharmacol. 37, 263270.
  • Morrow A. L., Janis G. C., VanDoren M. J., Matthews D. B., Samson H. H., Janak P. H. and Grant K. A. (1999) Neurosteroids mediate pharmacological effects of ethanol: a new mechanism of ethanol action? Alcohol. Clin. Exp. Res. 23, 19331940.
  • Morrow A. L., VanDoren M. J., Penland S. N. and Matthews D. B. (2001) The role of GABAergic neuroactive steroids in ethanol action, tolerance and dependence. Brain Res. Brain Res. Rev. 37, 98109.
  • Morrow A. L., Penland S., Khisti R. T., Porcu P. and Matthews D. B. (2005) GABAergic neuroactive steroids contribute to ethanol action in the CNS. Alcohol. Clin. Exp. Res. 29, 173A.
  • O’Dell L. E., Alomary A. A., Vallee M., Koob G. F., Fitzgerald R. L. and Purdy R. H. (2004) Ethanol-induced increases in neuroactive steroids in the rat brain and plasma are absent in adrenalectomized and gonadectomized rats. Eur. J. Pharmacol. 484, 241247.
  • Ogilvie K. M. and Rivier C. (1997) Gender differences in hypothalamic-pituitary-adrenal axis response to alcohol in the rat: activational role of gonadal steroids. Brain Res. 766, 1928.
  • Papadopoulos V., Baraldi M., Guilarte T. R. et al. (2006) Translocator protein (18 kDa): new nomenclature for the peripheral-type benzodiazepine receptor based on its structure and molecular function. Trends Pharmacol. Sci. 27, 402409.
  • Papadopoulos V., Liu J. and Culty M. (2007) Is there a mitochondrial signaling complex facilitating cholesterol import? Mol. Cell. Endocrinol. 265–266, 5964.
  • Pierucci-Lagha A., Covault J., Feinn R., Khisti R. T., Morrow A. L., Marx C. E., Shampine L. J. and Kranzler H. R. (2006) Subjective effects and changes in steroid hormone concentrations in humans following acute consumption of alcohol. Psychopharmacology 186, 451461.
  • Porcu P., Sogliano C., Ibba C., Piredda M., Tocco S., Marra C., Purdy R. H., Biggio G. and Concas A. (2004) Failure of γ-hydroxybutyric acid both to increase neuroactive steroid concentrations in adrenalectomized-orchiectomized rats and to induce tolerance to its steroidogenic effect in intact animals. Brain Res. 1012, 160168.
  • Porcu P., Rogers L. S. M., Morrow A. L. and Grant K. A. (2006) Plasma pregnenolone levels in cynomolgus monkeys following pharmacological challenges of the hypothalamic-pituitary-adrenal axis. Pharmacol. Biochem. Behav. 84, 618627.
  • Privalle C., Crivello J. and Jefcoate C. R. (1983) Regulation of intramitochondrial cholesterol transfer to side-chain cleavage cytochrome P-450 in rat adrenal gland. Proc. Natl. Acad. Sci. USA 80, 702706.
  • Purdy R. H., Morrow A. L., Moore P. H. Jr and Paul S. M. (1991) Stress-induced elevations of gamma-aminobutyric acid type A receptor-active steroids in the rat brain. Proc. Natl. Acad. Sci. USA 88, 45534557.
  • Richardson H. N., Lee S. Y., O’Dell L. E., Koob G. F. and Rivier C. L. (2008) Alcohol self-administration acutely stimulates the hypothalamic-pituitary-adrenal axis, but alcohol dependence leads to a dampened neuroendocrine state. Eur. J. Neurosci. 28, 16411653.
  • Rivier C., Rivier J. and Lee S. (1996) Importance of pituitary and brain receptors for corticotrophin-releasing factor in modulating alcohol-induced ACTH secretion in rat. Brain Res. 721, 8390.
  • Rupprecht R., Rammes G., Eser D. et al. (2009) Translocator protein (18 kD) as target for anxiolytics without benzodiazepine-like side effects. Science 325, 490493.
  • Sanna E., Talani G., Busonero F., Pisu M. G., Purdy R. H., Serra M. and Biggio G. (2004) Brain steroidogenesis mediates ethanol modulation of GABAA receptor activity in rat hippocampus. J. Neurosci. 24, 65216530.
  • Sarnyai Z., Shaham Y. and Heinrichs S. C. (2001) The role of corticotropin-releasing factor in drug addiction. Pharmacol. Rev. 53, 209243.
  • Serra M., Madau P., Chessa M. F. et al. (1999) 2-Phenyl-imidazo[1,2-a]pyridine derivatives as ligands for peripheral benzodiazepine receptors: stimulation of neurosteroid synthesis and anticonflict action in rats. Br. J. Pharmacol. 127, 177187.
  • Serra M., Pisu M. G., Floris I., Cara V., Purdy R. H. and Biggio G. (2003) Social isolation-induced increase in the sensitivity of rats to the steroidogenic effect of ethanol. J. Neurochem. 85, 257263.
  • Serra M., Mostallino M. C., Talani G. et al. (2006) Social isolation-induced increase in α4 and δ subunit gene expression is associated with a greater efficacy of ethanol on steroidogenesis and GABAA receptor function. J. Neurochem. 98, 122133.
  • Stocco D. M. (2000) The role of StAR protein in steroidogenesis: challenges for the future. J. Endocrinol. 164, 247253.
  • Stocco D. M. and Clark B. J. (1996) Regulation of the acute production of steroids in steroidogenic cells. Endocr. Rev. 17, 221244.
  • Stocco D. M., Wang X. J., Jo Y. and Manna P. R. (2005) Multiple signaling pathways regulating steroidogenesis and steroidogenic acute regulatory protein expression: more complicated than we thought. Mol. Endocrinol. 19, 26472659.
  • Tokunaga S., McDaniel J. R., Morrow A. L. and Matthews D. B. (2003) Effect of acute ethanol administration and acute allopregnanolone administration on spontaneous hippocampal pyramidal cell neural activity. Brain Res. 967, 273280.
  • VanDoren M. J., Matthews D. B., Janis G. C., Grobin A. C., Devaud L. L. and Morrow A. L. (2000) Neuroactive steroid 3α-hydroxy-5α-pregnan-20-one modulates electrophysiological and behavioral actions of ethanol. J. Neurosci. 20, 19821989.
  • Waltman C., Blevins L. S. J., Boyd G. and Wand G. S. (1993) The effects of mild ethanol intoxication on the hypothalamic-pituitary-adrenal axis in non-alcoholic men. J. Clin. Endocrinol. Metab. 77, 518522.
  • Wang M. D., Wahlstrom G. and Backstrom T. (1997) The regional brain distribution of the neurosteroids pregnenolone and pregnenolone sulfate following intravenous infusion. J. Steroid Biochem. Mol. Biol. 62, 299306.
  • Watari H., Arakane F., Moog-Lutz C., Kallen C. B., Tomasetto C., Gerton G. L., Rio M., Baker M. E. and Strauss J. F. III (1997) MLN64 contains a domain with homology to the steroidogenic acute regulatory protein (StAR) that stimulates steroidogenesis. Proc. Natl. Acad. Sci. USA 94, 84628467.
  • Wiebe J. P., De Gannes G. C. and Dallaire M. J. (1994) Synthesis of the allylic regulatory steroid, 3 alpha-hydroxy-4-pregnen-20-one, by rat granulosa cells and its regulation by gonadotropins. Biol. Reprod. 50, 956964.