Naturally occurring phytochemicals for the prevention of Alzheimer’s disease

Authors

  • Jiyoung Kim,

    1. Major in Biomodulation, Department of Agricultural Biotechnology, Research Institute for Agriculture and Life Sciences, Seoul National University, Seoul, Korea
    2. Department of Bioscience and Biotechnology, Bio/Molecular Informatics Center, Konkuk University, Seoul, Korea
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  • Hyong Joo Lee,

    1. Major in Biomodulation, Department of Agricultural Biotechnology, Research Institute for Agriculture and Life Sciences, Seoul National University, Seoul, Korea
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  • Ki Won Lee

    1. Department of Bioscience and Biotechnology, Bio/Molecular Informatics Center, Konkuk University, Seoul, Korea
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Address correspondence and reprint requests to Ki Won Lee, Department of Bioscience and Biotechnology, Konkuk University, 1 Hwayang-dong, Gwangjin-gu, Seoul 143-701, Korea. E-mail: kiwon@konkuk.ac.kr and Hyong Joo Lee, Major in Biomodulation, WCU, Department of Agricultural Biotechnology, Research Institute for Agriculture and Life Sciences, Seoul National University, 599 Gwangak-ro, Gwanak-gu, Seoul 151-921, Korea. E-mail: leehyjo@snu.ac.kr

Abstract

J. Neurochem. (2010) 112, 1415–1430.

Abstract

Alzheimer’s disease (AD) is an age-related neurodegenerative disease increasingly recognized as one of the most important medical problems affecting the elderly. Although a number of drugs, including several cholinesterase inhibitors and an NMDA receptor antagonist, have been approved for use, they have been shown to produce diverse side effects and yield relatively modest benefits. To overcome these limitations of current therapeutics for AD, extensive research and development are underway to identify drugs that are effective and free of undesirable side effects. Certain naturally occurring dietary polyphenolic phytochemicals have received considerable recent attention as alternative candidates for AD therapy. In particular, curcumin, resveratrol, and green tea catechins have been suggested to have the potential to prevent AD because of their anti-amyloidogenic, anti-oxidative, and anti-inflammatory properties. These polyphenolic phytochemicals also activate adaptive cellular stress responses, called ‘neurohormesis’, and suppress disease processes. In this commentary, we describe the amyloid-β-induced pathogenesis of AD, and summarize the intracellular and molecular targets of selected dietary phytochemicals that might slow the progression of AD.

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