Appendix S1. Supplementary Materials and Methods.

Figure S1. Line graph illustrating time course changes of (a) tcpCO2 and (b) tcpO2 following subcutaneous administration of vehicle, or 2-DG (200 mg/kg) in α-chloralose anaesthetized rats (n = 7). An initial 15-min baseline period was acquired before drugs were injected (vertical dotted line). Results are presented as percentage change relative to baseline values (100%). Horizontal dotted line represents threshold level as described by Cabrer et al. (2005) by which BOLD signal is lost if tcpCO2 levels exceed 20% above baseline (Ramos-Cabrer et al. 2005). Error bars show SEM.

As a service to our authors and readers, this journal provides supporting information supplied by the authors. Such materials are peer-reviewed and may be re-organized for online delivery, but are not copy-edited or typeset. Technical support issues arising from supporting information (other than missing files) should be addressed to the authors.

JNC_6671_sm_DataandFigureS1.doc115KSupporting info item

Please note: Wiley Blackwell is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.