Toll-like receptor 4 in CNS pathologies
Article first published online: 6 APR 2010
© 2010 The Authors. Journal Compilation © 2010 International Society for Neurochemistry
Journal of Neurochemistry
Volume 114, Issue 1, pages 13–27, July 2010
How to Cite
Buchanan, M. M., Hutchinson, M., Watkins, L. R. and Yin, H. (2010), Toll-like receptor 4 in CNS pathologies. Journal of Neurochemistry, 114: 13–27. doi: 10.1111/j.1471-4159.2010.06736.x
- Issue published online: 8 JUN 2010
- Article first published online: 6 APR 2010
- Received November 9, 2009; revised manuscript received March 15, 2010; accepted March 31, 2010.
- endogenous ligand;
- Toll-like receptor;
J. Neurochem. (2010) 114, 13–27.
The responses of the brain to infection, ischemia and trauma share remarkable similarities. These and other conditions of the CNS coordinate an innate immune response marked by activation of microglia, the macrophage-like cells of the nervous system. An important contributor to microglial activation is toll-like receptor 4, a pathogen-associated molecular pattern receptor known to initiate an inflammatory cascade in response to various CNS stimuli. The present review traces new efforts to characterize and control toll-like receptor 4 in inflammatory etiologies of the nervous system.