An apolipoprotein E4 fragment can promote intracellular accumulation of amyloid peptide beta 42
Version of Record online: 20 APR 2010
© 2010 The Authors. Journal Compilation © 2010 International Society for Neurochemistry
Journal of Neurochemistry
Special Issue: Introducing Preclinical Systematic Reviews
Volume 115, Issue 4, pages 873–884, November 2010
How to Cite
Dafnis, I., Stratikos, E., Tzinia, A., Tsilibary, E. C., Zannis, V. I. and Chroni, A. (2010), An apolipoprotein E4 fragment can promote intracellular accumulation of amyloid peptide beta 42. Journal of Neurochemistry, 115: 873–884. doi: 10.1111/j.1471-4159.2010.06756.x
- Issue online: 20 APR 2010
- Version of Record online: 20 APR 2010
- Received October 27, 2009; revised manuscript received April 9, 2010; accepted April 13, 2010.
Figure S1. Effect of WT apoE4 and truncated apoE4 forms, apoE4-185 and apoE4-165, on cellular APP, secreted sAPPa and secreted Ab levels in SK-N-SH or HEK293 cells expressing human APP.
Figure S2. Uptake of exogenous added Ab40 by HEK293 cells in the presence of WT apoE4 and truncated apoE4 forms apoE4-185 and apoE4-165.
Figure S3. Uptake of exogenous added Ab40 by SK-N-SH cells in the presence of WT apoE4 and truncated apoE4 form apoE4-165.
Figure S4. LRP1 and phospholipid levels in SK-N-SH cells incubated with WT and truncated apoE4 forms.
Figure S5. Determination of mitochondrial localization of Ab40 and Ab42 in SK-N-SH cells incubated with apoE4-165.
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