These authors contributed equally to this study.
Adaptive immune regulation of glial homeostasis as an immunization strategy for neurodegenerative diseases
Version of Record online: 26 MAY 2010
© 2010 The Authors. Journal Compilation © 2010 International Society for Neurochemistry
Journal of Neurochemistry
Volume 114, Issue 5, pages 1261–1276, September 2010
How to Cite
Kosloski, L. M., Ha, D. M., Hutter, J. A. L., Stone, D. K., Pichler, M. R., Reynolds, A. D., Gendelman, H. E. and Mosley, R. L. (2010), Adaptive immune regulation of glial homeostasis as an immunization strategy for neurodegenerative diseases. Journal of Neurochemistry, 114: 1261–1276. doi: 10.1111/j.1471-4159.2010.06834.x
- Issue online: 2 AUG 2010
- Version of Record online: 26 MAY 2010
- Received April 13, 2010; accepted May 18, 2010.
- Parkinson’s disease;
- regulatory T cells;
- therapeutic vaccination
J. Neurochem. (2010) 114, 1261–1276.
Neurodegenerative diseases, notably Alzheimer’s and Parkinson’s diseases, are amongst the most devastating disorders afflicting the elderly. Currently, no curative treatments or treatments that interdict disease progression exist. Over the past decade, immunization strategies have been proposed to combat disease progression. Such strategies induce humoral immune responses against misfolded protein aggregates to facilitate their clearance. Robust adaptive immunity against misfolded proteins, however, accelerates disease progression, precipitated by induced effector T cell responses that lead to encephalitis and neuronal death. Since then, mechanisms that attenuate such adaptive neurotoxic immune responses have been sought. We propose that shifting the balance between effector and regulatory T cell activity can attenuate neurotoxic inflammatory events. This review summarizes advances in immune regulation to achieve a homeostatic glial response for therapeutic gain. Promising new ways to optimize immunization schemes and measure their clinical efficacy are also discussed.