Bex1 is involved in the regeneration of axons after injury
Article first published online: 28 SEP 2010
© 2010 The Authors. Journal of Neurochemistry © 2010 International Society for Neurochemistry
Journal of Neurochemistry
Special Issue: Introducing Preclinical Systematic Reviews
Volume 115, Issue 4, pages 910–920, November 2010
How to Cite
Khazaei, M. R., Halfter, H., Karimzadeh, F., Koo, J. H., Margolis, F. L. and Young, P. (2010), Bex1 is involved in the regeneration of axons after injury. Journal of Neurochemistry, 115: 910–920. doi: 10.1111/j.1471-4159.2010.06960.x
- Issue published online: 21 OCT 2010
- Article first published online: 28 SEP 2010
- Accepted manuscript online: 21 AUG 2010 07:07AM EST
- Received April 13, 2010; revised manuscript received August 3, 2010; accepted August 9, 2010.
- axon injury;
J. Neurochem. (2010) 115, 910–920.
Successful axonal regeneration is a complex process determined by both axonal environment and endogenous neural capability of the regenerating axons in the central and the peripheral nervous systems. Numerous external inhibitory factors inhibit axonal regeneration after injury. In response, neurons express various regeneration-associated genes to overcome this inhibition and increase the intrinsic growth capacity. In the present study, we show that the brain-expressed X-linked (Bex1) protein was over-expressed as a result of peripheral axonal damage. Bex1 antagonized the axon outgrowth inhibitory effect of myelin-associated glycoprotein. The involvement of Bex1 in axon regeneration was further confirmed in vivo. We have demonstrated that Bex1 knock-out mice showed lower capability for regeneration after peripheral nerve injury than wild-type animals. Wild-type mice could recover from sciatic nerve injury much faster than Bex1 knock-out mice. Our findings suggest that Bex1 could be considered as regeneration-associated gene.