Appendix S1. Supplementary Methods.

Fig. S1. Size alterations of GC-A and GC-B in brain regions.

Fig. S2. RT-PCR analyses of GC-A and GC-B expression in brain.

Fig. S3. GC-A and GC-B expression in P2 brain from males and females and an examination of potential effects of phosphatase inhibition (+ OA) during tissue homogenization.

Fig. S4. Developmental regulation of GC-A expression in liver and kidney.

Fig. S5. Affinity-labeling of IGF-II/Man-6-P receptors.

Fig. S6. Comparative analyses of GC-A and NEP deglycosylation.

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