CREB: a multifaceted regulator of neuronal plasticity and protection
Article first published online: 2 DEC 2010
© 2010 The Authors. Journal of Neurochemistry © 2010 International Society for Neurochemistry
Journal of Neurochemistry
Volume 116, Issue 1, pages 1–9, January 2011
How to Cite
Sakamoto, K., Karelina, K. and Obrietan, K. (2011), CREB: a multifaceted regulator of neuronal plasticity and protection. Journal of Neurochemistry, 116: 1–9. doi: 10.1111/j.1471-4159.2010.07080.x
- Issue published online: 7 DEC 2010
- Article first published online: 2 DEC 2010
- Accepted manuscript online: 29 OCT 2010 11:15AM EST
- Received August 16, 2010; revised manuscript received October 19, 2010; accepted October 20, 2010.
- cell death;
J. Neurochem. (2011) 116, 1–9.
Since its initial characterization over 20 years ago, there has been intense and unwavering interest in understanding the role of the transcription factor cAMP-responsive element binding protein (CREB) in nervous system physiology. Through an array of experimental approaches and model systems, researchers have begun to unravel the complex and multifaceted role of this transcription factor in such diverse processes as neurodevelopment, synaptic plasticity, and neuroprotection. Here we discuss current insights into the molecular mechanisms by which CREB couples synaptic activity to long-term changes in neuronal plasticity, which is thought to underlie learning and memory. We also discuss work showing that CREB is a critical component of the neuroprotective transcriptional network, and data indicating that CREB dysregulation contributes to an array of neuropathological conditions.