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Protein kinase C activity regulates d-serine availability in the brain

  1. Charles Vargas-Lopes1,
  2. Caroline Madeira1,
  3. Suzana A. Kahn1,
  4. Ingrid Albino do Couto1,
  5. Patricia Bado1,
  6. Jean Christophe Houzel1,
  7. Joari De Miranda2,
  8. Marta S. de Freitas3,
  9. Sergio T. Ferreira4,
  10. Rogerio Panizzutti1

Article first published online: 16 DEC 2010

DOI: 10.1111/j.1471-4159.2010.07102.x

Issue

Journal of Neurochemistry

Journal of Neurochemistry

Volume 116, Issue 2, pages 281–290, January 2011

Additional Information

How to Cite

Vargas-Lopes, C., Madeira, C., Kahn, S. A., Albino do Couto, I., Bado, P., Houzel, J. C., De Miranda, J., de Freitas, M. S., Ferreira, S. T. and Panizzutti, R. (2011), Protein kinase C activity regulates d-serine availability in the brain. Journal of Neurochemistry, 116: 281–290. doi: 10.1111/j.1471-4159.2010.07102.x

Author Information

  1. 1

    Laboratório de Fronteiras em Neurociências, Instituto de Ciências Biomédicas, Universidade Federal do Rio de Janeiro, Rio de Janeiro, RJ, Brazil

  2. 2

    Center for Infection and Immunity, Mailman School of Public Health, Columbia University, New York, NY, USA

  3. 3

    Departamento de Farmacologia, Instituto de Biologia, Universidade do Estado do Rio de Janeiro, Rio de Janeiro, RJ, Brazil

  4. 4

    Laboratório de Doenças Neurodegenerativas, Instituto de Bioquímica Médica, Universidade Federal do Rio de Janeiro, Rio de Janeiro, RJ, Brazil

*Address correspondence and reprint requests to Rogerio Panizzutti, Instituto de Ciências Biomédicas, CCS, sala F1-03, Universidade Federal do Rio de Janeiro, Rio de Janeiro, RJ 21941-590, Brazil. E-mail: rogerio@anato.ufrj.br

Publication History

  1. Issue published online: 16 DEC 2010
  2. Article first published online: 16 DEC 2010
  3. Accepted manuscript online: 10 NOV 2010 12:53PM EST
  4. Received July 20, 2010; revised manuscript received October 12, 2010; accepted October 29, 2010.

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Figure S1. PKC activity does not affect extracellular glutamate levels in astrocytes and neurons.

Figure S2. Performance of the experimental animals in object recognition task.

Figure S3. Consensus sequences for PKC phosphorylation in mammalian SR.

Table S1. PKC activity specifically modulates d-serine levels in the rat frontal cortex.

Table S2. Object recognition task regulates d-serine levels in cortex and hippocampus.

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