In this Issue
Article first published online: 10 JUN 2011
Journal of Neurochemistry © 2011 International Society for Neurochemistry
Journal of Neurochemistry
Volume 118, Issue 1, page i, July 2011
How to Cite
(2011), In this Issue. Journal of Neurochemistry, 118: i. doi: 10.1111/j.1471-4159.2011.07340.x
- Issue published online: 10 JUN 2011
- Article first published online: 10 JUN 2011
Expression of human equilibrative nucleoside transporter 1 in mouse neurons regulates adenosine levels in physiological and hypoxic-ischemic conditions
Under stressful conditions, extracellular levels of nucleosides ATP and adenosine are exacerbated. It was believed that this resulted from its increased intracellular accumulation and subsequent release through equilibrative nucleoside transporters (ENTs). Here, by the use of transgenic mice overexpressing subtype ENT1 in neurons but not in astrocytes, evidence is provided that nucleoside transporters into neurons likely contribute to the removal of adenosine from the synaptic space even during a hypoxic or ischemic insult.
Glycogen synthase kinase 3β in the basolateral amygdala is critical for the reconsolidation of cocaine reward memory
Exposure to cocaine-associated conditioned stimuli elicits craving and increases the probability of cocaine relapse in cocaine users even after extended periods of abstinence. Inhibition of GSK-3βactivity in the basolateral amygdale (BLA) following exposure to previously drug paired chambers disrupts the reconsolidation of cocaine reward memory. The presented results indicate that GSK-3β activity in the BLA mediates the reconsolidation of cocaine cue memories.
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