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  • Albaugh V. L., Vary T. C., Ilkayeva O. et al. (2010) Atypical antipsychotics rapidly and inappropriately switch peripheral fuel utilization to lipids, impairing metabolic flexibility in rodents. Schizophr. Bull. Published Online doi: 10.1093/schbul/sbq053.
  • Albaugh V. L., Judson J. G., She P., Lang C. H., Maresca K. P., Joyal J. L. and Lynch C. J. (2011) Olanzapine promotes fat accumulation in male rats by decreasing physical activity, repartitioning energy and increasing adipose tissue lipogenesis while impairing lipolysis. Mol Psychiatry 16, 569581.
  • Aravagiri M., Teper Y. and Marder S. R. (1999) Pharmacokinetics and tissue distribution of olanzapine in rats. Biopharm. Drug Dispos. 20, 369377.
  • Attarbaschi T., Sacher J., Geiss-Granadia T. et al. (2007) Striatal D(2) receptor occupancy in bipolar patients treated with olanzapine. Eur. Neuropsychopharmacol. 17, 102107.
  • Bazan N. G. (2005) Lipid signaling in neural plasticity, brain repair, and neuroprotection. Mol. Neurobiol. 32, 89103.
  • Bazinet R. P., Lee H. J., Felder C. C., Porter A. C., Rapoport S. I. and Rosenberger T. A. (2005) Rapid high-energy microwave fixation is required to determine the anandamide (N-arachidonoylethanolamine) concentration of rat brain. Neurochem. Res. 30, 597601.
  • Bazinet R. P., Rao J. S., Chang L., Rapoport S. I. and Lee H. J. (2006) Chronic carbamazepine decreases the incorporation rate and turnover of arachidonic acid but not docosahexaenoic acid in brain phospholipids of the unanesthetized rat: relevance to bipolar disorder. Biol. Psychiatry 59, 401407.
  • Belmaker R. H. (2004) Bipolar disorder. N. Engl. J. Med. 351, 476486.
  • Berg K. A., Maayani S., Goldfarb J., Scaramellini C., Leff P. and Clarke W. P. (1998) Effector pathway-dependent relative efficacy at serotonin type 2A and 2C receptors: evidence for agonist-directed trafficking of receptor stimulus. Mol. Pharmacol. 54, 94104.
  • Bezard J., Blond J. P., Bernard A. and Clouet P. (1994) The metabolism and availability of essential fatty acids in animal and human tissues. Reprod. Nutr. Dev. 34, 539568.
  • Bhattacharjee A. K., Meister L. M., Chang L., Bazinet R. P., White L. and Rapoport S. I. (2007) In vivo imaging of disturbed pre- and post-synaptic dopaminergic signaling via arachidonic acid in a rat model of Parkinson’s disease. Neuroimage 37, 11121121.
  • Bostwick J. M. and Pankratz V. S. (2000) Affective disorders and suicide risk: a reexamination. Am. J. Psychiatry 157, 19251932.
  • Bymaster F. P., Calligaro D. O., Falcone J. F., Marsh R. D., Moore N. A., Tye N. C., Seeman P. and Wong D. T. (1996) Radioreceptor binding profile of the atypical antipsychotic olanzapine. Neuropsychopharmacology 14, 8796.
  • Calabrese J. R., Kimmel S. E., Woyshville M. J., Rapport D. J., Faust C. J., Thompson P. A. and Meltzer H. Y. (1996) Clozapine for treatment-refractory mania. Am. J. Psychiatry 153, 759764.
  • Chang M. C., Grange E., Rabin O., Bell J. M., Allen D. D. and Rapoport S. I. (1996) Lithium decreases turnover of arachidonate in several brain phospholipids. Neurosci. Lett. 220, 171174.
  • Chang M. C., Arai T., Freed L. M. et al. (1997) Brain incorporation of [1-11C]arachidonate in normocapnic and hypercapnic monkeys, measured with positron emission tomography. Brain Res. 755, 7483.
  • Chang M. C., Contreras M. A., Rosenberger T. A., Rintala J. J., Bell J. M. and Rapoport S. I. (2001) Chronic valproate treatment decreases the in vivo turnover of arachidonic acid in brain phospholipids: a possible common effect of mood stabilizers. J. Neurochem. 77, 796803.
  • Cunnane S. C., Ryan M. A., Nadeau C. R., Bazinet R. P., Musa-Veloso K. and McCloy U. (2003) Why is carbon from some polyunsaturates extensively recycled into lipid synthesis? Lipids 38, 477484.
  • DeGeorge J. J., Noronha J. G., Bell J., Robinson P. and Rapoport S. I. (1989) Intravenous injection of [1-14C]arachidonate to examine regional brain lipid metabolism in unanesthetized rats. J. Neurosci. Res. 24, 413423.
  • DeGeorge J. J., Nariai T., Yamazaki S., Williams W. M. and Rapoport S. I. (1991) Arecoline-stimulated brain incorporation of intravenously administered fatty acids in unanesthetized rats. J. Neurochem. 56, 352355.
  • DeMar J. C., Jr, Ma K., Bell J. M. and Rapoport S. I. (2004) Half-lives of docosahexaenoic acid in rat brain phospholipids are prolonged by 15 weeks of nutritional deprivation of n-3 polyunsaturated fatty acids. J. Neurochem. 91, 11251137.
  • Demar J. C., Jr, Ma K., Chang L., Bell J. M. and Rapoport S. I. (2005) alpha-Linolenic acid does not contribute appreciably to docosahexaenoic acid within brain phospholipids of adult rats fed a diet enriched in docosahexaenoic acid. J. Neurochem. 94, 10631076.
  • DeMar J. C. ., Jr, Lee H. J., Ma K., Chang L., Bell J. M., Rapoport S. I. and Bazinet R. P. (2006) Brain elongation of linoleic acid is a negligible source of the arachidonate in brain phospholipids of adult rats. Biochim. Biophys. Acta 1761, 10501059.
  • Dennis E. A. (1994) Diversity of group types, regulation, and function of phospholipase A2. J. Biol. Chem. 269, 1305713060.
  • Deutsch J., Grange E., Rapoport S. I. and Purdon A. D. (1994) Isolation and quantitation of long-chain acyl-coenzyme A esters in brain tissue by solid-phase extraction. Anal. Biochem. 220, 321323.
  • Deutsch J., Rapoport S. I. and Purdon A. D. (1997) Relation between free fatty acid and acyl-CoA concentrations in rat brain following decapitation. Neurochem. Res. 22, 759765.
  • Ferno J., Vik-Mo A. O., Jassim G. et al. (2009) Acute clozapine exposure in vivo induces lipid accumulation and marked sequential changes in the expression of SREBP, PPAR, and LXR target genes in rat liver. Psychopharmacology (Berl) 203, 7384.
  • Fitzpatrick F. A. and Soberman R. (2001) Regulated formation of eicosanoids. J. Clin. Invest. 107, 13471351.
  • Folch J., Lees M. and Sloane Stanley G. H. (1957) A simple method for the isolation and purification of total lipides from animal tissues. J. Biol. Chem. 226, 497509.
  • Frangou S., Lewis M. and McCrone P. (2006) Efficacy of ethyl-eicosapentaenoic acid in bipolar depression: randomised double-blind placebo-controlled study. Br. J. Psychiatry 188, 4650.
  • Gao F., Kiesewetter D., Chang L., Rapoport S. I. and Igarashi M. (2010) Quantifying conversion of linoleic to arachidonic and other n-6 polyunsaturated fatty acids in unanesthetized rats. J. Lipid Res. 51, 29402946.
  • Ghelardoni S., Tomita Y. A., Bell J. M., Rapoport S. I. and Bosetti F. (2004) Chronic carbamazepine selectively downregulates cytosolic phospholipase A2 expression and cyclooxygenase activity in rat brain. Biol. Psychiatry 56, 248254.
  • Holman R. T. (1986) Control of polyunsaturated acids in tissue lipids. J. Am. Coll. Nutr. 5, 183211.
  • Igarashi M., Gao F., Kim H. W., Ma K., Bell J. M. and Rapoport S. I. (2009) Dietary n-6 PUFA deprivation for 15 weeks reduces arachidonic acid concentrations while increasing n-3 PUFA concentrations in organs of post-weaning male rats. Biochim. Biophys. Acta 1791, 132139.
  • Igarashi M., Ma K., Gao F., Kim H. W., Greenstein D., Rapoport S. I. and Rao J. S. (2010) Brain lipid concentrations in bipolar disorder. J. Psychiatr. Res. 44, 177182.
  • Kaddurah-Daouk R., McEvoy J., Baillie R. A., Lee D., Yao J. K., Doraiswamy P. M. and Krishnan K. R. (2007) Metabolomic mapping of atypical antipsychotic effects in schizophrenia. Mol. Psychiatry 12, 934945.
  • Kapur S. and Remington G. (2001) Atypical antipsychotics: new directions and new challenges in the treatment of schizophrenia. Annu. Rev. Med. 52, 503517.
  • Kessler R. C., Merikangas K. R. and Wang P. S. (2007) Prevalence, comorbidity, and service utilization for mood disorders in the United States at the beginning of the twenty-first century. Annu. Rev. Clin. Psychol. 3, 137158.
  • Kim H. W., Rapoport S. I. and Rao J. S. (2011a) Altered arachidonic acid cascade enzymes in postmortem brain from bipolar disorder patients. Mol. Psychiatry 16, 419428.
  • Kim H. W., Rao J. S., Rapoport S. I. and Igarashi M. (2011b) Dietary n-6 PUFA deprivation downregulates arachidonate but upregulates docosahexaenoate metabolizing enzymes in rat brain. Biochim. Biophys. Acta 1811, 111117.
  • Lalovic A., Levy E., Canetti L., Sequeira A., Montoudis A. and Turecki G. (2007) Fatty acid composition in postmortem brains of people who completed suicide. J. Psychiatry Neurosci. 32, 363370.
  • Lee H. J., Ghelardoni S., Chang L., Bosetti F., Rapoport S. I. and Bazinet R. P. (2005) Topiramate does not alter the kinetics of arachidonic or docosahexaenoic acid in brain phospholipids of the unanesthetized rat. Neurochem. Res. 30, 677683.
  • Lee H. J., Rao J. S., Ertley R. N., Chang L., Rapoport S. I. and Bazinet R. P. (2007a) Chronic fluoxetine increases cytosolic phospholipase A(2) activity and arachidonic acid turnover in brain phospholipids of the unanesthetized rat. Psychopharmacology (Berl) 190, 103115.
  • Lee H. J., Rao J. S., Rapoport S. I. and Bazinet R. P. (2007b) Antimanic therapies target brain arachidonic acid signaling: lessons learned about the regulation of brain fatty acid metabolism. Prostaglandins Leukot. Essent. Fatty Acids 77, 239246.
  • Lee H. J., Rao J. S., Chang L., Rapoport S. I. and Bazinet R. P. (2008) Chronic N-methyl-d-aspartate administration increases the turnover of arachidonic acid within brain phospholipids of the unanesthetized rat. J. Lipid Res. 49, 162168.
  • Lee H. J., Rao J. S., Chang L., Rapoport S. I. and Kim H. W. (2010) Chronic imipramine but not bupropion increases arachidonic acid signaling in rat brain: is this related to ‘switching’ in bipolar disorder? Mol. Psychiatry 15, 602614.
  • Livak K. J. and Schmittgen T. D. (2001) Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. Methods 25, 402408.
  • Lucas K. K. and Dennis E. A. (2005) Distinguishing phospholipase A2 types in biological samples by employing group-specific assays in the presence of inhibitors. Prostaglandins Other Lipid Mediat. 77, 235248.
  • Makrides M., Neumann M. A., Byard R. W., Simmer K. and Gibson R. A. (1994) Fatty acid composition of brain, retina, and erythrocytes in breast- and formula-fed infants. Am. J. Clin. Nutr. 60, 189194.
  • McNamara R. K., Jandacek R., Rider T., Tso P., Stanford K. E., Hahn C. G. and Richtand N. M. (2008) Deficits in docosahexaenoic acid and associated elevations in the metabolism of arachidonic acid and saturated fatty acids in the postmortem orbitofrontal cortex of patients with bipolar disorder. Psychiatry Res. 160, 285299.
  • McNamara R. K., Jandacek R., Rider T., Tso P., Cole-Strauss A. and Lipton J. W. (2011a) Atypical antipsychotic medications increase postprandial triglyceride and glucose levels in male rats: relationship with stearoyl-CoA desaturase activity. Schizophr. Res. 129, 6673.
  • McNamara R. K., Jandacek R., Rider T., Tso P., Cole-Strauss A. and Lipton J. W. (2011b) Differential effects of antipsychotic medications on polyunsaturated fatty acid biosynthesis in rats: Relationship with liver delta6-desaturase expression. Schizophr. Res. 129, 5765.
  • Minet-Ringuet J., Even P. C., Valet P. et al. (2007) Alterations of lipid metabolism and gene expression in rat adipocytes during chronic olanzapine treatment. Mol. Psychiatry 12, 562571.
  • Noaghiul S. and Hibbeln J. R. (2003) Cross-national comparisons of seafood consumption and rates of bipolar disorders. Am. J. Psychiatry 160, 22222227.
  • Oruch R., Pryme I. F. and Holmsen H. (2008) Effects of psychotropic drugs on the thrombin-induced liberation of arachidonate in human platelets. Saudi Med. J. 29, 13971407.
  • Pramyothin P. and Khaodhiar L. (2010) Metabolic syndrome with the atypical antipsychotics. Curr. Opin. Endocrinol. Diabetes Obes. 17, 460466.
  • Purdon D., Arai T. and Rapoport S. (1997) No evidence for direct incorporation of esterified palmitic acid from plasma into brain lipids of awake adult rat. J. Lipid Res. 38, 526530.
  • Qu Y., Chang L., Klaff J., Balbo A. and Rapoport S. I. (2003) Imaging brain phospholipase A2 activation in awake rats in response to the 5-HT2A/2C agonist (+/-)2,5-dimethoxy-4-iodophenyl-2-aminopropane (DOI). Neuropsychopharmacology 28, 244252.
  • Radin N. S. (1981) Extraction of tissue lipids with a solvent of low toxicity. Methods Enzymol. 72, 57.
  • Rao J. S., Ertley R. N., DeMar J. C.. Jr, Rapoport S. I., Bazinet R. P. and Lee H. J. (2007a) Dietary n-3 PUFA deprivation alters expression of enzymes of the arachidonic and docosahexaenoic acid cascades in rat frontal cortex. Mol. Psychiatry 12, 151157.
  • Rao J. S., Ertley R. N., Rapoport S. I., Bazinet R. P. and Lee H. J. (2007b) Chronic NMDA administration to rats up-regulates frontal cortex cytosolic phospholipase A2 and its transcription factor, activator protein-2. J. Neurochem. 102, 19181927.
  • Rao J. S., Lee H. J., Rapoport S. I. and Bazinet R. P. (2008) Mode of action of mood stabilizers: is the arachidonic acid cascade a common target? Mol. Psychiatry 13, 585596.
  • Rao J. S., Harry G. J., Rapoport S. I. and Kim H. W. (2010) Increased excitotoxicity and neuroinflammatory markers in postmortem frontal cortex from bipolar disorder patients. Mol. Psychiatry 15, 384392.
  • Rapoport S. I. (2008) Arachidonic acid and the brain. J. Nutr. 138, 25152520.
  • Rapoport S. I. and Bosetti F. (2002) Do lithium and anticonvulsants target the brain arachidonic acid cascade in bipolar disorder? Arch. Gen. Psychiatry 59, 592596.
  • Rapoport S. I., Chang M. C. and Spector A. A. (2001) Delivery and turnover of plasma-derived essential PUFAs in mammalian brain. J. Lipid Res. 42, 678685.
  • Rapoport S. I., Rao J. S. and Igarashi M. (2007) Brain metabolism of nutritionally essential polyunsaturated fatty acids depends on both the diet and the liver. Prostaglandins Leukot. Essent. Fatty Acids 77, 251261.
  • Rapoport S. I., Basselin M., Kim H. W. and Rao J. S. (2009) Bipolar disorder and mechanisms of action of mood stabilizers. Brain Res. Rev. 61, 185209.
  • Rintala J., Seemann R., Chandrasekaran K., Rosenberger T. A., Chang L., Contreras M. A., Rapoport S. I. and Chang M. C. (1999) 85 kDa cytosolic phospholipase A2 is a target for chronic lithium in rat brain. Neuroreport 10, 38873890.
  • Robinson P. J., Noronha J., DeGeorge J. J., Freed L. M., Nariai T. and Rapoport S. I. (1992) A quantitative method for measuring regional in vivo fatty-acid incorporation into and turnover within brain phospholipids: review and critical analysis. Brain Res. Brain Res. Rev. 17, 187214.
  • Samuelsson B., Dahlen S. E., Lindgren J. A., Rouzer C. A. and Serhan C. N. (1987) Leukotrienes and lipoxins: structures, biosynthesis, and biological effects. Science 237, 11711176.
  • Scherk H., Pajonk F. G. and Leucht S. (2007) Second-generation antipsychotic agents in the treatment of acute mania: a systematic review and meta-analysis of randomized controlled trials. Arch. Gen. Psychiatry 64, 442455.
  • Shimshoni J. A., Basselin M., Li L. O., Coleman R. A., Rapoport S. I. and Modi H. R. (2011) Valproate uncompetitively inhibits arachidonic acid acylation by rat acyl-CoA synthetase 4: Relevance to valproate’s efficacy against bipolar disorder. Biochim. Biophys. Acta 1811, 163169.
  • Skipski V. P., Barclay M., Reichman E. S. and Good J. J. (1967) Separation of acidic phospholipids by one-dimensional thin-layer chromatography. Biochim. Biophys. Acta 137, 8089.
  • Skipski V. P., Good J. J., Barclay M. and Reggio R. B. (1968) Quantitative analysis of simple lipid classes by thin-layer chromatography. Biochim. Biophys. Acta 152, 1019.
  • Song C. and Nerdal W. (2008) Olanzapine interaction with dipalmitoyl phosphatidylcholine (DPPC) and 1-palmitoyl-2-oleoyl phosphatidylserine (POPS) bilayer: a (13)C and (31)P solid-state NMR study. Biophys. Chem. 134, 4755.
  • Spector A. A. (2009) Arachidonic acid cytochrome P450 epoxygenase pathway. J. Lipid Res. 50 Suppl, S52S56.
  • Steinkopf S., Schelderup A. K., Gjerde H. L., Pfeiffer J., Thoresen S., Gjerde A. U. and Holmsen H. (2008) The psychotropic drug olanzapine (Zyprexa) increases the area of acid glycerophospholipid monolayers. Biophys. Chem. 134, 3946.
  • Stoll A. L., Severus W. E., Freeman M. P., Rueter S., Zboyan H. A., Diamond E., Cress K. K. and Marangell L. B. (1999) Omega 3 fatty acids in bipolar disorder: a preliminary double-blind, placebo-controlled trial. Arch. Gen. Psychiatry 56, 407412.
  • Svennerholm L., Bostrom K. and Jungbjer B. (1997) Changes in weight and compositions of major membrane components of human brain during the span of adult human life of Swedes. Acta Neuropathol. 94, 345352.
  • Vial D. and Piomelli D. (1995) Dopamine D2 receptors potentiate arachidonate release via activation of cytosolic, arachidonate-specific phospholipase A2. J. Neurochem. 64, 27652772.
  • Vidarsdottir S., de Leeuw van Weenen J. E., Frolich M., Roelfsema F., Romijn J. A. and Pijl H. (2010) Effects of olanzapine and haloperidol on the metabolic status of healthy men. J. Clin. Endocrinol. Metab. 95, 118125.
  • Washizaki K., Smith Q. R., Rapoport S. I. and Purdon A. D. (1994) Brain arachidonic acid incorporation and precursor pool specific activity during intravenous infusion of unesterified [3H]arachidonate in the anesthetized rat. J. Neurochem. 63, 727736.
  • Waugh R. J., Morrow J. D., Roberts 2nd L. J. and Murphy R. C. (1997) Identification and relative quantitation of F2-isoprostane regioisomers formed in vivo in the rat. Free Radic. Biol. Med., 23, 943954.
  • Weerasinghe G. R., Rapoport S. I. and Bosetti F. (2004) The effect of chronic lithium on arachidonic acid release and metabolism in rat brain does not involve secretory phospholipase A2 or lipoxygenase/cytochrome P450 pathways. Brain Res. Bull. 63, 485489.
  • Yang H. C., Mosior M., Johnson C. A., Chen Y. and Dennis E. A. (1999) Group-specific assays that distinguish between the four major types of mammalian phospholipase A2. Anal. Biochem. 269, 278288.