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Table S1. The functional classification of the proteins (as described in Collins et al. 2006) found in hippocampal post synaptic density proteome. Shaded rows distinguish those proteins that were quantified based on criteria described in Materials and Methods.

Table S2. Protein data from lithium-treated versus controls; comparisons of summed peptide intensities with effect sizes. Effect sizes (Cohen’s d) were calculated using 2t/√dferror, where 0.8 is considered a large effect, 0.5 moderate, and 0.2 small. Proteins are sorted from largest to smallest effect size using absolute values. Positive effect sizes indicate higher levels on lithium. The p value shown in table is calculated by two tailed T- test as described in protein quantification and statistical analyses section of Materials and Methods.

Table S3. Protein data from valproate-treated versus controls; comparisons of summed peptide intensities with effect sizes. Effect sizes (Cohen’s d) were calculated using 2t/√dferror, where 0.8 is considered a large effect, 0.5 moderate, and 0.2 small. Proteins are sorted from largest to smallest effect size using absolute values. Positive effect sizes indicate higher levels on valproate. The p value shown in table is calculated by two tailed T- test as described in protein quantification and statistical analyses section of Materials and Methods.

Table S4. The top five non-canonical networks of proteins identified by Ingenuity Pathway Analysis.

Table S5. Concentration (log2-fold) changes of major scaffolding proteins of post synaptic density protein complex purified from hippocampus of lithium and valproate treated rats.

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