Cross-talk between human mesenchymal stem/progenitor cells (MSCs) and rat hippocampal slices in LPS-stimulated cocultures: the MSCs are activated to secrete prostaglandin E2
Article first published online: 1 NOV 2011
© 2011 The Authors. Journal of Neurochemistry © 2011 International Society for Neurochemistry
Journal of Neurochemistry
Volume 119, Issue 5, pages 1052–1063, December 2011
How to Cite
Foraker, J. E., Oh, J. Y., Ylostalo, J. H., Lee, R. H., Watanabe, J. and Prockop, D. J. (2011), Cross-talk between human mesenchymal stem/progenitor cells (MSCs) and rat hippocampal slices in LPS-stimulated cocultures: the MSCs are activated to secrete prostaglandin E2. Journal of Neurochemistry, 119: 1052–1063. doi: 10.1111/j.1471-4159.2011.07511.x
- Issue published online: 14 NOV 2011
- Article first published online: 1 NOV 2011
- Accepted manuscript online: 29 SEP 2011 02:26AM EST
- Received July 28, 2011; revised manuscript received September 22, 2011; accepted September 26, 2011.
J. Neurochem. (2011) 119, 1052–1063.
Mesenchymal stem/progenitor cells (MSCs) improve functional outcome in a number of disease models through suppression of inflammation. However, their effects on neuroinflammation are unknown. In this study, we show that MSCs suppress endotoxin-induced glial activation in organotypic hippocampal slice cultures (OHSCs). Lipopolysaccharide-stimulated OHSCs activated MSCs to increase the expression of cyclo-oxygenase-2 and produce prostaglandin E2. MSC-derived prostaglandin E2, then suppressed pro-inflammatory cytokine production by the OHSCs. Together, the results suggest the potential anti-inflammatory mechanism of MSCs in models of disease and support earlier observations that MSCs may offer a therapy for neuroinflammation produced by trauma or disease.