Quetiapine prevents oligodendrocyte and myelin loss and promotes maturation of oligodendrocyte progenitors in the hippocampus of global cerebral ischemia mice


Address correspondence and reprint requests to Xin-Min Li, Department of Psychiatry, University of Manitoba, PZ432-771, Bannatyne Ave., Winnipeg, MB, Canada R3E 3N4. E-mail: xinmin_li@umanitoba.ca (or) Qingrong Tan, Department of Psychiatry, Xijing Hospital, Fourth Military Medical University, 15 West Changle Road, Xi’an, Shanxi Province, China 710032. E-mail: tanqingr@fmmu.edu.cn


White matter impairment is a feature of vascular depression. The anti-psychotic quetiapine has been shown to enhance the therapeutic effects of anti-depressants on vascular depression, but the mechanism remains unknown. In this study, we found that 2 weeks of treatment with quetiapine prior to bilateral carotid artery occlusion and reperfusion, in an animal model of vascular depression, resulted in reduced myelin breakdown and oligodendrocyte loss compared to placebo-treated mice on post-operative day (POD) 7. For late stage of recovery (POD40), quetiapine treatment resulted in enhanced oligodendrocyte maturation relative to placebo. The results suggest that quetiapine is a potential intervention for oligodendrocyte damage and this may contribute to its anti-depressant effects through white matter protection in vascular depression.