These authors contributed equally to this work.
Quetiapine prevents oligodendrocyte and myelin loss and promotes maturation of oligodendrocyte progenitors in the hippocampus of global cerebral ischemia mice
Article first published online: 14 AUG 2012
© 2012 The Authors. Journal of Neurochemistry © 2012 International Society for Neurochemistry
Journal of Neurochemistry
Volume 123, Issue 1, pages 14–20, October 2012
How to Cite
Bi, X., Zhang, Y., Yan, B., Fang, S., He, J., Zhang, D., Zhang, Z., Kong, J., Tan, Q. and Li, X.-M. (2012), Quetiapine prevents oligodendrocyte and myelin loss and promotes maturation of oligodendrocyte progenitors in the hippocampus of global cerebral ischemia mice. Journal of Neurochemistry, 123: 14–20. doi: 10.1111/j.1471-4159.2012.07883.x
- Issue published online: 10 SEP 2012
- Article first published online: 14 AUG 2012
- Accepted manuscript online: 20 JUL 2012 12:04PM EST
- Received March 8, 2012; revised manuscript received July 14, 2012; accepted July 18, 2012.
- cerebral ischemia;
- vascular depression
White matter impairment is a feature of vascular depression. The anti-psychotic quetiapine has been shown to enhance the therapeutic effects of anti-depressants on vascular depression, but the mechanism remains unknown. In this study, we found that 2 weeks of treatment with quetiapine prior to bilateral carotid artery occlusion and reperfusion, in an animal model of vascular depression, resulted in reduced myelin breakdown and oligodendrocyte loss compared to placebo-treated mice on post-operative day (POD) 7. For late stage of recovery (POD40), quetiapine treatment resulted in enhanced oligodendrocyte maturation relative to placebo. The results suggest that quetiapine is a potential intervention for oligodendrocyte damage and this may contribute to its anti-depressant effects through white matter protection in vascular depression.