Citicoline in pre-clinical animal models of stroke: a meta-analysis shows the optimal neuroprotective profile and the missing steps for jumping into a stroke clinical trial
Article first published online: 23 AUG 2012
© 2012 The Authors Journal of Neurochemistry © 2012 International Society for Neurochemistry
Journal of Neurochemistry
Volume 123, Issue 2, pages 217–225, October 2012
How to Cite
J. Neurochem. (2012) 123, 217–225.
- Issue published online: 1 OCT 2012
- Article first published online: 23 AUG 2012
- Accepted manuscript online: 28 JUL 2012 09:45AM EST
- Manuscript Accepted: 24 JUL 2012
- Manuscript Revised: 23 JUL 2012
- Manuscript Received: 21 MAY 2012
- Neurovascular Research Laboratory
- Spanish stroke research. Grant Numbers: RENEVAS, RD06/0026/0010
- European Stroke Network. Grant Numbers: EUSTROKE 7FP Health F2-08-202213, PI080481, EC07/90195, CP09/00265, FI 10/00508
- Carlos III Health Institute
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|jnc7891-sup-0001-FigureS1.tif||image/tif||11887K||Figure S1. Stratified analysis of citicoline effect on infarct volume reduction by permanent or temporary occlusion model [25.4% (17.6%, 33.3%) vs. 30.2% (15.3%, 45.1%)] (S1); low dose (<250 mg) vs. high dose (>250 mg) [27.4% (14.6%, 40.2% vs. 27.4% (18.2%, 36.6%)] and single vs. multiple doses [22.6% (14.1%, 31.1%) vs. 31.1% (18.2%, 36.6%); p<0.05]. Columns represent mean effect size in % and vertical lines represent standard error of mean (SEM).|
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