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jnc7911-sup-0001-FigureS1-S2-TableS1-S2.pdfapplication/PDF402K Table S1. Summary of CSF samples obtained from 4 different centres. Table S2. Summary of assay performance of the 3R- and 4R- tau iPCR assays. Figure S1. Development and optimisation of iPCR for 3R- and 4R- tau: Optimisation of RD3 (a) and RD4 (b) coating concentrations and sheep anti-tau DNA conjugate dilution factor for the 3R- (c) and the 4R- tau assays (d). Comparison of different artificial CSF ratio in sample dilution buffer in 3R-tau assay (e). Dilution series for 4R-tau in artificial CSF and sample dilution buffer, 4R-tau assays carried out in both sequential and combined incubations (f). Figure S2. CSF parallelism for 3R- (a) and 4R- tau (b) between buffer and CSFs; and the parallelism for 4R- tau (c) between artificial CSF and pooled clinical CSF.

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