Stroke outcome in the ketogenic state – a systematic review of the animal data


Address correspondence and reprint requests to Sean Murphy, Department of Neurological Surgery, Box 356470, University of Washington School of Medicine, Seattle, WA 98195, USA.


As a predictor of potential clinical outcome, we performed a systematic review of controlled studies that assessed experimental stroke outcome in rodents maintained on special diets (calorie restriction and ketogenic diet) or following the direct administration of ketone bodies. Pre-clinical studies were identified by searching web databases and the reference lists of relevant original articles and reviews. Sixteen published studies (a total of 733 experimental animals) met specific criteria and were analyzed using Cochrane Review Manager software. This resulted in objective evidence to suggest beneficial effects of the ketogenic pathway on pathological and functional outcomes following experimental stroke.