The studies described in this article examine retrospective reports of naturally occurring misperceptions of friendliness as sexual interest. Previous research has demonstrated that men perceive other people and situations more sexually than women do. The purpose of this research was to examine how this gender difference in perceptions of sexuality is exhibited in actual interactions between women and men. Two surveys of undergraduates were conducted. The results indicated that a large percentage of both women and men had experienced such misperceptions, although more women had than men. Most of these incidents were quickly resolved without problems; however, others involved some degree of forced sexual activity and left the individual feeling angry, humiliated, and depressed. Gender differences in the characteristics of these incidents and reactions to them are described. The implications of these findings for future research on gender differences in perceptions of sexual intent are discussed.