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Keywords:

  • antiviral activity;
  • Bignoniaceae;
  • EMCV;
  • HSV-1;
  • in vitro assays;
  • plant extracts;
  • VACV

Abstract

Aims:  To evaluate the antiviral activity of Bignoniaceae species occurring in the state of Minas Gerais, Brazil.

Methods and Results:  Ethanol extracts of different anatomical parts of bignoniaceous plant species have been evaluated in vitro against human herpesvirus type 1 (HSV-1), vaccinia virus (VACV) and murine encephalomyocarditis virus (EMCV) by the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay. A total of 34 extracts from 18 plant species selected according to ethnopharmacological and taxonomic criteria were screened. Fifteen of the 34 extracts (44·1%) have disclosed antiviral activity against one or more of the viruses assayed with EC50 values in the range of 23·2 ± 2·5–422·7 ± 10·9 μg ml−1.

Conclusions:  Twelve of the 34 extracts (35·3%) might be considered promising sources of antiviral natural products, as they have shown EC50 ≤ 100 μg ml−1. The present screening discloses the high potential of the Bignoniaceae family as source of antiviral agents.

Significance and Impact of the Study:  Active extracts were identified and deserve bioguided studies for the isolation of antiviral compounds and studies on mechanism of action.