Part of G. C. Brandão’s Doctorate Thesis at the Programa de Pós-Graduação em Ciências Farmacêuticas (PPGCF), Faculdade de Farmácia/UFMG, Belo Horizonte, MG, Brazil.
Antiviral activity of Bignoniaceae species occurring in the State of Minas Gerais (Brazil): part 1
Article first published online: 14 SEP 2010
© 2010 The Authors. Journal compilation © 2010 The Society for Applied Microbiology
Letters in Applied Microbiology
Volume 51, Issue 4, pages 469–476, October 2010
How to Cite
Brandão, G.C., Kroon, E.G., Dos Santos, J.R., Stehmann, J.R., Lombardi, J.A. and Braga de Oliveira, A. (2010), Antiviral activity of Bignoniaceae species occurring in the State of Minas Gerais (Brazil): part 1. Letters in Applied Microbiology, 51: 469–476. doi: 10.1111/j.1472-765X.2010.02924.x
- Issue published online: 14 SEP 2010
- Article first published online: 14 SEP 2010
- Accepted manuscript online: 20 AUG 2010 12:00AM EST
- 2010/0858: received 20 May 2010, revised 12 August 2010 and accepted 13 August 2010
- antiviral activity;
- in vitro assays;
- plant extracts;
Aims: To evaluate the antiviral activity of Bignoniaceae species occurring in the state of Minas Gerais, Brazil.
Methods and Results: Ethanol extracts of different anatomical parts of bignoniaceous plant species have been evaluated in vitro against human herpesvirus type 1 (HSV-1), vaccinia virus (VACV) and murine encephalomyocarditis virus (EMCV) by the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay. A total of 34 extracts from 18 plant species selected according to ethnopharmacological and taxonomic criteria were screened. Fifteen of the 34 extracts (44·1%) have disclosed antiviral activity against one or more of the viruses assayed with EC50 values in the range of 23·2 ± 2·5–422·7 ± 10·9 μg ml−1.
Conclusions: Twelve of the 34 extracts (35·3%) might be considered promising sources of antiviral natural products, as they have shown EC50 ≤ 100 μg ml−1. The present screening discloses the high potential of the Bignoniaceae family as source of antiviral agents.
Significance and Impact of the Study: Active extracts were identified and deserve bioguided studies for the isolation of antiviral compounds and studies on mechanism of action.