1472-8206/asset/olbannerleft.gif?v=1&s=5c0825c8c57cb987dbf83f37b85f9a7b97c62dbd)
1472-8206/asset/olbannerright.gif?v=1&s=525488a8904a98c0bd51a2645dea539f90502f02)
Citral inhibits cell proliferation and induces apoptosis and cell cycle arrest in MCF-7 cells
Article first published online: 28 JUL 2009
DOI: 10.1111/j.1472-8206.2009.00738.x
© 2009 The Authors Journal compilation © 2009 Société Française de Pharmacologie et de Thérapeutique
Additional Information
How to Cite
Chaouki, W., Leger, D. Y., Liagre, B., Beneytout, J.-L. and Hmamouchi, M. (2009), Citral inhibits cell proliferation and induces apoptosis and cell cycle arrest in MCF-7 cells. Fundamental & Clinical Pharmacology, 23: 549–556. doi: 10.1111/j.1472-8206.2009.00738.x
Publication History
- Issue published online: 4 SEP 2009
- Article first published online: 28 JUL 2009
- Received 22 May 2008; revised 29 March 2009; accepted 9 April 2009
- Abstract
- Article
- References
- Cited By
Keywords:
- anticancer;
- apoptosis;
- cell cycle;
- citral;
- inducible cyclo-oxgenase-2;
- MCF-7 cells
Abstract
Many natural components of plants extract are studied for their beneficial effects on health and particularly on carcinogenesis chemoprevention. In this study, we investigated the effect of citral (3,7-dimethyl-2,6-octadienal), a key component of essential oils extracted from several herbal plants, on the proliferation rate, cell cycle distribution, and apoptosis of the human breast cancer cell line MCF-7. The effects of this compound were also tested on cyclo-oxygenase activity. Citral treatment caused inhibition of MCF-7 cell growth (IC50-48 h: 18 × 10−5 m), with a cycle arrest in G2/M phase and apoptosis induction. Moreover, we observed a decrease in prostaglandin E2 synthesis 48 h after citral treatment. These findings suggest that citral has a potential chemopreventive effect.