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Keywords:

  • anticancer;
  • apoptosis;
  • cell cycle;
  • citral;
  • inducible cyclo-oxgenase-2;
  • MCF-7 cells

Abstract

Many natural components of plants extract are studied for their beneficial effects on health and particularly on carcinogenesis chemoprevention. In this study, we investigated the effect of citral (3,7-dimethyl-2,6-octadienal), a key component of essential oils extracted from several herbal plants, on the proliferation rate, cell cycle distribution, and apoptosis of the human breast cancer cell line MCF-7. The effects of this compound were also tested on cyclo-oxygenase activity. Citral treatment caused inhibition of MCF-7 cell growth (IC50-48 h: 18 × 10−5 m), with a cycle arrest in G2/M phase and apoptosis induction. Moreover, we observed a decrease in prostaglandin E2 synthesis 48 h after citral treatment. These findings suggest that citral has a potential chemopreventive effect.