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Short Communication
Short-term intravenous insulin infusion is associated with reduced expression of NADPH oxidase p47phox subunit in monocytes from type 2 diabetes patients
Article first published online: 10 JUL 2012
DOI: 10.1111/j.1472-8206.2012.01057.x
© 2012 The Authors Fundamental and Clinical Pharmacology © 2012 Société Française de Pharmacologie et de Thérapeutique
Issue
Fundamental & Clinical Pharmacology
Early View (Online Version of Record published before inclusion in an issue)
Additional Information
How to Cite
Vaquer, G., Magous, R., Cros, G., Wojtusciszyn, A., Renard, E., Chevassus, H., Petit, P., Lajoix, A.-D. and Oiry, C. (2012), Short-term intravenous insulin infusion is associated with reduced expression of NADPH oxidase p47phox subunit in monocytes from type 2 diabetes patients. Fundamental & Clinical Pharmacology. doi: 10.1111/j.1472-8206.2012.01057.x
Publication History
- Article first published online: 10 JUL 2012
- Accepted manuscript online: 14 JUN 2012 09:23AM EST
- Manuscript Accepted: 7 JUN 2012
- Manuscript Revised: 30 MAY 2012
- Manuscript Received: 9 MAR 2012
- Abstract
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- Cited By
Keywords:
- diabetes;
- insulin;
- monocytes;
- NADPH oxidase
Abstract
Hyperglycemia is a well-known inducing factor of oxidative stress through activation of NADPH oxidase. In addition to its plasma glucose lowering effect, insulin may also have antioxidant activity and was shown to downregulate NADPH oxidase expression in vitro. In this study, we show that a short-term (3-day) intravenous insulin infusion in patients with type 2 diabetes induces normalization of both glycemia and mRNA expression of circulating monocyte p47phox subunit.