A pilot study evaluating the efficacy of topically applied niacin derivatives for treatment of female pattern alopecia
Article first published online: 5 DEC 2005
Journal of Cosmetic Dermatology
Volume 4, Issue 4, pages 258–261, December 2005
How to Cite
Draelos, Z. D., Jacobson, E. L., Kim, H., Kim, M. and Jacobson, M. K. (2005), A pilot study evaluating the efficacy of topically applied niacin derivatives for treatment of female pattern alopecia. Journal of Cosmetic Dermatology, 4: 258–261. doi: 10.1111/j.1473-2165.2005.00201.x
- Issue published online: 5 DEC 2005
- Article first published online: 5 DEC 2005
- Accepted for publication August 4, 2005
- female pattern alopecia;
- niacin derivatives;
- topical delivery
Background Female pattern alopecia is a common dermatologic condition that manifests after puberty. The only approved drug treatment for this condition is 2% minoxidil for topical application.
Aims This pilot study examined the effect of topical application of two niacin derivatives, octyl nicotinate and tetradecyl nicotinate, on hair fullness in female alopecia.
Patients/methods Sixty female subjects with Ludwig types I–III female pattern hair loss were evaluated in a double-blinded, placebo-controlled (40 active, 20 placebo) design using standardized 35-mm photographic analyses for assessment of efficacy after 6 months of application.
Results The niacin derivatives demonstrated a statistically significant increase in hair fullness (P = 0.04 compared to the placebo).
Conclusion Whereas evaluation of hair growth in women is challenging, this 6-month pilot study demonstrated statistically significant increase in hair fullness on blinded 35-mm photographic analysis. Long-term topical application of nicotinic acid derivatives offers promise for providing benefit in female alopecia and warrants further study.