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Topical retinoids in the treatment of photoaging


A Katsambas, MD, Department of Dermatology, Andreas Sygros Skin Hospital, University of Athens, 5 Ionos Dragoumi Street, Athens 16121, Greece. E-mail:


A large number of different substances comprise the family of retinoids, which are traditionally described as vitamin A derivatives. By exerting their action through nuclear and cytoplasmic receptors they may improve photoaging. Tretinoin is the best studied retinoid in the treatment of photoaging. Others such as isotretinoin, retinaldehyde, and tazarotene, although less well studied, have given promising results.