INCI: Aqua, glycerin, dimethyl sulfone, propylene glycol, cetearyl alcohol, paraffinum liquidum, cyclopentasiloxane, squalane, caprylic/capric triglyceride, C12-15 alkyl benzoate, ethylhexyl ethylhexanoate, PEG-40 hydrogenated castor oil, stearic acid, silybum marianum, glycine soja, BISPEG/PPG-16/16 PEG/PPG-16/16 dimethicone, lecithin, tridecyl stearate, phenoxyethanol, tridecyl trimellitate, hydroxyethyl acrylate/sodium acryloyldimethyltaurate copolymer, glyceryl stearate, potassium palmitoyl hydrolized wheat protein, dipentaerythrityl hexacaprylate/hexacaprate, xanthan gum, dimethicone, disodium EDTA, polysorbate 60, propylparaben, dimethicone/vinyl dimethicone crosspolymer, ethylparaben, methylparaben, BHT
Combined effects of silymarin and methylsulfonylmethane in the management of rosacea: clinical and instrumental evaluation
Article first published online: 31 JAN 2008
© 2008 Blackwell Publishing
Journal of Cosmetic Dermatology
Volume 7, Issue 1, pages 8–14, March 2008
How to Cite
Berardesca, E., Cameli, N., Cavallotti, C., Levy, J. L., Piérard, G. E. and De Paoli Ambrosi, G. (2008), Combined effects of silymarin and methylsulfonylmethane in the management of rosacea: clinical and instrumental evaluation. Journal of Cosmetic Dermatology, 7: 8–14. doi: 10.1111/j.1473-2165.2008.00355.x
- Issue published online: 31 JAN 2008
- Article first published online: 31 JAN 2008
- Accepted for publication September 27, 2007
- acne rosacea;
Objective This study aims to evaluate a topical treatment based on silymarin/methylsulfonilmethane (S-MSM) to improve erythematous-telangiectactic rosacea.
Methods Forty-six patients affected by stage I–III rosacea entered this double-blind, placebo-controlled study. Subjects were treated for 1 month. Clinical and instrumental evaluations were done at baseline, after 10 and 20 days, and at the end of the study. Itching, stinging, erythema, and papules were investigated clinically as well as hydration and erythema instrumentally with capacitance and color measurements.
Results A statistically significant improvement was observed in many clinical and instrumental parameters investigated (P < 0.001). In particular, improvement of skin redness, papules, itching, hydration, and skin color occurred.
Conclusions The combination of silymarin and S-MSM can be useful in managing symptoms and condition of rosacea skin, especially in the rosacea subtype 1 erythemato-telangiectatic phase. The action can be considered multicentric and multiphase because of the direct modulating action on cytokines and angiokines normally involved and up-regulated in the case of such skin condition.