Hyaluronic acid plus mannitol treatment for improved skin hydration and elasticity
Version of Record online: 4 JUN 2012
© 2012 Wiley Periodicals, Inc.
Journal of Cosmetic Dermatology
Volume 11, Issue 2, pages 87–92, June 2012
How to Cite
Taieb, M., Gay, C., Sebban, S. and Secnazi, P. (2012), Hyaluronic acid plus mannitol treatment for improved skin hydration and elasticity. Journal of Cosmetic Dermatology, 11: 87–92. doi: 10.1111/j.1473-2165.2012.00608.x
- Issue online: 4 JUN 2012
- Version of Record online: 4 JUN 2012
- Accepted for publication December 17, 2011
- deep hydration;
- hyaluronic acid;
- skin hydration
Background Mesotherapy treatment of aging skin aims to replace depleting levels of minerals, vitamins, amino acids, and hyaluronic acid (HA).
Aim To investigate the efficacy of 13.5 mg/g uncross-linked HA+0.9% mannitol (HA+mannitol) on skin hydration and elasticity.
Patients/Methods Four centers enrolled 34 women: Subgroup 1 comprised 27 subjects injected using a “depot” technique; Subgroup 2 comprised seven subjects injected using a “picotage” technique.
Results A notable difference was seen between the two subgroups in outcome and subject satisfaction. In Subgroup 1, a significant improvement was seen in hydration, anisotropy, and skin roughness, but Subgroup 2 showed no significant improvements. Most physicians assessed HA+mannitol as “easy/very easy” to inject. Physician esthetic assessment in Subgroup 1 was “improved/very improved” for >90% of subjects at Day 60, and >80% according to subject assessment. 95% of subjects were delighted with treatment, and 85% would undergo repeat treatment and would recommend treatment to a friend. However, results for Subgroup 2 indicated 86% of subjects were unhappy with treatment and 83% would refuse to undergo repeat treatment.
Conclusions HA+mannitol is effective for skin hydration, anisotropy, and roughness when treated using a depot technique.