Restylane persisting in lower eyelids for 5 years


S H Dayan, MD, FACS, 845 North Michigan Avenue, Suite 923 East, Chicago, IL 60611 USA. E-mail:


The authors report the case of a 58-year-old woman presenting with “puffiness” in her lower eyelids persisting for approximately 5 years. While dark, puffy eyelid circles following hyaluronic acid placement periorbitally are not uncommon, what is so unusual in our case is that it was noted 5 years after treatment with Restylane. It has been our experience that hyaluronic acid within periorbital tissues can result in a negative cosmetic outcome that can persist for years after the treatment.