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  • Al Regaiey KA, Masternak MM, Bonkowski M, Sun L, Bartke A (2005) Long-lived growth hormone receptor knockout mice: interaction of reduced insulin-like growth factor i/insulin signaling and caloric restriction. Endocrinology 146, 851860.
  • Anisimov VN, Semenchenko AV, Yashin AI (2003) Insulin and longevity: antidiabetic biguanides as geroprotectors. Biogerontology 4, 297307.
  • Antebi A, Yeh WH, Tait D, Hedgecock EM, Riddle DL (2000) daf-12 encodes a nuclear receptor that regulates the dauer diapause and developmental age in C. elegans. Genes Dev. 14, 15121527.
  • Arantes-Oliveira N, Apfeld J, Dillin A, Kenyon C (2002) Regulation of life-span by germ-line stem cells in Caenorhabditis elegans. Science 295, 502505.
  • Ashrafi K, Chang FY, Watts JL, Fraser AG, Kamath RS, Ahringer J, Ruvkun G (2003) Genome-wide RNAi analysis of Caenorhabditis elegans fat regulatory genes. Nature 421, 268272.
  • Baker K, Marcus CB, Huffman K, Kruk H, Malfroy B, Doctrow SR (1998) Synthetic combined superoxide dismutase/catalase mimetics are protective as a delayed treatment in a rat stroke model: a key role for reactive oxygen species in ischemic brain injury. J. Pharmacol. Exp. Ther. 284, 215221.
  • Barsyte D, Lovejoy DA, Lithgow GJ (2001) Longevity and heavy metal resistance in daf-2 and age-1 long-lived mutants of Caenorhabditis elegans. FASEB J. 15, 627634.
  • Bartke A (2005) Minireview: role of the growth hormone/insulin-like growth factor system in mammalian aging. Endocrinology 146, 37183723.
  • Bauer JH, Goupil S, Garber GB, Helfand SL (2004) An accelerated assay for the identification of lifespan-extending interventions in Drosophila melanogaster. Proc. Natl Acad. Sci. USA 101, 1298012985.
  • Bluher M, Kahn BB, Kahn CR (2003) Extended longevity in mice lacking the insulin receptor in adipose tissue. Science 299, 572574.
  • Brack C, Bechter-Thuring E, Labuhn M (1997) N-acetylcysteine slows down ageing and increases the life span of Drosophila melanogaster. Cell Mol. Life Sci. 53, 960966.
  • Brenner S (1974) The genetics of Caenorhabditis elegans. Genetics 77, 7194.
  • Broughton SJ, Piper MD, Ikeya T, Bass TM, Jacobson J, Driege Y, Martinez P, Hafen E, Withers DJ, Leevers SJ, Partridge L (2005) Longer lifespan, altered metabolism, and stress resistance in Drosophila from ablation of cells making insulin-like ligands. Proc. Natl Acad. Sci. USA 102, 31053110.
  • Carroll PM, Dougherty B, Ross-Macdonald P, Browman K, FitzGerald K (2003) Model systems in drug discovery: chemical genetics meets genomics. Pharmacol. Ther. 99, 183220.
  • de Castro E, Hegi DC, Johnson TE (2004) Isolation of long-lived mutants in Caenorhabditis elegans using selection for resistance to juglone. Free Radic. Biol. Med. 37, 139145.
  • Chalfie M, Tu Y, Euskirchen G, Ward WW, Prasher DC (1994) Green fluorescent protein as a marker for gene expression. Science 263, 802805.
  • Curtis R, Geesaman BJ, Distefano PS (2005) Ageing and metabolism: drug discovery opportunities. Nat. Rev. Drug Discov. 4, 569580.
  • Cypser JR, Johnson TE (2002) Multiple stressors in Caenorhabditis elegans induce stress hormesis and extended longevity. J. Gerontol. A Biol. Sci. Med. Sci. 57, B109B114.
  • Davies AG, Pierce-Shimomura JT, Kim H, VanHoven MK, Thiele TR, Bonci A, Bargmann CI, McIntire SL (2003) A central role of the BK potassium channel in behavioral responses to ethanol in C. elegans. Cell 115, 655666.
  • Dlakic M (2002) A new family of putative insulin receptor-like proteins in C. elegans. Curr. Biol. 12, R155R157.
  • Evason K, Huang C, Yamben I, Covey DF, Kornfeld K (2005) Anticonvulsant medications extend worm life-span. Science 307, 258262.
  • Fabian TJ, Johnson TE (1994) Production of age-synchronous mass cultures of Caenorhabditis elegans. J. Gerontol. 49, B145B156.
  • Firth SM, Baxter RC (2002) Cellular actions of the insulin-like growth factor binding proteins. Endocr. Rev. 23, 824854.
  • Franceschi C, Olivieri F, Marchegiani F, Cardelli M, Cavallone L, Capri M, Salvioli S, Valensin S, De Benedictis G, Di Iorio A, Caruso C, Paolisso G, Monti D (2005) Genes involved in immune response/inflammation, IGF1/insulin pathway and response to oxidative stress play a major role in the genetics of human longevity: the lesson of centenarians. Mech. Ageing Dev. 126, 351361.
  • Gems D, Sutton AJ, Sundermeyer ML, Albert PS, King KV, Edgley ML, Larsen PL, Riddle DL (1998) Two pleiotropic classes of daf-2 mutation affect larval arrest, adult behavior, reproduction and longevity in Caenorhabditis elegans. Genetics 150, 129155.
  • Gerisch B, Weitzel C, Kober-Eisermann C, Rottiers V, Antebi A (2001) A hormonal signaling pathway influencing C. elegans metabolism, reproductive development, and life span. Dev. Cell 1, 841851.
  • Gerstbrein B, Stamatas G, Kollias N, Driscoll M (2005) In vivo spectrofluorimetry reveals endogenous biomarkers that report healthspan and dietary restriction in Caenorhabditis elegans. Aging Cell 4, 127137.
  • Giannakou ME, Goss M, Junger MA, Hafen E, Leevers SJ, Partridge L (2004) Long-lived Drosophila with overexpressed dFOXO in adult fat body. Science 305, 361.
  • Gill MS, Olsen A, Sampayo JN, Lithgow GJ (2003) An automated high-throughput assay for survival of the nematode Caenorhabditis elegans. Free Radic. Biol. Med. 35, 558565.
  • Gill MS, Held JM, Fisher AL, Gibson BW, Lithgow GJ (2004) Lipophilic regulator of a developmental switch in Caenorhabditis elegans. Aging Cell 3, 413421.
  • Gonzalez PK, Zhuang J, Doctrow SR, Malfroy B, Benson PF, Menconi MJ, Fink MP (1996) Role of oxidant stress in the adult respiratory distress syndrome: evaluation of a novel antioxidant strategy in a porcine model of endotoxin-induced acute lung injury. Shock 6, S23S26.
  • Gronemeyer H, Gustafsson JA, Laudet V (2004) Principles for modulation of the nuclear receptor superfamily. Nat. Rev. Drug Discov. 3, 950964.
  • Guarente L, Picard F (2005) Calorie restriction – the SIR2 connection. Cell 120, 473482.
  • Hadley EC, Lakatta EG, Morrison-Bogorad M, Warner HR, Hodes RJ (2005) The future of aging therapies. Cell 120, 557567.
  • Hamilton B, Dong Y, Shindo M, Liu W, Odell I, Ruvkun G, Lee SS (2005) A systematic RNAi screen for longevity genes in C. elegans. Genes Dev. 19, 15441555.
  • Hansen M, Hsu AL, Dillin A, Kenyon C (2005) New genes tied to endocrine, metabolic, and dietary regulation of lifespan from a Caenorhabditis elegans genomic RNAi screen. PLoS. Genet. 1, e17.
  • Harrington LA, Harley CB (1988) Effect of vitamin E on lifespan and reproduction in Caenorhabditis elegans. Mech. Ageing Dev. 43, 7178.
  • van Heemst D, Beekman M, Mooijaart SP, Heijmans BT, Brandt BW, Zwaan BJ, Slagboom PE, Westendorp RG (2005) Reduced insulin/IGF-1 signalling and human longevity. Aging Cell 4, 7985.
  • Henderson ST, Johnson TE (2001) daf-16 integrates developmental and environmental inputs to mediate aging in the nematode Caenorhabditiselegans. Curr. Biol. 11, 19751980.
  • Herndon LA, Schmeissner PJ, Dudaronek JM, Brown PA, Listner KM, Sakano Y, Paupard MC, Hall DH, Driscoll M (2002) Stochastic and genetic factors influence tissue-specific decline in ageing C. elegans. Nature 419, 808814.
  • Hertweck M, Baumeister R (2005) Automated assays to study longevity in C. elegans. Mech. Ageing Dev. 126, 139145.
  • Hertweck M, Hoppe T, Baumeister R (2003) C. elegans, a model for aging with high-throughput capacity. Exp. Gerontol. 38, 345346.
  • Hosokawa H, Ishii N, Ishida H, Ichimori K, Nakazawa H, Suzuki K (1994) Rapid accumulation of fluorescent material with aging in an oxygen-sensitive mutant mev-1 of Caenorhabditis elegans. Mech. Ageing Dev. 74, 161170.
  • Hosono R, Sato Y, Aizawa SI, Mitsui Y (1980) Age-dependent changes in mobility and separation of the nematode Caenorhabditis elegans. Exp. Gerontol. 15, 285289.
  • Houthoofd K, Braeckman BP, Johnson TE, Vanfleteren JR (2003) Life extension via dietary restriction is independent of the Ins/IGF-1 signalling pathway in Caenorhabditis elegans. Exp. Gerontol. 38, 947954.
  • Howitz KT, Bitterman KJ, Cohen HY, Lamming DW, Lavu S, Wood JG, Zipkin RE, Chung P, Kisielewski A, Zhang LL, Scherer B, Sinclair DA (2003) Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan. Nature 425, 191196.
  • Hsin H, Kenyon C (1999) Signals from the reproductive system regulate the lifespan of C. elegans. Nature 399, 362366.
  • Hsu AL, Murphy CT, Kenyon C (2003) Regulation of aging and age-related disease by DAF-16 and heat-shock factor. Science 300, 11421145.
  • Huang C, Xiong C, Kornfeld K (2004) Measurements of age-related changes of physiological processes that predict lifespan of Caenorhabditis elegans. Proc. Natl Acad. Sci. USA 101, 80848089.
  • Hwangbo DS, Gershman B, Tu MP, Palmer M, Tatar M (2004) Drosophila dFOXO controls lifespan and regulates insulin signalling in brain and fat body. Nature 429, 562566.
  • Ishii N, Senoo-Matsuda N, Miyake K, Yasuda K, Ishii T, Hartman PS, Furukawa S (2004) Coenzyme Q10 can prolong C. elegans lifespan by lowering oxidative stress. Mech. Ageing Dev. 125, 4146.
  • Jia K, Albert PS, Riddle DL (2002) DAF-9, a cytochrome P450 regulating C. elegans larval development and adult longevity. Development 129, 221231.
  • Kang HL, Benzer S, Min KT (2002) Life extension in Drosophila by feeding a drug. Proc. Natl Acad. Sci. USA 99, 838843.
  • Keaney M, Matthijssens F, Sharpe M, Vanfleteren J, Gems D (2004) Superoxide dismutase mimetics elevate superoxide dismutase activity in vivo but do not retard aging in the nematode Caenorhabditis elegans. Free Radic. Biol. Med. 37, 239250.
  • Kennedy S, Wang D, Ruvkun G (2004) A conserved siRNA-degrading RNase negatively regulates RNA interference in C. elegans. Nature 427, 645649.
  • Kenyon C (2005) The plasticity of aging: insights from long-lived mutants. Cell 120, 449460.
  • Klass MR (1977) Aging in the nematode Caenorhabditis elegans: major biological and environmental factors influencing life span. Mech. Ageing Dev. 6, 413429.
  • Larsen PL (1993) Aging and resistance to oxidative damage in Caenorhabditis elegans. Proc. Natl Acad. Sci. USA 90, 89058909.
  • Larsen PL, Albert PS, Riddle DL (1995) Genes that regulate both development and longevity in Caenorhabditis elegans. Genetics 139, 15671583.
  • Lee SS, Kennedy S, Tolonen AC, Ruvkun G (2003) DAF-16 target genes that control C. elegans life-span and metabolism. Science 300, 644647.
  • Li W, Kennedy SG, Ruvkun G (2003) daf-28 encodes a C. elegans insulin superfamily member that is regulated by environmental cues and acts in the DAF-2 signaling pathway. Genes Dev. 17, 844858.
  • Link CD, Cypser JR, Johnson CJ, Johnson TE (1999) Direct observation of stress response in Caenorhabditis elegans using a reporter transgene. Cell stress. Chaperones. 4, 235242.
  • Lithgow GJ (2001) Hormesis – a new hope for ageing studies or a poor second to genetics? Hum. Exp. Toxicol. 20, 301303.
  • Lithgow GJ, White TM, Melov S, Johnson TE (1995) Thermotolerance and extended life-span conferred by single-gene mutations and induced by thermal stress. Proc. Natl Acad. Sci. USA 92, 75407544.
  • Liu T, Zimmerman KK, Patterson GI (2004) Regulation of signaling genes by TGFbeta during entry into dauer diapause in C. elegans. BMC. Dev. Biol. 4, 11.
  • Malfroy B, Doctrow SR, Orr PL, Tocco G, Fedoseyeva EV, Benichou G (1997) Prevention and suppression of autoimmune encephalomyelitis by EUK-8, a synthetic catalytic scavenger of oxygen-reactive metabolites. Cell Immunol. 177, 6268.
  • Matyash V, Entchev EV, Mende F, Wilsch-Brauninger M, Thiele C, Schmidt AW, Knolker HJ, Ward S, Kurzchalia TV (2004) Sterol-derived hormone(s) controls entry into diapause in Caenorhabditis elegans by consecutive activation of DAF-12 and DAF-16. PLoS. Biol. 2, e280.
  • McElwee J, Bubb K, Thomas JH (2003) Transcriptional outputs of the Caenorhabditis elegans forkhead protein DAF-16. Aging Cell 2, 111121.
  • Melov S, Doctrow SR, Schneider JA, Haberson J, Patel M, Coskun PE, Huffman K, Wallace DC, Malfroy B (2001) Lifespan extension and rescue of spongiform encephalopathy in superoxide dismutase 2 nullizygous mice treated with superoxide dismutase-catalase mimetics. J. Neurosci. 21, 83488353.
  • Melov S, Ravenscroft J, Malik S, Gill MS, Walker DW, Clayton PE, Wallace DC, Malfroy B, Doctrow SR, Lithgow GJ (2000) Extension of life-span with superoxide dismutase/catalase mimetics. Science 289, 15671569.
  • Melov S, Wolf N, Strozyk D, Doctrow SR, Bush AI (2005) Mice transgenic for Alzheimer disease beta-amyloid develop lens cataracts that are rescued by antioxidant treatment. Free Radic. Biol. Med. 38, 258261.
  • Merris M, Wadsworth WG, Khamrai U, Bittman R, Chitwood DJ, Lenard J (2003) Sterol effects and sites of sterol accumulation in Caenorhabditis elegans: developmental requirement for 4alpha-methyl sterols. J. Lipid Res. 44, 172181.
  • Munoz MJ, Riddle DL (2003) Positive selection of Caenorhabditis elegans mutants with increased stress resistance and longevity. Genetics 163, 171180.
  • Murakami S, Johnson TE (1996) A genetic pathway conferring life extension and resistance to UV stress in Caenorhabditis elegans. Genetics 143, 12071218.
  • Murphy CT, McCarroll SA, Bargmann CI, Fraser A, Kamath RS, Ahringer J, Li H, Kenyon C (2003) Genes that act downstream of DAF-16 to influence the lifespan of Caenorhabditis elegans. Nature 424, 277283.
  • Patterson GI, Padgett RW (2000) TGFß-related pathways. Roles in Caenorhabditis elegans development. Trends Genet. 16, 2733.
  • Peng J, Stevenson FF, Doctrow SR, Andersen JK (2005) Superoxide dismutase/catalase mimetics are neuroprotective against selective paraquat-mediated dopaminergic neuron death in the substantial nigra: implications for Parkinson disease. J. Biol. Chem. 280, 2919429198.
  • Pierce SB, Costa M, Wisotzkey R, Devadhar S, Homburger SA, Buchman AR, Ferguson KC, Heller J, Platt DM, Pasquinelli AA, Liu LX, Doberstein SK, Ruvkun G (2001) Regulation of DAF-2 receptor signaling by human insulin and ins-1, a member of the unusually large and diverse C. elegans insulin gene family. Genes Dev. 15, 672686.
  • Rea SL, Wu D, Cypser JR, Vaupel JW, Johnson TE (2005) A stress-sensitive reporter predicts longevity in isogenic populations of Caenorhabditis elegans. Nat. Genet. 37, 894898.
  • Riddle DL (1988) The dauer larva. In The Nematode Caenorhabditis elegans (WoodWB, ed.). Cold Spring Harbor, NY: Cold Spring Harbor Laboratory Press, pp. 393412.
  • Riddle DL, Albert PS (1997) Genetic and environmental regulation of dauer larva development. In: C.Elegans II (RiddleDL, BlumenthalT, MeyerBJ, PriessJR, eds). Cold Spring Harbor, NY: Cold Spring Harbor Laboratory Press, pp. 739768.
  • Robertson JF (2004) Selective oestrogen receptor modulators/new antioestrogens: a clinical perspective. Cancer Treat. Rev. 30, 695706.
  • Robinson-Rechavi M, Maina CV, Gissendanner CR, Laudet V, Sluder A (2005) Explosive lineage-specific expansion of the orphan nuclear receptor HNF4 in nematodes. J. Mol. Evol. 60, 577586.
  • Rosen J, Miner JN (2005) The search for safer glucocorticoid receptor ligands. Endocr. Rev. 26, 452464.
  • Sampayo JN, Jenkins NL, Lithgow GJ (2000) Using stress resistance to isolate novel longevity mutations in Caenorhabditis elegans. Ann. N. Y. Acad. Sci. 908, 324326.
  • Sampayo JN, Olsen A, Lithgow GJ (2003) Oxidative stress in Caenorhabditis elegans: protective effects of superoxide dismutase/catalase mimetics. Aging Cell 2, 319326.
  • Shim YH, Chun JH, Lee EY, Paik YK (2002) Role of cholesterol in germ-line development of Caenorhabditis elegans. Mol. Reprod. Dev. 61, 358366.
  • Simon AF, Shih C, Mack A, Benzer S (2003) Steroid control of longevity in Drosophila melanogaster. Science 299, 14071410.
  • Sluder AE, Maina CV (2001) Nuclear receptors in nematodes: themes and variations. Trends Genet. 17, 206213.
  • Sluder AE, Mathews SW, Hough D, Yin VP, Maina CV (1999) The nuclear receptor superfamily has undergone extensive proliferation and diversification in nematodes. Genome Res. 9, 103120.
  • Szewczyk NJ, Kozak E, Conley CA (2003) Chemically defined medium and Caenorhabditis elegans. BMC. Biotechnol. 3, 19.
  • Tatar M (2004) The neuroendocrine regulation of Drosophila aging. Exp. Gerontol. 39, 17451750.
  • Tatar M, Kopelman A, Epstein D, Tu MP, Yin CM, Garofalo RS (2001) A mutant Drosophila insulin receptor homolog that extends life-span and impairs neuroendocrine function. Science 292, 107110.
  • Tatar M, Bartke A, Antebi A (2003) The endocrine regulation of aging by insulin-like signals. Science 299, 13461351.
  • Van Gilst MR, Hadjivassiliou H, Jolly A, Yamamoto KR (2005) Nuclear hormone receptor NHR-49 controls fat consumption and fatty acid composition in C. elegans. PLoS. Biol. 3, e53.
  • Vanfleteren JR (1993) Oxidative stress and ageing in Caenorhabditis elegans. Biochem. J. 292, 605608.
  • Wood WB (1988) Introduction to C. elegans biology. In The Nematode Caenorhabditis elegans (WoodWB ed.). Cold Spring Harbor, NY: Cold Spring Harbor Laboratory Press, pp. 116.
  • Wood JG, Rogina B, Lavu S, Howitz K, Helfand SL, Tatar M, Sinclair D (2004) Sirtuin activators mimic caloric restriction and delay ageing in metazoans. Nature 430, 686689.
  • Zhang JH, Chung TD, Oldenburg KR (1999) A simple statistical parameter for use in evaluation and validation of high throughput screening assays. J. Biomol. Screen. 4, 6773.