• Open Access

Long-lived dwarf mice: are bile acids a longevity signal?


David Gems, Department of Biology, University College London, Gower Street, London WC1E 6BT, UK. Tel.: 020 7679 4381; fax: 020 7679 7096; e-mail: david.gems@ucl.ac.uk


Pathways that control aging act via regulated biochemical processes, among which metabolism of xenobiotics (potentially harmful chemical agents encountered as environmental toxicants, for example, drugs, or produced internally) is one possible candidate. A new study of long-lived Ghrhr mutant mice reports that increased bile acid levels activate xenobiotic metabolism via the nuclear receptor, farnesoid X receptor. This increases resistance to xenobiotic stress, possibly contributing to longevity.