Present address: Department of Biochemistry and Biophysics, University of California, San Francisco, San Francisco, CA 94143-0448, USA.
SIRT1 transgenic mice show phenotypes resembling calorie restriction
Article first published online: 13 AUG 2007
Volume 6, Issue 6, pages 759–767, December 2007
How to Cite
Bordone, L., Cohen, D., Robinson, A., Motta, M. C., Van Veen, E., Czopik, A., Steele, A. D., Crowe, H., Marmor, S., Luo, J., Gu, W. and Guarente, L. (2007), SIRT1 transgenic mice show phenotypes resembling calorie restriction. Aging Cell, 6: 759–767. doi: 10.1111/j.1474-9726.2007.00335.x
- Issue published online: 13 AUG 2007
- Article first published online: 13 AUG 2007
- Accepted for publication 14 July 2007
Fig. S1 Genotypes of progeny of SIRT1-KI/+ ??+/+ mice are tabulated. Significant deviation from the expected 1 : 1 ratio was observed, as indicated.
Fig. S2 (A) Western blot of SIRT1 in liver and skeletal muscle in wild-type (WT) and SIRT1-KI littermates. Each lane represents an individual mouse. (B) Western blot for ?-actin, total actin and tubulin in liver, skeletal muscle and white adipose tissue (WAT) of wild-type (WT) and transgenic littermates. Sarco-actin was also blotted in muscle.
Fig. S3 Hanging, jumping and walking was measured in 8-and 10-week-old mice over a 24-h period (n = 7 per group). White bar represents wild-type (WT) mice, black bar represents SIRT1-KI mice.
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