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References

  • Arantes-Oliveira N, Apfeld J, Dillin A, Kenyon C (2002) Regulation of life-span by germ-line stem cells in Caenorhabditis elegans. Science 295, 502505.
  • Arking DE, Krebsova A, Macek M Sr, Macek M Jr, Arking A, Mian IS, Fried L, Hamosh A, Dey S, McIntosh I, Dietz HC (2002) Association of human aging with a functional variant of klotho. Proc. Natl. Acad. Sci. USA 99, 856861.
  • Arking DE, Atzmon G, Arking A, Barzilai N, Dietz HC (2005) Association between a functional variant of the KLOTHO gene and high-density lipoprotein cholesterol, blood pressure, stroke, and longevity. Circ. Res. 96, 412418.
  • Attardi LD (2005) The role of p53-mediated apoptosis as a crucial anti-tumor response to genomic instability: lessons from mouse models. Mutat. Res. 569, 145157.
  • Baldal EA, Baktawar W, Brakefield PM, Zwaan BJ (2006) Methuselah life history in a variety of conditions, implications for the use of mutants in longevity research. Exp. Gerontol. 41, 11261135.
  • Bartke A (2005) Minireview: role of the growth hormone/insulin-like growth factor system in mammalian aging. Endocrinology 146, 37183723.
  • Barzilai N, Atzmon G, Schechter C, Schaefer EJ, Cupples AL, Lipton R, Cheng S, Shuldiner AR (2003) Unique lipoprotein phenotype and genotype associated with exceptional longevity. JAMA 290, 20302040.
  • Bass TM, Weinkove D, Houthoofd K, Gems D, Partridge L (2007) Effects of resveratrol on lifespan in Drosophila melanogaster and Caenorhabditis elegans. Mech. Ageing Dev. 128, 546552.
  • Bauer JH, Helfand SL (2006) New tricks of an old molecule: lifespan regulation by p53. Aging Cell 5, 437440.
  • Baur JA, Pearson KJ, Price NL, Jamieson HA, Lerin C, Kalra A, Prabhu VV, Allard JS, Lopez-Lluch G, Lewis K, Pistell PJ, Poosala S, Becker KG, Boss O, Gwinn D, Wang M, Ramaswamy S, Fishbein KW, Spencer RG, Lakatta EG, Le CD, Shaw RJ, Navas P, Puigserver P, Ingram DK, De CR, Sinclair DA (2006) Resveratrol improves health and survival of mice on a high-calorie diet. Nature 444, 337342.
  • Bellizzi D, Rose G, Cavalcante P, Covello G, Dato S, De Rango F, Greco V, Maggiolini M, Feraco E, Mari V, Franceschi C, Passarino G, De Benedictis G (2005) A novel VNTR enhancer within the SIRT3 gene, a human homologue of SIR2, is associated with survival at oldest ages. Genomics 85, 258263.
  • Blander G, De Oliveira RM, Conboy CM, Haigis M, Guarente L (2003) Superoxide dismutase 1 knock-down induces senescence in human fibroblasts. J. Biol. Chem. 278, 3896638969.
  • Boehm M, Slack FJ (2006) MicroRNA control of lifespan and metabolism. Cell Cycle 5, 837840.
  • Bohr VA, Metter EJ, Harrigan JA, Von Kobbe C, Liu JL, Gray MD, Majumdar A, Wilson DM III, Seidman MM (2004) Werner syndrome protein 1367 variants and disposition towards coronary artery disease in Caucasian patients. Mech. Ageing Dev. 125, 491496.
  • Bonafe M, Barbieri M, Marchegiani F, Olivieri F, Ragno E, Giampieri C, Mugianesi E, Centurelli M, Franceschi C, Paolisso G (2003) Polymorphic variants of insulin-like growth factor I (IGF-I) receptor and phosphoinositide 3-kinase genes affect IGF-I plasma levels and human longevity: cues for an evolutionarily conserved mechanism of life span control. J. Clin. Endocrinol. Metab. 88, 32993304.
  • Bonafe M, Salvioli S, Barbi C, Trapassi C, Tocco F, Storci G, Invidia L, Vannini I, Rossi M, Marzi E, Mishto M, Capri M, Olivieri F, Antonicelli R., Memorandum M, Uberti D, Nacmias B, Sorbi S, Monti D, Franceschi C (2004) The different apoptotic potential of the p53 codon 72 alleles increases with age and modulates in vivo ischaemia-induced cell death. Cell Death Differ. 11, 962973.
  • Bordone L, Guarente L (2005) Calorie restriction, SIRT1 and metabolism: understanding longevity. Nat. Rev. Mol. Cell Biol. 6, 298305.
  • Britten RJ (2006) Almost all human genes resulted from ancient duplication. Proc. Natl. Acad. Sci. USA 103, 1902719032.
  • Brodsky MH, Weinert BT, Tsang G, Rong YS, McGinnis NM, Golic KG, Rio DC, Rubin GM (2004) Drosophila melanogaster MNK/Chk2 and p53 regulate multiple DNA repair and apoptotic pathways following DNA damage. Mol. Cell Biol. 24, 12191231.
  • Brown EJ, Baltimore D (2000) ATR disruption leads to chromosomal fragmentation and early embryonic lethality. Genes Dev. 14, 397402.
  • Brown-Borg HM, Borg KE, Meliska CJ, Bartke A (1996) Dwarf mice and the ageing process. Nature 384, 33.
  • Campisi J (2003) Cancer and ageing: rival demons? Nat. Rev. Cancer 3, 339349.
  • Cardon LR, Palmer LJ (2003) Population stratification and spurious allelic association. Lancet 361, 598604.
  • Carter ME, Brunet A (2007) FOXO transcription factors. Curr. Biol. 17, R113R114.
  • Casper AM, Durkin SG, Arlt MF, Glover TW (2004) Chromosomal instability at common fragile sites in Seckel syndrome. Am. J. Hum. Genet. 75, 654660.
  • Castro E, Edland SD, Lee L, Ogburn CE, Deeb SS, Brown G, Panduro A, Riestra R, Tilvis R, Louhija J, Penttinen R, Erkkola R, Wang L, Martin GM, Oshima J (2000) Polymorphisms at the Werner locus: II. 1074Leu/Phe, 1367Cys/Arg, longevity, and atherosclerosis. Am. J. Med. Genet. 95, 374380.
  • Chavous DA, Jackson FR, O’Connor CM (2001) Extension of the Drosophila lifespan by overexpression of a protein repair methyltransferase. Proc. Natl. Acad. Sci. USA 98, 1481414818.
  • Christiansen L, Petersen HC, Bathum L, Frederiksen H, McGue M, Christensen K (2004) The catalase -262C/T promoter polymorphism and aging phenotypes. J. Gerontol. A Biol. Sci. Med. Sci. 59, B886B889.
  • Clancy DJ, Gems D, Harshman LG, Oldham S, Stocker H, Hafen E, Leevers SJ, Partridge L (2001) Extension of life-span by loss of CHICO, a Drosophila insulin receptor substrate protein. Science 292, 104106.
  • Clancy DJ, Gems D, Hafen E, Leevers SJ, Partridge L (2002) Dietary restriction in long-lived dwarf flies. Science 296, 319.
  • Cleaver JE (2005) Cancer in xeroderma pigmentosum and related disorders of DNA repair. Nat. Rev. Cancer 5, 564573.
  • Conant GC, Wagner A (2004) Duplicate genes and robustness to transient gene knock-downs in Caenorhabditis elegans. Proc. Biol. Sci. 271, 8996.
  • De Benedictis G, Carotenuto L, Carrieri G, De Luca M, Falcone E, Rose G, Cavalcanti S, Corsonello F, Feraco E, Baggio G, Bertolini S, Mari D, Mattace R., Yashin AI, Bonafe M, Franceschi C (1998) Gene/Longevity association studies at four autosomal loci (REN, THO, PARP, SOD2). Eur. J. Hum. Genet. 6, 534541.
  • Derry WB, Putzke AP, Rothman JH (2001) Caenorhabditis elegans p53: role in apoptosis, meiosis, and stress resistance. Science 294, 591595.
  • Dumont P, Leu JI, Della PA III, George DL, Murphy M (2003) The codon 72 polymorphic variants of p53 have markedly different apoptotic potential. Nat. Genet. 33, 357365.
  • Eisen JA, Hanawalt PC (1999) A phylogenomic study of DNA repair genes, proteins, and processes. Mutat. Res. 435, 171213.
  • Flachsbart F, Croucher PJ, Nikolaus S, Hampe J, Cordes C, Schreiber S, Nebel A (2006) Sirtuin 1 (SIRT1) sequence variation is not associated with exceptional human longevity. Exp. Gerontol. 41, 98102.
  • Forsyth IA, Wallis M (2002) Growth hormone and prolactin – molecular and functional evolution. J. Mammary Gland Biol. Neoplasia 7, 291312.
  • Fraga MF, Esteller M (2007) Epigenetics and aging: the targets and the marks. Trends Genet. 23, 413418.
  • Fraser GE, Shavlik DJ (2001) Ten years of life: is it a matter of choice? Arch. Intern. Med. 161, 16451652.
  • Frye RA (2000) Phylogenetic classification of prokaryotic and eukaryotic Sir2-like proteins. Biochem. Biophys. Res. Commun. 273, 793798.
  • Furuyama T, Nakazawa T, Nakano I, Mori N (2000) Identification of the differential distribution patterns of mRNAs and consensus binding sequences for mouse DAF-16 homologues. Biochem. J. 349, 629634.
  • Giannakou ME, Partridge L (2007) Role of insulin-like signalling in Drosophila lifespan. Trends Biochem. Sci. 32, 180188.
  • Gu Z, Steinmetz LM, Gu X, Scharfe C, Davis RW, Li WH (2003) Role of duplicate genes in genetic robustness against null mutations. Nature 421, 6366.
  • Haigis MC, Guarente LP (2006) Mammalian sirtuins – emerging roles in physiology, aging, and calorie restriction. Genes Dev. 20, 29132921.
  • Hasty P, Campisi J, Hoeijmakers J, Van Steeg H, Vijg J (2003) Aging and genome maintenance: lessons from the mouse? Science 299, 13551359.
  • Van Heemst D, Beekman M, Mooijaart SP, Heijmans BT, Brandt BW, Zwaan BJ, Slagboom PE, Westendorp RG (2005a) Reduced insulin/IGF-1 signalling and human longevity. Aging Cell 4, 7985.
  • Van Heemst D, Mooijaart SP, Beekman M, Schreuder J, De Craen AJ, Brandt BW, Slagboom PE, Westendorp RG (2005b) Variation in the human TP53 gene affects old age survival and cancer mortality. Exp. Gerontol. 40, 1115.
  • Heijmans BT, Beekman M, Houwing-Duistermaat JJ, Cobain MR, Powell J, Van Der Blauw GJOF, Westendorp RG, Slagboom PE (2006) Lipoprotein particle profiles mark familial and sporadic human longevity. PLoS Med. 3, e495.
  • Herskind AM, McGue M, Holm NV, Sorensen TI, Harvald B, Vaupel JW (1996) The heritability of human longevity: a population-based study of 2872 Danish twin pairs born 1870–1900. Hum. Genet. 97, 319323.
  • Hjelmborg J, Iachine I, Skytthe A, Vaupel JW, McGue M, Koskenvuo M, Kaprio J, Pedersen NL, Christensen K (2006) Genetic influence on human lifespan and longevity. Hum. Genet. 119, 312321.
  • Hoeijmakers JH (2001) DNA repair mechanisms. Maturitas 38, 1722.
  • Holzenberger M, Dupont J, Ducos B, Leneuve P, Geloen A, Even PC, Cervera P, Le Bouc Y (2003) IGF-1 receptor regulates lifespan and resistance to oxidative stress in mice. Nature 421, 182187.
  • Howitz KT, Bitterman KJ, Cohen HY, Lamming DW, Lavu S, Wood JG, Zipkin RE, Chung P, Kisielewski A, Zhang LL, Scherer B, Sinclair DA (2003) Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan. Nature 425, 191196.
  • Hsin H, Kenyon C (1999) Signals from the reproductive system regulate the lifespan of C. elegans. Nature 399, 362366.
  • Hu D, Cao P, Thiels E, Chu CT, Wu GY, Oury TD, Klann E (2007) Hippocampal long-term potentiation, memory, and longevity in mice that overexpress mitochondrial superoxide dismutase. Neurobiol. Learn. Mem. 87, 372384.
  • Ibanez-Ventoso C, Yang M, Guo S, Robins H, Padgett RW, Driscoll M (2006) Modulated microRNA expression during adult lifespan in Caenorhabditis elegans. Aging Cell 5, 235246.
  • Johnson GC, Esposito L, Barratt BJ, Smith AN, Heward J, Di Genova G, Ueda H, Cordell HJ, Eaves IA, Dudbridge F, Twells RC, Payne F, Hughes W, Nutland S, Stevens H, Carr P, Tuomilehto-Wolf E, Tuomilehto J, Gough SC, Clayton DG, Todd JA (2001) Haplotype tagging for the identification of common disease genes. Nat. Genet. 29, 233237.
  • Kaeberlein M, McVey M, Guarente L (1999) The SIR2/3/4 complex and SIR2 alone promote longevity in Saccharomyces cerevisiae by two different mechanisms. Genes Dev. 13, 25702580.
  • Karim MA, Craig RL, Wang X, Hale TC, Elbein SC (2006) Analysis of FOXO1A as a candidate gene for type 2 diabetes. Mol. Genet. Metab. 88, 171177.
  • Keaney M, Gems D (2003) No increase in lifespan in Caenorhabditis elegans upon treatment with the superoxide dismutase mimetic EUK-8. Free Radic. Biol. Med. 34, 277282.
  • Kim E, Lowenson JD, Clarke S, Young SG (1999) Phenotypic analysis of seizure-prone mice lacking 1-isoaspartate (d-aspartate) O-methyltransferase. J. Biol. Chem. 274, 2067120678.
  • Kimura KD, Tissenbaum HA, Liu Y, Ruvkun G (1997) daf-2, An insulin receptor-like gene that regulates longevity and diapause in Caenorhabditis elegans. Science 277, 942946.
  • Kojima T, Kamei H, Aizu T, Arai Y, Takayama M, Nakazawa S, Ebihara Y, Inagaki H, Masui Y, Gondo Y, Sakaki Y, Hirose N (2004) Association analysis between longevity in the Japanese population and polymorphic variants of genes involved in insulin and insulin-like growth factor 1 signaling pathways. Exp. Gerontol. 39, 15951598.
  • Korpelainen H (2000) Fitness, reproduction and longevity among European aristocratic and rural Finnish families in the 1700s and 1800s. Proc. Biol. Sci. 267, 17651770.
  • Kristensen VN, Tsalenko A, Geisler J, Faldaas A, Grenaker G, Lingjaerde OC, Fjeldstad S, Yakhini Z, Lonning PE, Borresen-Dale AL (2006) Multilocus analysis of SNP and metabolic data within a given pathway. BMC Genomics 7, 5.
  • Kuningas M, Slagboom PE, Westendorp RG, Van Heemst D (2006) Impact of genetic variations in the WRN gene on age related pathologies and mortality. Mech. Ageing Dev. 127, 307313.
  • Kuningas M, Magi R, Westendorp RG, Slagboom PE, Remm M, Van Heemst D (2007a) Haplotypes in the human Foxo1a and Foxo3a genes; impact on disease and mortality at old age. Eur. J. Hum. Genet. 15, 294301.
  • Kuningas M, Putters M, Westendorp RGJ, Slagboom EP, Van Heemst D (2007b) SIRT1 gene, age-related diseases and mortality: The Leiden 85-plus study. J. Gerontol. A Biol. Sci. Medical Sci. 62, 960965.
  • Kuro-o M, Matsumura Y, Aizawa H, Kawaguchi H, Suga T, Utsugi T, Ohyama Y, Kurabayashi M, Kaname T, Kume E, Iwasaki H, Iida A, Shiraki-Iida T, Nishikawa S, Nagai R, Nabeshima YI (1997) Mutation of the mouse klotho gene leads to a syndrome resembling ageing. Nature 390, 4551.
  • Kurosu H, Yamamoto M, Clark JD, Pastor JV, Nandi A, Gurnani P, McGuinness OP, Chikuda H, Yamaguchi M, Kawaguchi H, Shimomura I, Takayama Y, Herz J, Kahn CR, Rosenblatt KP, Kuro-o M (2005) Suppression of aging in mice by the hormone Klotho. Science 309, 18291833.
  • Lakowski B, Hekimi S (1996) Determination of life-span in Caenorhabditis elegans by four clock genes. Science 272, 10101013.
  • Lambert AJ, Boysen HM, Buckingham JA, Yang T, Podlutsky A, Austad SN, Kunz TH, Buffenstein R, Brand MD (2007) Low rates of hydrogen peroxide production by isolated heart mitochondria associate with long maximum lifespan in vertebrate homeotherms. Aging Cell doi. DOI: 10.1111/j.1474-9726.2007.00312.x.
  • Laron Z (2005) Do deficiencies in growth hormone and insulin-like growth factor-1 (IGF-1) shorten or prolong longevity? Mech. Ageing Dev. 126, 305307.
  • Larsen PL (2001) Asking the age-old questions. Nat. Genet. 28, 102104.
  • Larsen PL, Albert PS, Riddle DL (1995) Genes that regulate both development and longevity in Caenorhabditis elegans. Genetics 139, 15671583.
  • Lenski RE, Ofria C, Pennock RT, Adami C (2003) The evolutionary origin of complex features. Nature 423, 139144.
  • Levine M, Tjian R (2003) Transcription regulation and animal diversity. Nature 424, 147151.
  • Li Y, Huang TT, Carlson EJ, Melov S, Ursell PC, Olson JL, Noble LJ, Yoshimura MP, Berger C, Chan PH, Wallace DC, Epstein CJ (1995) Dilated cardiomyopathy and neonatal lethality in mutant mice lacking manganese superoxide dismutase. Nat. Genet. 11, 376381.
  • Liu G, Zhou W, Park S, Wang LI, Miller DP, Wain JC, Lynch TJ, Su L, Christiani DC (2004) The SOD2 Val/Val genotype enhances the risk of nonsmall cell lung carcinoma by p53 and XRCC1 polymorphisms. Cancer 101, 28022808.
  • Long M (2001) Evolution of novel genes. Curr. Opin. Genet. Dev. 11, 673680.
  • Lowenson JD, Kim E, Young SG, Clarke S (2001) Limited accumulation of damaged proteins in 1-isoaspartyl (d-aspartyl) O-methyltransferase-deficient mice. J. Biol. Chem. 276, 2069520702.
  • Mangelsdorf DJ, Thummel C, Beato M, Herrlich P, Schutz G, Umesono K, Blumberg B, Kastner P, Mark M, Chambon P, Evans RM (1995) The nuclear receptor superfamily: the second decade. Cell 83, 835839.
  • Manolio TA, Bailey-Wilson JE, Collins FS (2006) Genes, environment and the value of prospective cohort studies. Nat. Rev. Genet. 7, 812820.
  • Marden JH, Rogina B, Montooth KL, Helfand SL (2003) Conditional tradeoffs between aging and organismal performance of Indy long-lived mutant flies. Proc. Natl. Acad. Sci. USA 100, 33693373.
  • Melov S, Schneider JA, Day BJ, Hinerfeld D, Coskun P, Mirra SS, Crapo JD, Wallace DC (1998) A novel neurological phenotype in mice lacking mitochondrial manganese superoxide dismutase. Nat. Genet. 18, 159163.
  • Melov S, Ravenscroft J, Malik S, Gill MS, Walker DW, Clayton PE, Wallace DC, Malfroy B, Doctrow SR, Lithgow GJ (2000) Extension of life-span with superoxide dismutase/catalase mimetics. Science 289, 15671569.
  • Mian IS (1998) Sequence, structural, functional, and phylogenetic analyses of three glycosidase families. Blood Cells Mol. Dis. 24, 83100.
  • Mitchell BD, Hsueh WC, King TM, Pollin TI, Sorkin J, Agarwala R, Schaffer AA, Shuldiner AR (2001) Heritability of life span in the Old Order Amish. Am. J. Med. Genet. 102, 346352.
  • Mooijaart SP, Berbee JF, Van Heemst D, Havekes LM, De Craen AJ, Slagboom PE, Rensen PC, Westendorp RG (2006) ApoE plasma levels and risk of cardiovascular mortality in old age. PLoS Med. 3, e176.
  • Mooijaart SP, Kuningas M, Westendorp RG, Houwing-Duistermaat JJ, Slagboom PE, Rensen PC, Van Heemst D (2007a) Liver X receptor alpha associates with human life span. J. Gerontol. A Biol. Sci. Med. Sci. 62, 343349.
  • Mooijaart SP, Van Vliet P, Van Heemst D, Rensen PC, Berbee JF, Jolles J, De Craen AJ, Westendorp RG (2007b) Plasma levels of apolipoprotein E and cognitive function in old age. Ann. NY Acad. Sci. 1100, 148161.
  • Morris JZ, Tissenbaum HA, Ruvkun G (1996) A phosphatidylinositol-3-OH kinase family member regulating longevity and diapause in Caenorhabditis elegans. Nature 382, 536539.
  • Mukhopadhyay A, Tissenbaum HA (2007) Reproduction and longevity: secrets revealed by C. elegans. Trends Cell Biol. 17, 6571.
  • Navarro CL, Cau P, Levy N (2006) Molecular bases of progeroid syndromes. Hum. Mol. Genet. 15, R151R161.
  • Navarro I, Leibush B, Moon TW, Plisetskaya EM, Banos N, Mendez E, Planas JV, Gutierrez J (1999) Insulin, insulin-like growth factor-I (IGF-I) and glucagon: the evolution of their receptors. Comp. Biochem. Physiol. B Biochem. Mol. Biol. 122, 137153.
  • Neel JV (1962) Diabetes mellitus: a ‘thrifty’ genotype rendered detrimental by ‘progress’? Am. J. Hum. Genet. 14, 353362.
  • Oeppen J, Vaupel JW (2002) Demography. Broken limits to life expectancy. Science 296, 10291031.
  • Ogg S, Paradis S, Gottlieb S, Patterson GI, Lee L, Tissenbaum HA, Ruvkun G (1997) The Fork head transcription factor DAF-16 transduces insulin-like metabolic and longevity signals in C. elegans. Nature 389, 994999.
  • Okamoto H, Accili D (2003) In vivo mutagenesis of the insulin receptor. J. Biol. Chem. 278, 2835928362.
  • Orr WC, Sohal RS (1994) Extension of life-span by overexpression of superoxide dismutase and catalase in Drosophila melanogaster. Science 263, 11281130.
  • Orr WC, Sohal RS (2003) Does overexpression of Cu,Zn-SOD extend life span in Drosophila melanogaster? Exp. Gerontol. 38, 227230.
  • Paolisso G, Ammendola S, Del Buono A, Gambardella A, Riondino M, Tagliamonte MR, Rizzo MR, Carella C, Varricchio M (1997) Serum levels of insulin-like growth factor-I (IGF-I) and IGF-binding protein-3 in healthy centenarians: relationship with plasma leptin and lipid concentrations, insulin action, and cognitive function. J. Clin. Endocrinol. Metab. 82, 22042209.
  • Parkes TL, Elia AJ, Dickinson D, Hilliker AJ, Phillips JP, Boulianne GL (1998) Extension of Drosophila lifespan by overexpression of human SOD1 in motorneurons. Nat. Genet. 19, 171174.
  • Partridge L, Gems D (2007) Benchmarks for ageing studies. Nature 450, 165167.
  • Partridge L, Gems D, Withers DJ (2005) Sex and death: what is the connection? Cell 120, 461472.
  • Peeters A, Barendregt JJ, Willekens F, Mackenbach JP, Al MA, Bonneux L (2003) Obesity in adulthood and its consequences for life expectancy: a life-table analysis. Ann. Intern. Med. 138, 2432.
  • Perls TT, Wilmoth J, Levenson R, Drinkwater M, Cohen M, Bogan H, Joyce E, Brewster S, Kunkel L, Puca A (2002) Life-long sustained mortality advantage of siblings of centenarians. Proc. Natl. Acad. Sci. USA 99, 84428447.
  • Pim D, Banks L (2004) p53 Polymorphic variants at codon 72 exert different effects on cell cycle progression. Int. J. Cancer 108, 196199.
  • Rose G, Dato S, Altomare K, Bellizzi D, Garasto S, Greco V, Passarino G, Feraco E, Mari V, Barbi C, Bonafe M, Franceschi C, Tan Q, Boiko S, Yashin AI, De Benedictis G (2003) Variability of the SIRT3 gene, human silent information regulator Sir2 homologue, and survivorship in the elderly. Exp. Gerontol. 38, 10651070.
  • Rottiers V, Antebi A (2006) Control of Caenorhabditis elegans life history by nuclear receptor signal transduction. Exp. Gerontol. 41, 904909.
  • Schoenmaker M, De Craen AJ, De Meijer PH, Beekman M, Blauw GJ, Slagboom PE, Westendorp RG (2006) Evidence of genetic enrichment for exceptional survival using a family approach: the Leiden longevity study. Eur. J. Hum. Genet. 14, 7984.
  • Schriner SE, Linford NJ, Martin GM, Treuting P, Ogburn CE, Emond M, Coskun PE, Ladiges W, Wolf N, Van Remmen H, Wallace DC, Rabinovitch PS (2005) Extension of murine life span by overexpression of catalase targeted to mitochondria. Science 308, 19091911.
  • Schumacher B, Hofmann K, Boulton S, Gartner A (2001) The C. elegans homolog of the p53 tumor suppressor is required for DNA damage-induced apoptosis. Curr. Biol. 11, 17221727.
  • Sgro CM, Partridge L (1999) A delayed wave of death from reproduction in Drosophila. Science 286, 25212524.
  • Sohal RS, Agarwal A, Agarwal S, Orr WC (1995) Simultaneous overexpression of copper- and zinc-containing superoxide dismutase and catalase retards age-related oxidative damage and increases metabolic potential in Drosophila melanogaster. J. Biol. Chem. 270, 1567115674.
  • Soyer OS, Bonhoeffer S (2006) Evolution of complexity in signaling pathways. Proc. Natl. Acad. Sci. USA 103, 1633716342.
  • Sullivan A, Syed N, Gasco M, Bergamaschi D, Trigiante G, Attard M, Hiller L, Farrell PJ, Smith P, Lu X, Crook T (2004) Polymorphism in wild-type p53 modulates response to chemotherapy in vitro and in vivo. Oncogene 23, 33283337.
  • Symphorien S, Woodruff RC (2003) Effect of DNA repair on aging of transgenic Drosophila melanogaster: I. mei-41 locus. J. Gerontol. A Biol. Sci. Med. Sci. 58, B782B787.
  • Taufer M, Peres A, De Andrade VM, De Oliveira G, Sa G, Do Canto ME, Dos Santos AR, Bauer ME, Da Cruz IB (2005) Is the Val16Ala manganese superoxide dismutase polymorphism associated with the aging process? J. Gerontol. A Biol. Sci. Med. Sci. 60, 432438.
  • Tyner SD, Venkatachalam S, Choi J, Jones S, Ghebranious N, Igelmann H, Lu X, Soron G, Cooper B, Brayton C, Hee PS, Thompson T, Karsenty G, Bradley A, Donehower LA (2002) p53 Mutant mice that display early ageing-associated phenotypes. Nature 415, 4553.
  • Van Remmen H, Ikeno Y, Hamilton M, Pahlavani M, Wolf N, Thorpe SR, Alderson NL, Baynes JW, Epstein CJ, Huang TT, Nelson J, Strong R, Richardson A (2003) Life-long reduction in MnSOD activity results in increased DNA damage and higher incidence of cancer but does not accelerate aging. Physiol. Genomics 16, 2937.
  • Van Vliet P, Mooijaart SP, De Craen AJ, Rensen PC, Van Heemst D, Westendorp RG (2007) Plasma levels of apolipoprotein E and risk of stroke in old age. Ann. NY Acad. Sci. 1100, 140147.
  • Walker DW, McColl G, Jenkins NL, Harris J, Lithgow GJ (2000) Evolution of lifespan in C. elegans. Nature 405, 296297.
  • Wang E (2007) MicroRNA, the putative molecular control for mid-life decline. Ageing Res. Rev. 6, 111.
  • Westendorp RG, Kirkwood TB (1998) Human longevity at the cost of reproductive success. Nature 396, 743746.
  • Wood JG, Rogina B, Lavu S, Howitz K, Helfand SL, Tatar M, Sinclair D (2004) Sirtuin activators mimic caloric restriction and delay ageing in metazoans. Nature 430, 686689.
  • Zelcer N, Tontonoz P (2006) Liver X receptors as integrators of metabolic and inflammatory signaling. J. Clin. Invest. 116, 607614.