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Epidermal stem cells are retained in vivo throughout skin aging
Article first published online: 21 JAN 2008
© 2008 The Authors
Volume 7, Issue 2, pages 250–259, April 2008
How to Cite
Giangreco, A., Qin, M., Pintar, J. E. and Watt, F. M. (2008), Epidermal stem cells are retained in vivo throughout skin aging. Aging Cell, 7: 250–259. doi: 10.1111/j.1474-9726.2008.00372.x
- Issue published online: 21 JAN 2008
- Article first published online: 21 JAN 2008
- Accepted for publication 19 December 2007
- stem cell
In healthy individuals, skin integrity is maintained by epidermal stem cells which self-renew and generate daughter cells that undergo terminal differentiation. It is currently unknown whether epidermal stem cells influence or are affected by skin aging. We therefore compared young and aged skin stem cell abundance, organization, and proliferation. We discovered that despite age-associated differences in epidermal proliferation, dermal thickness, follicle patterning, and immune cell abundance, epidermal stem cells were maintained at normal levels throughout life. These findings, coupled with observed dermal gene expression changes, suggest that epidermal stem cells themselves are intrinsically aging resistant and that local environmental or systemic factors modulate skin aging.