Maria D. Ganfornina, Sonia Do Carmo and Diego Sanchez contributed equally to this work.
Apolipoprotein D is involved in the mechanisms regulating protection from oxidative stress
Article first published online: 14 APR 2008
© 2008 The Authors. Journal compilation © Blackwell Publishing Ltd/Anatomical Society of Great Britain and Ireland 2008
Volume 7, Issue 4, pages 506–515, August 2008
How to Cite
Ganfornina, M. D., Do Carmo, S., Lora, J. M., Torres-Schumann, S., Vogel, M., Allhorn, M., González, C., Bastiani, M. J., Rassart, E. and Sanchez, D. (2008), Apolipoprotein D is involved in the mechanisms regulating protection from oxidative stress. Aging Cell, 7: 506–515. doi: 10.1111/j.1474-9726.2008.00395.x
- Issue published online: 10 JUL 2008
- Article first published online: 14 APR 2008
- Accepted for publication 29 March 2008
- lipid peroxidation;
- locomotor behavior;
- oxidative stress
Many nervous system pathologies are associated with increased levels of apolipoprotein D (ApoD), a lipocalin also expressed during normal development and aging. An ApoD homologous gene in Drosophila, Glial Lazarillo, regulates resistance to stress, and neurodegeneration in the aging brain. Here we study for the first time the protective potential of ApoD in a vertebrate model organism. Loss of mouse ApoD function increases the sensitivity to oxidative stress and the levels of brain lipid peroxidation, and impairs locomotor and learning abilities. Human ApoD overexpression in the mouse brain produces opposite effects, increasing survival and preventing the raise of brain lipid peroxides after oxidant treatment. These observations, together with its transcriptional up-regulation in the brain upon oxidative insult, identify ApoD as an acute response protein with a protective and therefore beneficial function mediated by the control of peroxidated lipids.