Randy Strong, Richard A. Miller, and David E. Harrison contributed equally to this study.
Nordihydroguaiaretic acid and aspirin increase lifespan of genetically heterogeneous male mice
Article first published online: 17 SEP 2008
© Blackwell Publishing Ltd/Anatomical Society of Great Britain and Ireland 2008. No claims to original US government works
Volume 7, Issue 5, pages 641–650, October 2008
How to Cite
Strong, R., Miller, Richard A. ., Astle, Clinton M. ., Floyd, Robert A. ., Flurkey, K., Hensley, Kenneth L. ., Javors, Martin A. ., Leeuwenburgh, C., Nelson, James F. ., Ongini, E., Nadon, Nancy L. ., Warner, Huber R. . and Harrison, David E. . (2008), Nordihydroguaiaretic acid and aspirin increase lifespan of genetically heterogeneous male mice. Aging Cell, 7: 641–650. doi: 10.1111/j.1474-9726.2008.00414.x
- Issue published online: 17 SEP 2008
- Article first published online: 17 SEP 2008
- Accepted for publication 5 June 2008
Fig. S1 Survival plots for female mice treated with nordihydroguaiaretic acid (NDGA; upper left), aspirin (upper right), nitroflurbiprofen (NFP; lower left) or 4-OH-PBN (lower right.) Each symbol represents an individual mouse dying at the age indicated. There were no significant differences between treated and control groups using the log-rank test.
Fig. S2 Effects of gender on aspirin and salicylic acid levels in plasma of young UM-HET3 mice after 4 weeks of consumption of food containing aspirin at either 20 mg per kg food (‘low dose’, right panels) or 60 mg per kg food (‘high dose’, left panels). Each symbol represents an individual mouse, and median values are shown by horizontal lines. The p-values show the outcomes of Mann–Whitney tests for differences between males and females. Top row: aspirin levels. Middle row: salicylic acid levels.
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