Viviana I. Pérez and Holly Van Remmen contributed equally to this work.
The overexpression of major antioxidant enzymes does not extend the lifespan of mice
Article first published online: 11 DEC 2008
© 2009 The Authors. Journal compilation © Blackwell Publishing Ltd/Anatomical Society of Great Britain and Ireland 2009
Volume 8, Issue 1, pages 73–75, February 2009
How to Cite
Pérez, V. I., Van Remmen, H., Bokov, A., Epstein, C. J., Vijg, J. and Richardson, A. (2009), The overexpression of major antioxidant enzymes does not extend the lifespan of mice. Aging Cell, 8: 73–75. doi: 10.1111/j.1474-9726.2008.00449.x
Re-use of this article is permitted in accordance with the Creative Commons Deed, Attribution 2.5, which does not permit commercial exploitation.
- Issue published online: 28 JAN 2009
- Article first published online: 11 DEC 2008
- Accepted for publication 25 November 2008
- antioxidant enzymes;
- transgenic and knockout mice
We evaluated the effect of overexpressing antioxidant enzymes on the lifespans of transgenic mice that overexpress copper zinc superoxide dismutase (CuZnSOD), catalase, or combinations of either CuZnSOD and catalase or CuZnSOD and manganese superoxide dismutase (MnSOD). Our results show that the overexpression of these major antioxidant enzymes, which are known to scavenge superoxide and hydrogen peroxide in the cytosolic and mitochondrial compartments, is insufficient to extend lifespan in mice.