• Open Access

The overexpression of major antioxidant enzymes does not extend the lifespan of mice

Authors

  • Viviana I. Pérez,

    1. Barshop Institute for Longevity and Aging Studies,
    2. Department of Cellular and Structural Biology,
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  • Holly Van Remmen,

    1. Barshop Institute for Longevity and Aging Studies,
    2. Department of Cellular and Structural Biology,
    3. Department of Physiology, University of Texas Health Science Center at San Antonio, San Antonio, TX 78229, USA
    4. Geriatric Research, Education, and Clinical Center, South Texas Veterans Health Care System, San Antonio, TX 78229, USA
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  • Alex Bokov,

    1. Barshop Institute for Longevity and Aging Studies,
    2. Department of Physiology, University of Texas Health Science Center at San Antonio, San Antonio, TX 78229, USA
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  • Charles J. Epstein,

    1. Institute of Human Genetics and
    2. Department of Pediatrics, School of Medicine, University of California, San Francisco, San Francisco, CA 94143, USA
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  • Jan Vijg,

    1. Department of Genetics, Albert Einstein College of Medicine, Bronx, New York, NY 10461, USA
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  • Arlan Richardson

    1. Barshop Institute for Longevity and Aging Studies,
    2. Department of Cellular and Structural Biology,
    3. Geriatric Research, Education, and Clinical Center, South Texas Veterans Health Care System, San Antonio, TX 78229, USA
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  • Viviana I. Pérez and Holly Van Remmen contributed equally to this work.

  • Re-use of this article is permitted in accordance with the Creative Commons Deed, Attribution 2.5, which does not permit commercial exploitation.


Arlan Richardson, PhD, Barshop Institute for Longevity and Aging Studies, University of Texas Health Science Center at San Antonio, Texas Research Park Campus, 15355 Lambda Drive, San Antonio, TX 78245-3207, USA. Tel.: +1 210 562 6140; fax: +1 210 562 6110; e-mail: richardsona@uthscsa.edu

Summary

We evaluated the effect of overexpressing antioxidant enzymes on the lifespans of transgenic mice that overexpress copper zinc superoxide dismutase (CuZnSOD), catalase, or combinations of either CuZnSOD and catalase or CuZnSOD and manganese superoxide dismutase (MnSOD). Our results show that the overexpression of these major antioxidant enzymes, which are known to scavenge superoxide and hydrogen peroxide in the cytosolic and mitochondrial compartments, is insufficient to extend lifespan in mice.

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