• Bahar R, Hartmann CH, Rodriguez KA, Denny AD, Busuttil RA, Dolle MET, Calder RB, Chisholm GB, Pollock BH, Klein CA, Vijg J (2006) Increased cell-to-cell variation in gene expression in ageing mouse heart. Nature 441, 10111014.
  • Bastiaens P (2009) Systems biology: when it is time to die. Nature 459, 334335.
  • Crean AJ, Marshall DJ (2009) Coping with environmental uncertainty: dynamic bet hedging as a maternal effect. Philos. Trans. R. Soc. Lond. B Biol. Sci. 364, 10871096.
  • Dobrzynski M, Bruggeman FJ (2009) Elongation dynamics shape bursty transcription and translation. Proc. Natl Acad. Sci. USA 106, 25832588.
  • Feinberg AP, Ohlsson R, Henikoff S (2006) The epigenetic progenitor origin of human cancer. Nat. Rev. Gen. 7, 2133.
  • Finch CE, Kirkwood TBL (2000) Chance, Development, and Aging. New York: Oxford University Press.
  • Fraga MF, Ballestar E, Paz MF, Ropero S, Setien F, Ballestar ML, Heine-Suner D, Cigudosa JC, Urioste M, Benitez J, Boix-Chornet M, Sanchez-Aguilera A, Ling C, Carlsson E, Poulsen P, Vaag A, Stephan Z, Spector TD, Wu YZ, Plass C, Esteller M (2005) Epigenetic differences arise during the lifetime of monozygotic twins. Proc. Natl. Acad. Sci. USA 102, 1060410609.
  • Gimelbrant A, Hutchinson JN, Thompson BR, Chess A (2007) Widespread monoallelic expression on human autosomes. Science 318, 11361140.
  • Golden TR, Beckman KB, Lee AH, Dudek N, Hubbard A, Samper E, Melov S (2007) Dramatic age-related changes in nuclear and genome copy number in the nematode Caenorhabditis elegans. Aging Cell 6, 179188.
  • Hansen GM, Markesich DC, Burnett MB, Zhu QH, Dionne KM, Richter LJ, Finnell RH, Sands AT, Zambrowicz BP, Abuin A (2008) Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Genome Res. 18, 16701679.
  • Loeb LA, Bielas JH, Beckman RA (2008) Cancers exhibit a mutator phenotype: clinical implications. Cancer Res. 68, 35513557.
  • Martin GM (2005) Epigenetic drift in aging identical twins. Proc. Natl Acad. Sci. USA 102, 1041310414.
  • Martin GM (2007a) The genetics and epigenetics of altered proliferative homeostasis in ageing and cancer. Mech. Ageing Dev. 128, 912.
  • Martin GM (2007b) Modalities of gene action predicted by the classical evolutionary biological theory of aging. Ann. NY Acad. Sci. 1100, 1420.
  • Martin GM (2009) Modalities of gene action predicted by the classical evolutionary theory of aging. In Handbook of Theoriesof Aging (BengstonDGVL, PutneyNM, SilversteinM, eds). New York: Springer, pp. 179191.
  • Nordberg M (1998) Metallothioneins: historical review and state of knowledge. Talanta 46, 243254.
  • Raj A, Peskin CS, Tranchina D, Vargas DY, Tyagi S (2006) Stochastic mRNA synthesis in mammalian cells. PLoS Biol. 4, 17071719.
  • Rea SL, Wu DQ, Cypser JR, Vaupel JW, Johnson TE (2005) A stress-sensitive reporter predicts longevity in isogenic populations of Caenorhabditis elegans. Nat. Genet. 37, 894898.
  • Rutherford SL, Lindquist S (1998) Hsp90 as a capacitor for morphological evolution. Nature 396, 336342.
  • Serra M, Aparici E, Carmona MJ (2008) When to be sexual: sex allocation theory and population density-dependent induction of sex in cyclical parthenogens. J. Plankton Res. 30, 12071214.
  • Spencer SL, Gaudet S, Albeck JG, Burke JM, Sorger PK (2009) Non-genetic origins of cell-to-cell variability in TRAIL-induced apoptosis. Nature 459, 428432.
  • Spudich JL, Koshland DE (1976) Non-genetic individuality – chance in single cell. Nature 262, 467471.
  • Vanfleteren JR, De Vreese A, Braeckman BP (1998). Two-parameter logistic and Weibull equations provide better fits to survival data from isogenic populations of Caenorhabditis elegans in axenic culture than does the Gompertz model. J. Gerontol. A Biol. Sci. Med. Sci.. 53, B393B403; discussion B404–398.
  • Vogt G, Huber M, Thiemann M, Van Den Boogaart G, Schmitz OJ, Schubart CD (2008) Production of different phenotypes from the same genotype in the same environment by developmental variation. J. Exp. Biol. 211, 510523.
  • Williams GC (1957) Pleiotropy, natural-selection, and the evolution of senescence. Evolution 11, 398411.
  • Yates FE (2008) Homeokinetics/homeodynamics: a physical heuristic for life and complexity. Ecol. Psychol. 20, 148179.