Present address: Michael S. Bonkowski, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
The growth hormone receptor gene-disrupted mouse fails to respond to an intermittent fasting diet
Version of Record online: 11 SEP 2009
© 2009 Southern Illinois University School of Medicine. Journal compilation © Blackwell Publishing Ltd/Anatomical Society of Great Britain and Ireland 2009
Volume 8, Issue 6, pages 756–760, December 2009
How to Cite
Arum, O., Bonkowski, M. S., Rocha, J. S. and Bartke, A. (2009), The growth hormone receptor gene-disrupted mouse fails to respond to an intermittent fasting diet. Aging Cell, 8: 756–760. doi: 10.1111/j.1474-9726.2009.00520.x
- Issue online: 17 NOV 2009
- Version of Record online: 11 SEP 2009
- Accepted for publication 17 August 2009
- caloric restriction;
- growth hormone;
- insulin sensitivity;
- intermittent fasting;
The interaction of longevity-conferring genes with longevity-conferring diets is poorly understood. The growth hormone receptor gene-disrupted (GHR-KO) mouse is long lived; and this longevity is not responsive to 30% caloric restriction, in contrast to wild-type animals from the same strain. To determine whether this may have been limited to a particular level of dietary restriction, we subjected GHR-KO mice to a different dietary restriction regimen, an intermittent fasting diet. The intermittent fasting diet increased the survivorship and improved insulin sensitivity of normal males, but failed to affect either parameter in GHR-KO mice. From the results of two paradigms of dietary restriction, we postulate that GHR-KO mice would be resistant to any manner of dietary restriction; potentially due to their inability to further enhance insulin sensitivity. Insulin sensitivity may be a mechanism and/or a marker of the lifespan extending potential of an intervention.