The Shc locus regulates insulin signaling and adiposity in mammals
Article first published online: 15 NOV 2010
© 2010 The Authors. Aging Cell © 2010 Blackwell Publishing Ltd/Anatomical Society of Great Britain and Ireland
Volume 10, Issue 1, pages 55–65, February 2011
How to Cite
Tomilov, A. A., Ramsey, J. J., Hagopian, K., Giorgio, M., Kim, K. M., Lam, A., Migliaccio, E., Lloyd, K. C., Berniakovich, I., Prolla, T. A., Pelicci, P. and Cortopassi, G. A. (2011), The Shc locus regulates insulin signaling and adiposity in mammals. Aging Cell, 10: 55–65. doi: 10.1111/j.1474-9726.2010.00641.x
- Issue published online: 12 JAN 2011
- Article first published online: 15 NOV 2010
- Accepted manuscript online: 8 OCT 2010 12:20PM EST
- Accepted for publication 24 September 2010
Fig. S1 Overexpression of Shc proteins decreases insulin signaling through IRS1/PI3K/Akt pathway. FL83B cells were transfected with indicated plasmids. Serum was overnight deprived from transfected cells and then media were supplemented with indicated concentrations of insulin. Ten minutes later, the cells were washed with ice-cold PBS and lysed. Cell lysates were Western analyzed with indicated antibody. Two independent transfection experiments were performed. Densitometry results of Western blots are presented in the graph, error bars are standard deviations of two experiments.
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